Abstract

Lung cancer is the leading cause of death in cancer patients, and microwave ablation (MWA) has been extensively used in clinical treatment. In this study, we characterized the spectra of MWA-treated and untreated lung squamous cell carcinoma (LSCC) tissues, as well as healthy lung tissue, and conducted a preliminary analysis of spectral variations associated with MWA treatment. The results of characteristic spectral analysis of different types of tissues indicated that MWA treatment induces an increase in the content of nucleic acids, proteins, and lipid components in lung cancer tissues. The discriminant model based on the principal component analysis - linear discriminant analysis (PCA-LDA) algorithm together with leave-one-out cross validation (LOOCV) method yield the sensitivities of 90%, 80%, and 96%, and specificities of 86.2%, 93.8%, and 100% among untreated and MWA-treated cancerous tissue, and healthy lung tissue, respectively. These results indicate that Raman spectroscopy combined with multivariate analysis techniques can be used to explore the biochemical response mechanism of cancerous tissue to MWA therapy.

© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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2019 (2)

J. Yu, Y. Guo, H. Wang, S. Su, C. Zhang, B. Man, and F. Lei, “Quasi Optical Cavity of Hierarchical ZnO Nanosheets@Ag Nanoravines with Synergy of Near- and Far-Field Effects for in Situ Raman Detection,” J. Phys. Chem. Lett. 10(13), 3676–3680 (2019).
[Crossref]

J. Li, Z. Liang, S. Wang, Z. Wang, X. Zhang, X. Hu, K. Wang, Q. He, and J. Bai, “Study on the pathological and biomedical characteristics of spinal cord injury by confocal Raman microspectral imaging,” Spectrochim. Acta, Part A 210, 148–158 (2019).
[Crossref]

2018 (7)

Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
[Crossref]

T. Bhattacharjee, L. C. Fontana, L. Raniero, and J. Ferreirastrixino, “In vivo Raman spectroscopy of breast tumors prephotodynamic and postphotodynamic therapy,” J. Raman Spectrosc. 49(5), 786–791 (2018).
[Crossref]

J. Xu, C. Li, H. Si, X. Zhao, L. Wang, S. Jiang, D. Wei, J. Yu, X. Xiu, and C. Zhang, “3D SERS substrate based on Au-Ag bi-metal nanoparticles/MoS2 hybrid with pyramid structure,” Opt. Express 26(17), 21546–21557 (2018).
[Crossref]

Y. Guo, J. Yu, C. Li, Z. Li, J. Pan, A. Liu, B. Man, T. Wu, X. Xiu, and C. Zhang, “SERS substrate based on the flexible hybrid of polydimethylsiloxane and silver colloid decorated with silver nanoparticles,” Opt. Express 26(17), 21784–21796 (2018).
[Crossref]

C. Zhang, C. Li, J. Yu, S. Jiang, S. Xu, C. Yang, Y. J. Liu, X. Gao, A. Liu, and B. Man, “SERS activated platform with three-dimensional hot spots and tunable nanometer gap,” Sens. Actuators, B 258, 163–171 (2018).
[Crossref]

H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
[Crossref]

A. Mignolet, B. R. Wood, and E. Goormaghtigh, “Intracellular investigation on the differential effects of 4 polyphenols on MCF-7 breast cancer cells by Raman imaging,” Analyst 143(1), 258–269 (2018).
[Crossref]

2017 (4)

T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
[Crossref]

A. M. Ierardi, A. Coppola, N. Lucchina, and G. Carrafiello, “Treatment of lung tumours with high-energy microwave ablation: a single-centre experience,” Med. Oncol. (N. Y., NY, U. S.) 34(1), 5 (2017).
[Crossref]

L. Zhang, “SC17.02 Lung Cancer in China: Challenges and Perspectives,” J. Thorac. Oncol. 12(1), S113–S114 (2017).
[Crossref]

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
[Crossref]

2016 (4)

W. Chen, R. Zheng, P. D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X. Q. Yu, and J. He, “Cancer statistics in China, 2015,” Ca-Cancer J. Clin. 66(2), 115–132 (2016).
[Crossref]

S. Wang, Z. Liang, Y. Gong, Y. Yin, K. Wang, Q. He, Z. Wang, and J. Bai, “Confocal raman microspectral imaging of ex vivo human spinal cord tissue,” J. Photochem. Photobiol., B 163, 177–184 (2016).
[Crossref]

C. Zappa and S. A. Mousa, “Non-small cell lung cancer: current treatment and future advances,” Transl. Lung Cancer Res. 5(3), 288–300 (2016).
[Crossref]

Y. Egashira, S. Singh, S. Bandula, and R. Illing, “Percutaneous High-Energy Microwave Ablation for the Treatment of Pulmonary Tumors: A Retrospective Single-Center Experience,” J. Vasc. Interv. Radiol. 27(4), 474–479 (2016).
[Crossref]

2015 (4)

G. Poggi, N. Tosoratti, B. Montagna, and C. Picchi, “Microwave ablation of hepatocellular carcinoma,” World Journal of Hepatology 7(25), 2578–2589 (2015).
[Crossref]

C. Zhang, S. Jiang, Y. Huo, A. H. Liu, S. Xu, X. Liu, Z. Sun, Y. Xu, Z. Li, and B. Man, “SERS detection of R6G based on a novel graphene oxide/silver nanoparticles/silicon pyramid arrays structure,” Opt. Express 23(19), 24811–24821 (2015).
[Crossref]

W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
[Crossref]

J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
[Crossref]

2014 (4)

M. Fang, J. Yuan, C. Peng, and Y. Li, “Collagen as a double-edged sword in tumor progression,” Tumor Biol. 35(4), 2871–2882 (2014).
[Crossref]

S. A. Fox, A. A. Shanblatt, H. Beckman, J. Strasswimmer, and A. C. Terentis, “Raman spectroscopy differentiates squamous cell carcinoma (SCC) from normal skin following treatment with a high-powered CO2 laser,” Lasers Surg. Med. 46(10), 757–772 (2014).
[Crossref]

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
[Crossref]

K. F. Chu and D. E. Dupuy, “Thermal ablation of tumours: biological mechanisms and advances in therapy,” Nat. Rev. Cancer 14(3), 199–208 (2014).
[Crossref]

2013 (3)

M. W. Little, D. C. Chung, P. Boardman, F. V. Gleeson, and E. M. Anderson, “Microwave Ablation of Pulmonary Malignancies Using a Novel High-energy Antenna System,” CardioVascular and Interventional Radiology 36(2), 460–465 (2013).
[Crossref]

Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
[Crossref]

G. R. Lloyd, L. E. Orr, J. Christie-Brown, K. McCarthy, S. Rose, M. Thomas, and N. Stone, “Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis,” Analyst 138(14), 3900–3908 (2013).
[Crossref]

2012 (1)

F. Bonnier and H. J. Byrne, “Understanding the molecular information contained in principal component analysis of vibrational spectra of biological systems,” Analyst 137(2), 322–332 (2012).
[Crossref]

2011 (4)

M. A. Short, S. Lam, A. M. McWilliams, D. N. Ionescu, and H. Zeng, “Using Laser Raman Spectroscopy to Reduce False Positives of Autofluorescence Bronchoscopies: A Pilot Study,” J. Thorac. Oncol. 6(7), 1206–1214 (2011).
[Crossref]

A. F. García-Flores, L. Raniero, R. A. Canevari, K. J. Jalkanen, R. A. Bitar, H. S. Martinho, and A. A. Martin, “High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer,” Theor. Chem. Acc. 130(4-6), 1231–1238 (2011).
[Crossref]

H. Abramczyk, B. Brozekpluska, J. Surmacki, J. Jablonska, and R. Kordek, “The label-free Raman imaging of human breast cancer,” J. Mol. Liq. 164(1-2), 123–131 (2011).
[Crossref]

Q. Matthews, A. Jirasek, J. Lum, and A. G. Brolo, “Biochemical signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman spectroscopy,” Phys. Med. Biol. 56(21), 6839–6855 (2011).
[Crossref]

2010 (5)

Y. Oshima, H. Shinzawa, T. Takenaka, C. Furihata, and H. Sato, “Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy,” J. Biomed. Opt. 15(1), 017009 (2010).
[Crossref]

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach,” Br. J. Surg. 97(4), 550–557 (2010).
[Crossref]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref]

L. E. Kamemoto, A. K. Misra, S. K. Sharma, M. T. Goodman, H. Luk, A. C. Dykes, and T. Acosta, “Near-Infrared Micro-Raman Spectroscopy for in Vitro Detection of Cervical Cancer,” Appl. Spectrosc. 64(3), 255–261 (2010).
[Crossref]

Q. Matthews, A. Jirasek, J. Lum, X. Duan, and A. G. Brolo, “Variability in Raman Spectra of Single Human Tumor Cells Cultured in Vitro : Correlation with Cell Cycle and Culture Confluency,” Appl. Spectrosc. 64(8), 871–887 (2010).
[Crossref]

2009 (1)

N. D. Magee, J. S. Villaumie, E. T. Marple, M. Ennis, J. S. Elborn, and J. J. Mcgarvey, “Ex vivo diagnosis of lung cancer using a Raman miniprobe,” J. Phys. Chem. B 113(23), 8137–8141 (2009).
[Crossref]

2008 (2)

M. S. Vidyasagar, K. Maheedhar, B. M. Vadhiraja, D. J. Fernendes, V. B. Kartha, and C. M. Krishna, “Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study,” Biopolymers 89(6), 530–537 (2008).
[Crossref]

M. A. Short, S. Lam, A. Mcwilliams, J. Zhao, H. Lui, and H. Zeng, “Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers,” Opt. Lett. 33(7), 711–713 (2008).
[Crossref]

2007 (2)

Z. Movasaghi, S. Rehman, and I. U. Rehman, “Raman Spectroscopy of Biological Tissues,” Appl. Spectrosc. Rev. 42(5), 493–541 (2007).
[Crossref]

J. L. Pichardomolina, C. Fraustoreyes, O. Barbosagarcia, R. Huertafranco, J. L. Gonzaleztrujillo, C. A. Ramirezalvarado, G. Gutierrezjuarez, and C. Medinagutierrez, “Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients,” Lasers Med. Sci. 22(4), 229–236 (2007).
[Crossref]

2005 (2)

A. S. Wright, L. A. Sampson, T. F. Warner, D. M. Mahvi, and F. T. Lee, “Radiofrequency versus Microwave Ablation in a Hepatic Porcine Model,” Radiology 236(1), 132–139 (2005).
[Crossref]

W. Cheng, M. Liu, H. Liu, and S. Lin, “Micro-Raman spectroscopy used to identify and grade human skin pilomatrixoma,” Microsc. Res. Tech. 68(2), 75–79 (2005).
[Crossref]

2004 (2)

N. Stone, C. Kendall, J. Smith, P. Crow, and H. Barr, “Raman spectroscopy for identification of epithelial cancers,” Faraday Discuss. 126, 141–157 (2004).
[Crossref]

S. Sigurdsson, P. A. Philipsen, L. K. Hansen, J. Larsen, M. Gniadecka, and H. C. Wulf, “Detection of skin cancer by classification of Raman spectra,” IEEE Trans. Biomed. Eng. 51(10), 1784–1793 (2004).
[Crossref]

2003 (5)

D. P. Lau, Z. Huang, H. Lui, C. S. Man, K. Berean, M. Morrison, and H. Zeng, “Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings,” Lasers Surg. Med. 32(3), 210–214 (2003).
[Crossref]

H. Yamazaki, S. Kaminaka, E. Kohda, M. Mukai, and H. O. Hamaguchi, “The diagnosis of lung cancer using 1064-nm excited near-infrared multichannel Raman spectroscopy,” Radiat. Med. 21, 1–6 (2003).

A. Molckovsky, L. M. W. K. Song, M. G. Shim, N. E. Marcon, and B. C. Wilson, “Diagnostic potential of near-infrared Raman spectroscopy in the colon: Differentiating adenomatous from hyperplastic polyps,” Gastrointestinal Endoscopy 57(3), 396–402 (2003).
[Crossref]

I. Notingher, S. Verrier, S. Haque, J. M. Polak, and L. L. Hench, “Spectroscopic study of human lung epithelial cells (A549) in culture: Living cells versus dead cells,” Biopolymers 72(4), 230–240 (2003).
[Crossref]

Z. Huang, A. H. Mcwilliams, D. I. Mclean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 41, S50 (2003).
[Crossref]

2002 (1)

R. J. Lakshmi, V. B. Kartha, C. M. Krishna, J. G. R. Solomon, G. Ullas, and P. U. Devi, “Tissue Raman Spectroscopy for the Study of Radiation Damage: Brain Irradiation of Mice,” Radiat. Res. 157(2), 175–182 (2002).
[Crossref]

Abramczyk, H.

H. Abramczyk, B. Brozekpluska, J. Surmacki, J. Jablonska, and R. Kordek, “The label-free Raman imaging of human breast cancer,” J. Mol. Liq. 164(1-2), 123–131 (2011).
[Crossref]

Acosta, T.

Anderson, E. M.

M. W. Little, D. C. Chung, P. Boardman, F. V. Gleeson, and E. M. Anderson, “Microwave Ablation of Pulmonary Malignancies Using a Novel High-energy Antenna System,” CardioVascular and Interventional Radiology 36(2), 460–465 (2013).
[Crossref]

Baade, P. D.

W. Chen, R. Zheng, P. D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X. Q. Yu, and J. He, “Cancer statistics in China, 2015,” Ca-Cancer J. Clin. 66(2), 115–132 (2016).
[Crossref]

Bai, J.

J. Li, Z. Liang, S. Wang, Z. Wang, X. Zhang, X. Hu, K. Wang, Q. He, and J. Bai, “Study on the pathological and biomedical characteristics of spinal cord injury by confocal Raman microspectral imaging,” Spectrochim. Acta, Part A 210, 148–158 (2019).
[Crossref]

S. Wang, Z. Liang, Y. Gong, Y. Yin, K. Wang, Q. He, Z. Wang, and J. Bai, “Confocal raman microspectral imaging of ex vivo human spinal cord tissue,” J. Photochem. Photobiol., B 163, 177–184 (2016).
[Crossref]

Bandula, S.

Y. Egashira, S. Singh, S. Bandula, and R. Illing, “Percutaneous High-Energy Microwave Ablation for the Treatment of Pulmonary Tumors: A Retrospective Single-Center Experience,” J. Vasc. Interv. Radiol. 27(4), 474–479 (2016).
[Crossref]

Barbosagarcia, O.

J. L. Pichardomolina, C. Fraustoreyes, O. Barbosagarcia, R. Huertafranco, J. L. Gonzaleztrujillo, C. A. Ramirezalvarado, G. Gutierrezjuarez, and C. Medinagutierrez, “Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients,” Lasers Med. Sci. 22(4), 229–236 (2007).
[Crossref]

Barr, H.

N. Stone, C. Kendall, J. Smith, P. Crow, and H. Barr, “Raman spectroscopy for identification of epithelial cancers,” Faraday Discuss. 126, 141–157 (2004).
[Crossref]

Beckman, H.

S. A. Fox, A. A. Shanblatt, H. Beckman, J. Strasswimmer, and A. C. Terentis, “Raman spectroscopy differentiates squamous cell carcinoma (SCC) from normal skin following treatment with a high-powered CO2 laser,” Lasers Surg. Med. 46(10), 757–772 (2014).
[Crossref]

Berean, K.

D. P. Lau, Z. Huang, H. Lui, C. S. Man, K. Berean, M. Morrison, and H. Zeng, “Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings,” Lasers Surg. Med. 32(3), 210–214 (2003).
[Crossref]

Berezabuziak, M.

J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
[Crossref]

Bhattacharjee, T.

T. Bhattacharjee, L. C. Fontana, L. Raniero, and J. Ferreirastrixino, “In vivo Raman spectroscopy of breast tumors prephotodynamic and postphotodynamic therapy,” J. Raman Spectrosc. 49(5), 786–791 (2018).
[Crossref]

Bialas, M.

J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
[Crossref]

Bitar, R. A.

A. F. García-Flores, L. Raniero, R. A. Canevari, K. J. Jalkanen, R. A. Bitar, H. S. Martinho, and A. A. Martin, “High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer,” Theor. Chem. Acc. 130(4-6), 1231–1238 (2011).
[Crossref]

Boardman, P.

M. W. Little, D. C. Chung, P. Boardman, F. V. Gleeson, and E. M. Anderson, “Microwave Ablation of Pulmonary Malignancies Using a Novel High-energy Antenna System,” CardioVascular and Interventional Radiology 36(2), 460–465 (2013).
[Crossref]

Bonnier, F.

F. Bonnier and H. J. Byrne, “Understanding the molecular information contained in principal component analysis of vibrational spectra of biological systems,” Analyst 137(2), 322–332 (2012).
[Crossref]

Bray, F.

W. Chen, R. Zheng, P. D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X. Q. Yu, and J. He, “Cancer statistics in China, 2015,” Ca-Cancer J. Clin. 66(2), 115–132 (2016).
[Crossref]

Brolo, A. G.

Q. Matthews, A. Jirasek, J. Lum, and A. G. Brolo, “Biochemical signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman spectroscopy,” Phys. Med. Biol. 56(21), 6839–6855 (2011).
[Crossref]

Q. Matthews, A. Jirasek, J. Lum, X. Duan, and A. G. Brolo, “Variability in Raman Spectra of Single Human Tumor Cells Cultured in Vitro : Correlation with Cell Cycle and Culture Confluency,” Appl. Spectrosc. 64(8), 871–887 (2010).
[Crossref]

Brozekpluska, B.

H. Abramczyk, B. Brozekpluska, J. Surmacki, J. Jablonska, and R. Kordek, “The label-free Raman imaging of human breast cancer,” J. Mol. Liq. 164(1-2), 123–131 (2011).
[Crossref]

Budzynski, A.

J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
[Crossref]

Byrne, H. J.

F. Bonnier and H. J. Byrne, “Understanding the molecular information contained in principal component analysis of vibrational spectra of biological systems,” Analyst 137(2), 322–332 (2012).
[Crossref]

Canevari, R. A.

A. F. García-Flores, L. Raniero, R. A. Canevari, K. J. Jalkanen, R. A. Bitar, H. S. Martinho, and A. A. Martin, “High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer,” Theor. Chem. Acc. 130(4-6), 1231–1238 (2011).
[Crossref]

Carrafiello, G.

A. M. Ierardi, A. Coppola, N. Lucchina, and G. Carrafiello, “Treatment of lung tumours with high-energy microwave ablation: a single-centre experience,” Med. Oncol. (N. Y., NY, U. S.) 34(1), 5 (2017).
[Crossref]

Chang, W. Y.

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
[Crossref]

Chen, G.

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
[Crossref]

Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
[Crossref]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref]

Chen, H. G.

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
[Crossref]

Chen, J.

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref]

Chen, M.

W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
[Crossref]

Chen, R.

W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
[Crossref]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref]

Chen, S.

D. Song, T. Chen, S. Wang, S. Chen, H. Li, F. Yu, J. Zhang, and Z. Zhang, “Study on the biochemical mechanisms of the micro-wave ablation treatment of lung cancer by ex vivo confocal Raman microspectral imaging,” Analyst (2020).

Chen, T.

D. Song, T. Chen, S. Wang, S. Chen, H. Li, F. Yu, J. Zhang, and Z. Zhang, “Study on the biochemical mechanisms of the micro-wave ablation treatment of lung cancer by ex vivo confocal Raman microspectral imaging,” Analyst (2020).

Chen, W.

W. Chen, R. Zheng, P. D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X. Q. Yu, and J. He, “Cancer statistics in China, 2015,” Ca-Cancer J. Clin. 66(2), 115–132 (2016).
[Crossref]

Cheng, M.

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref]

Cheng, W.

W. Cheng, M. Liu, H. Liu, and S. Lin, “Micro-Raman spectroscopy used to identify and grade human skin pilomatrixoma,” Microsc. Res. Tech. 68(2), 75–79 (2005).
[Crossref]

Chiang, H. K.

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
[Crossref]

Chiu, A. W.

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
[Crossref]

Christie-Brown, J.

G. R. Lloyd, L. E. Orr, J. Christie-Brown, K. McCarthy, S. Rose, M. Thomas, and N. Stone, “Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis,” Analyst 138(14), 3900–3908 (2013).
[Crossref]

Chu, K. F.

K. F. Chu and D. E. Dupuy, “Thermal ablation of tumours: biological mechanisms and advances in therapy,” Nat. Rev. Cancer 14(3), 199–208 (2014).
[Crossref]

Chu, S.

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
[Crossref]

Chung, D. C.

M. W. Little, D. C. Chung, P. Boardman, F. V. Gleeson, and E. M. Anderson, “Microwave Ablation of Pulmonary Malignancies Using a Novel High-energy Antenna System,” CardioVascular and Interventional Radiology 36(2), 460–465 (2013).
[Crossref]

Coppola, A.

A. M. Ierardi, A. Coppola, N. Lucchina, and G. Carrafiello, “Treatment of lung tumours with high-energy microwave ablation: a single-centre experience,” Med. Oncol. (N. Y., NY, U. S.) 34(1), 5 (2017).
[Crossref]

Crow, P.

N. Stone, C. Kendall, J. Smith, P. Crow, and H. Barr, “Raman spectroscopy for identification of epithelial cancers,” Faraday Discuss. 126, 141–157 (2004).
[Crossref]

Devi, P. U.

R. J. Lakshmi, V. B. Kartha, C. M. Krishna, J. G. R. Solomon, G. Ullas, and P. U. Devi, “Tissue Raman Spectroscopy for the Study of Radiation Damage: Brain Irradiation of Mice,” Radiat. Res. 157(2), 175–182 (2002).
[Crossref]

Duan, X.

Dudala, J.

J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
[Crossref]

Dupuy, D. E.

K. F. Chu and D. E. Dupuy, “Thermal ablation of tumours: biological mechanisms and advances in therapy,” Nat. Rev. Cancer 14(3), 199–208 (2014).
[Crossref]

C. J. Simon, D. E. Dupuy, and W. W. MayoSmith, “Microwave ablation: principles and applications,” 25 Suppl 1, S69 (2005).

Dykes, A. C.

Egashira, Y.

Y. Egashira, S. Singh, S. Bandula, and R. Illing, “Percutaneous High-Energy Microwave Ablation for the Treatment of Pulmonary Tumors: A Retrospective Single-Center Experience,” J. Vasc. Interv. Radiol. 27(4), 474–479 (2016).
[Crossref]

Elborn, J. S.

N. D. Magee, J. S. Villaumie, E. T. Marple, M. Ennis, J. S. Elborn, and J. J. Mcgarvey, “Ex vivo diagnosis of lung cancer using a Raman miniprobe,” J. Phys. Chem. B 113(23), 8137–8141 (2009).
[Crossref]

Ennis, M.

N. D. Magee, J. S. Villaumie, E. T. Marple, M. Ennis, J. S. Elborn, and J. J. Mcgarvey, “Ex vivo diagnosis of lung cancer using a Raman miniprobe,” J. Phys. Chem. B 113(23), 8137–8141 (2009).
[Crossref]

Erinjeri, J. P.

H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
[Crossref]

Fang, M.

M. Fang, J. Yuan, C. Peng, and Y. Li, “Collagen as a double-edged sword in tumor progression,” Tumor Biol. 35(4), 2871–2882 (2014).
[Crossref]

Feng, S.

Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
[Crossref]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref]

Fernendes, D. J.

M. S. Vidyasagar, K. Maheedhar, B. M. Vadhiraja, D. J. Fernendes, V. B. Kartha, and C. M. Krishna, “Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study,” Biopolymers 89(6), 530–537 (2008).
[Crossref]

Ferreirastrixino, J.

T. Bhattacharjee, L. C. Fontana, L. Raniero, and J. Ferreirastrixino, “In vivo Raman spectroscopy of breast tumors prephotodynamic and postphotodynamic therapy,” J. Raman Spectrosc. 49(5), 786–791 (2018).
[Crossref]

Fontana, L. C.

T. Bhattacharjee, L. C. Fontana, L. Raniero, and J. Ferreirastrixino, “In vivo Raman spectroscopy of breast tumors prephotodynamic and postphotodynamic therapy,” J. Raman Spectrosc. 49(5), 786–791 (2018).
[Crossref]

Fox, S. A.

S. A. Fox, A. A. Shanblatt, H. Beckman, J. Strasswimmer, and A. C. Terentis, “Raman spectroscopy differentiates squamous cell carcinoma (SCC) from normal skin following treatment with a high-powered CO2 laser,” Lasers Surg. Med. 46(10), 757–772 (2014).
[Crossref]

Fraustoreyes, C.

J. L. Pichardomolina, C. Fraustoreyes, O. Barbosagarcia, R. Huertafranco, J. L. Gonzaleztrujillo, C. A. Ramirezalvarado, G. Gutierrezjuarez, and C. Medinagutierrez, “Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients,” Lasers Med. Sci. 22(4), 229–236 (2007).
[Crossref]

Fu, Z.

T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
[Crossref]

Furihata, C.

Y. Oshima, H. Shinzawa, T. Takenaka, C. Furihata, and H. Sato, “Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy,” J. Biomed. Opt. 15(1), 017009 (2010).
[Crossref]

Gao, S.

H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
[Crossref]

Gao, X.

C. Zhang, C. Li, J. Yu, S. Jiang, S. Xu, C. Yang, Y. J. Liu, X. Gao, A. Liu, and B. Man, “SERS activated platform with three-dimensional hot spots and tunable nanometer gap,” Sens. Actuators, B 258, 163–171 (2018).
[Crossref]

García-Flores, A. F.

A. F. García-Flores, L. Raniero, R. A. Canevari, K. J. Jalkanen, R. A. Bitar, H. S. Martinho, and A. A. Martin, “High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer,” Theor. Chem. Acc. 130(4-6), 1231–1238 (2011).
[Crossref]

Gleeson, F. V.

M. W. Little, D. C. Chung, P. Boardman, F. V. Gleeson, and E. M. Anderson, “Microwave Ablation of Pulmonary Malignancies Using a Novel High-energy Antenna System,” CardioVascular and Interventional Radiology 36(2), 460–465 (2013).
[Crossref]

Gniadecka, M.

S. Sigurdsson, P. A. Philipsen, L. K. Hansen, J. Larsen, M. Gniadecka, and H. C. Wulf, “Detection of skin cancer by classification of Raman spectra,” IEEE Trans. Biomed. Eng. 51(10), 1784–1793 (2004).
[Crossref]

Gong, Y.

Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
[Crossref]

S. Wang, Z. Liang, Y. Gong, Y. Yin, K. Wang, Q. He, Z. Wang, and J. Bai, “Confocal raman microspectral imaging of ex vivo human spinal cord tissue,” J. Photochem. Photobiol., B 163, 177–184 (2016).
[Crossref]

Gonzaleztrujillo, J. L.

J. L. Pichardomolina, C. Fraustoreyes, O. Barbosagarcia, R. Huertafranco, J. L. Gonzaleztrujillo, C. A. Ramirezalvarado, G. Gutierrezjuarez, and C. Medinagutierrez, “Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients,” Lasers Med. Sci. 22(4), 229–236 (2007).
[Crossref]

Goodman, M. T.

Goormaghtigh, E.

A. Mignolet, B. R. Wood, and E. Goormaghtigh, “Intracellular investigation on the differential effects of 4 polyphenols on MCF-7 breast cancer cells by Raman imaging,” Analyst 143(1), 258–269 (2018).
[Crossref]

Gu, T.

T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
[Crossref]

Guo, Y.

J. Yu, Y. Guo, H. Wang, S. Su, C. Zhang, B. Man, and F. Lei, “Quasi Optical Cavity of Hierarchical ZnO Nanosheets@Ag Nanoravines with Synergy of Near- and Far-Field Effects for in Situ Raman Detection,” J. Phys. Chem. Lett. 10(13), 3676–3680 (2019).
[Crossref]

Y. Guo, J. Yu, C. Li, Z. Li, J. Pan, A. Liu, B. Man, T. Wu, X. Xiu, and C. Zhang, “SERS substrate based on the flexible hybrid of polydimethylsiloxane and silver colloid decorated with silver nanoparticles,” Opt. Express 26(17), 21784–21796 (2018).
[Crossref]

Gutierrezjuarez, G.

J. L. Pichardomolina, C. Fraustoreyes, O. Barbosagarcia, R. Huertafranco, J. L. Gonzaleztrujillo, C. A. Ramirezalvarado, G. Gutierrezjuarez, and C. Medinagutierrez, “Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients,” Lasers Med. Sci. 22(4), 229–236 (2007).
[Crossref]

Hamaguchi, H. O.

H. Yamazaki, S. Kaminaka, E. Kohda, M. Mukai, and H. O. Hamaguchi, “The diagnosis of lung cancer using 1064-nm excited near-infrared multichannel Raman spectroscopy,” Radiat. Med. 21, 1–6 (2003).

Hansen, L. K.

S. Sigurdsson, P. A. Philipsen, L. K. Hansen, J. Larsen, M. Gniadecka, and H. C. Wulf, “Detection of skin cancer by classification of Raman spectra,” IEEE Trans. Biomed. Eng. 51(10), 1784–1793 (2004).
[Crossref]

Haque, S.

I. Notingher, S. Verrier, S. Haque, J. M. Polak, and L. L. Hench, “Spectroscopic study of human lung epithelial cells (A549) in culture: Living cells versus dead cells,” Biopolymers 72(4), 230–240 (2003).
[Crossref]

He, J.

W. Chen, R. Zheng, P. D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X. Q. Yu, and J. He, “Cancer statistics in China, 2015,” Ca-Cancer J. Clin. 66(2), 115–132 (2016).
[Crossref]

He, Q.

J. Li, Z. Liang, S. Wang, Z. Wang, X. Zhang, X. Hu, K. Wang, Q. He, and J. Bai, “Study on the pathological and biomedical characteristics of spinal cord injury by confocal Raman microspectral imaging,” Spectrochim. Acta, Part A 210, 148–158 (2019).
[Crossref]

Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
[Crossref]

S. Wang, Z. Liang, Y. Gong, Y. Yin, K. Wang, Q. He, Z. Wang, and J. Bai, “Confocal raman microspectral imaging of ex vivo human spinal cord tissue,” J. Photochem. Photobiol., B 163, 177–184 (2016).
[Crossref]

Hench, L. L.

I. Notingher, S. Verrier, S. Haque, J. M. Polak, and L. L. Hench, “Spectroscopic study of human lung epithelial cells (A549) in culture: Living cells versus dead cells,” Biopolymers 72(4), 230–240 (2003).
[Crossref]

Ho, K. Y.

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach,” Br. J. Surg. 97(4), 550–557 (2010).
[Crossref]

Howk, K.

H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
[Crossref]

Hu, X.

J. Li, Z. Liang, S. Wang, Z. Wang, X. Zhang, X. Hu, K. Wang, Q. He, and J. Bai, “Study on the pathological and biomedical characteristics of spinal cord injury by confocal Raman microspectral imaging,” Spectrochim. Acta, Part A 210, 148–158 (2019).
[Crossref]

Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
[Crossref]

Hua, H.

T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
[Crossref]

Huang, E. Y.

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
[Crossref]

Huang, M.

W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
[Crossref]

Huang, S.

W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
[Crossref]

Huang, W.

W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
[Crossref]

Huang, Z.

Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
[Crossref]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref]

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach,” Br. J. Surg. 97(4), 550–557 (2010).
[Crossref]

Z. Huang, A. H. Mcwilliams, D. I. Mclean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 41, S50 (2003).
[Crossref]

D. P. Lau, Z. Huang, H. Lui, C. S. Man, K. Berean, M. Morrison, and H. Zeng, “Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings,” Lasers Surg. Med. 32(3), 210–214 (2003).
[Crossref]

Hubalewskadydejczyk, A.

J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
[Crossref]

Huertafranco, R.

J. L. Pichardomolina, C. Fraustoreyes, O. Barbosagarcia, R. Huertafranco, J. L. Gonzaleztrujillo, C. A. Ramirezalvarado, G. Gutierrezjuarez, and C. Medinagutierrez, “Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients,” Lasers Med. Sci. 22(4), 229–236 (2007).
[Crossref]

Huo, Y.

Ierardi, A. M.

A. M. Ierardi, A. Coppola, N. Lucchina, and G. Carrafiello, “Treatment of lung tumours with high-energy microwave ablation: a single-centre experience,” Med. Oncol. (N. Y., NY, U. S.) 34(1), 5 (2017).
[Crossref]

Illing, R.

Y. Egashira, S. Singh, S. Bandula, and R. Illing, “Percutaneous High-Energy Microwave Ablation for the Treatment of Pulmonary Tumors: A Retrospective Single-Center Experience,” J. Vasc. Interv. Radiol. 27(4), 474–479 (2016).
[Crossref]

Ionescu, D. N.

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
[Crossref]

M. A. Short, S. Lam, A. M. McWilliams, D. N. Ionescu, and H. Zeng, “Using Laser Raman Spectroscopy to Reduce False Positives of Autofluorescence Bronchoscopies: A Pilot Study,” J. Thorac. Oncol. 6(7), 1206–1214 (2011).
[Crossref]

Jablonska, J.

H. Abramczyk, B. Brozekpluska, J. Surmacki, J. Jablonska, and R. Kordek, “The label-free Raman imaging of human breast cancer,” J. Mol. Liq. 164(1-2), 123–131 (2011).
[Crossref]

Jalkanen, K. J.

A. F. García-Flores, L. Raniero, R. A. Canevari, K. J. Jalkanen, R. A. Bitar, H. S. Martinho, and A. A. Martin, “High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer,” Theor. Chem. Acc. 130(4-6), 1231–1238 (2011).
[Crossref]

Jemal, A.

W. Chen, R. Zheng, P. D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X. Q. Yu, and J. He, “Cancer statistics in China, 2015,” Ca-Cancer J. Clin. 66(2), 115–132 (2016).
[Crossref]

Jiang, S.

Jirasek, A.

Q. Matthews, A. Jirasek, J. Lum, and A. G. Brolo, “Biochemical signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman spectroscopy,” Phys. Med. Biol. 56(21), 6839–6855 (2011).
[Crossref]

Q. Matthews, A. Jirasek, J. Lum, X. Duan, and A. G. Brolo, “Variability in Raman Spectra of Single Human Tumor Cells Cultured in Vitro : Correlation with Cell Cycle and Culture Confluency,” Appl. Spectrosc. 64(8), 871–887 (2010).
[Crossref]

Kamemoto, L. E.

Kaminaka, S.

H. Yamazaki, S. Kaminaka, E. Kohda, M. Mukai, and H. O. Hamaguchi, “The diagnosis of lung cancer using 1064-nm excited near-infrared multichannel Raman spectroscopy,” Radiat. Med. 21, 1–6 (2003).

Kartha, V. B.

M. S. Vidyasagar, K. Maheedhar, B. M. Vadhiraja, D. J. Fernendes, V. B. Kartha, and C. M. Krishna, “Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study,” Biopolymers 89(6), 530–537 (2008).
[Crossref]

R. J. Lakshmi, V. B. Kartha, C. M. Krishna, J. G. R. Solomon, G. Ullas, and P. U. Devi, “Tissue Raman Spectroscopy for the Study of Radiation Damage: Brain Irradiation of Mice,” Radiat. Res. 157(2), 175–182 (2002).
[Crossref]

Kendall, C.

N. Stone, C. Kendall, J. Smith, P. Crow, and H. Barr, “Raman spectroscopy for identification of epithelial cancers,” Faraday Discuss. 126, 141–157 (2004).
[Crossref]

Kodama, H.

H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
[Crossref]

Kohda, E.

H. Yamazaki, S. Kaminaka, E. Kohda, M. Mukai, and H. O. Hamaguchi, “The diagnosis of lung cancer using 1064-nm excited near-infrared multichannel Raman spectroscopy,” Radiat. Med. 21, 1–6 (2003).

Kolodziej, M.

J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
[Crossref]

Kordek, R.

H. Abramczyk, B. Brozekpluska, J. Surmacki, J. Jablonska, and R. Kordek, “The label-free Raman imaging of human breast cancer,” J. Mol. Liq. 164(1-2), 123–131 (2011).
[Crossref]

Krishna, C. M.

M. S. Vidyasagar, K. Maheedhar, B. M. Vadhiraja, D. J. Fernendes, V. B. Kartha, and C. M. Krishna, “Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study,” Biopolymers 89(6), 530–537 (2008).
[Crossref]

R. J. Lakshmi, V. B. Kartha, C. M. Krishna, J. G. R. Solomon, G. Ullas, and P. U. Devi, “Tissue Raman Spectroscopy for the Study of Radiation Damage: Brain Irradiation of Mice,” Radiat. Res. 157(2), 175–182 (2002).
[Crossref]

Kuo, Y.

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
[Crossref]

Lakshmi, R. J.

R. J. Lakshmi, V. B. Kartha, C. M. Krishna, J. G. R. Solomon, G. Ullas, and P. U. Devi, “Tissue Raman Spectroscopy for the Study of Radiation Damage: Brain Irradiation of Mice,” Radiat. Res. 157(2), 175–182 (2002).
[Crossref]

Lam, S.

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
[Crossref]

M. A. Short, S. Lam, A. M. McWilliams, D. N. Ionescu, and H. Zeng, “Using Laser Raman Spectroscopy to Reduce False Positives of Autofluorescence Bronchoscopies: A Pilot Study,” J. Thorac. Oncol. 6(7), 1206–1214 (2011).
[Crossref]

M. A. Short, S. Lam, A. Mcwilliams, J. Zhao, H. Lui, and H. Zeng, “Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers,” Opt. Lett. 33(7), 711–713 (2008).
[Crossref]

Z. Huang, A. H. Mcwilliams, D. I. Mclean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 41, S50 (2003).
[Crossref]

Lankosz, M.

J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
[Crossref]

Larsen, J.

S. Sigurdsson, P. A. Philipsen, L. K. Hansen, J. Larsen, M. Gniadecka, and H. C. Wulf, “Detection of skin cancer by classification of Raman spectra,” IEEE Trans. Biomed. Eng. 51(10), 1784–1793 (2004).
[Crossref]

Lau, D. P.

D. P. Lau, Z. Huang, H. Lui, C. S. Man, K. Berean, M. Morrison, and H. Zeng, “Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings,” Lasers Surg. Med. 32(3), 210–214 (2003).
[Crossref]

Lee, F. T.

A. S. Wright, L. A. Sampson, T. F. Warner, D. M. Mahvi, and F. T. Lee, “Radiofrequency versus Microwave Ablation in a Hepatic Porcine Model,” Radiology 236(1), 132–139 (2005).
[Crossref]

Lei, F.

J. Yu, Y. Guo, H. Wang, S. Su, C. Zhang, B. Man, and F. Lei, “Quasi Optical Cavity of Hierarchical ZnO Nanosheets@Ag Nanoravines with Synergy of Near- and Far-Field Effects for in Situ Raman Detection,” J. Phys. Chem. Lett. 10(13), 3676–3680 (2019).
[Crossref]

Li, C.

Y. Guo, J. Yu, C. Li, Z. Li, J. Pan, A. Liu, B. Man, T. Wu, X. Xiu, and C. Zhang, “SERS substrate based on the flexible hybrid of polydimethylsiloxane and silver colloid decorated with silver nanoparticles,” Opt. Express 26(17), 21784–21796 (2018).
[Crossref]

C. Zhang, C. Li, J. Yu, S. Jiang, S. Xu, C. Yang, Y. J. Liu, X. Gao, A. Liu, and B. Man, “SERS activated platform with three-dimensional hot spots and tunable nanometer gap,” Sens. Actuators, B 258, 163–171 (2018).
[Crossref]

J. Xu, C. Li, H. Si, X. Zhao, L. Wang, S. Jiang, D. Wei, J. Yu, X. Xiu, and C. Zhang, “3D SERS substrate based on Au-Ag bi-metal nanoparticles/MoS2 hybrid with pyramid structure,” Opt. Express 26(17), 21546–21557 (2018).
[Crossref]

Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
[Crossref]

Li, H.

D. Song, T. Chen, S. Wang, S. Chen, H. Li, F. Yu, J. Zhang, and Z. Zhang, “Study on the biochemical mechanisms of the micro-wave ablation treatment of lung cancer by ex vivo confocal Raman microspectral imaging,” Analyst (2020).

Li, J.

J. Li, Z. Liang, S. Wang, Z. Wang, X. Zhang, X. Hu, K. Wang, Q. He, and J. Bai, “Study on the pathological and biomedical characteristics of spinal cord injury by confocal Raman microspectral imaging,” Spectrochim. Acta, Part A 210, 148–158 (2019).
[Crossref]

Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
[Crossref]

Li, Y.

W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
[Crossref]

M. Fang, J. Yuan, C. Peng, and Y. Li, “Collagen as a double-edged sword in tumor progression,” Tumor Biol. 35(4), 2871–2882 (2014).
[Crossref]

Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
[Crossref]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref]

Li, Z.

Liang, Z.

J. Li, Z. Liang, S. Wang, Z. Wang, X. Zhang, X. Hu, K. Wang, Q. He, and J. Bai, “Study on the pathological and biomedical characteristics of spinal cord injury by confocal Raman microspectral imaging,” Spectrochim. Acta, Part A 210, 148–158 (2019).
[Crossref]

Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
[Crossref]

S. Wang, Z. Liang, Y. Gong, Y. Yin, K. Wang, Q. He, Z. Wang, and J. Bai, “Confocal raman microspectral imaging of ex vivo human spinal cord tissue,” J. Photochem. Photobiol., B 163, 177–184 (2016).
[Crossref]

Lin, A. T. L.

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
[Crossref]

Lin, J.

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref]

Lin, S.

Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
[Crossref]

W. Cheng, M. Liu, H. Liu, and S. Lin, “Micro-Raman spectroscopy used to identify and grade human skin pilomatrixoma,” Microsc. Res. Tech. 68(2), 75–79 (2005).
[Crossref]

Little, M. W.

M. W. Little, D. C. Chung, P. Boardman, F. V. Gleeson, and E. M. Anderson, “Microwave Ablation of Pulmonary Malignancies Using a Novel High-energy Antenna System,” CardioVascular and Interventional Radiology 36(2), 460–465 (2013).
[Crossref]

Liu, A.

C. Zhang, C. Li, J. Yu, S. Jiang, S. Xu, C. Yang, Y. J. Liu, X. Gao, A. Liu, and B. Man, “SERS activated platform with three-dimensional hot spots and tunable nanometer gap,” Sens. Actuators, B 258, 163–171 (2018).
[Crossref]

Y. Guo, J. Yu, C. Li, Z. Li, J. Pan, A. Liu, B. Man, T. Wu, X. Xiu, and C. Zhang, “SERS substrate based on the flexible hybrid of polydimethylsiloxane and silver colloid decorated with silver nanoparticles,” Opt. Express 26(17), 21784–21796 (2018).
[Crossref]

Liu, A. H.

Liu, H.

W. Cheng, M. Liu, H. Liu, and S. Lin, “Micro-Raman spectroscopy used to identify and grade human skin pilomatrixoma,” Microsc. Res. Tech. 68(2), 75–79 (2005).
[Crossref]

Liu, L.

T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
[Crossref]

Liu, M.

W. Cheng, M. Liu, H. Liu, and S. Lin, “Micro-Raman spectroscopy used to identify and grade human skin pilomatrixoma,” Microsc. Res. Tech. 68(2), 75–79 (2005).
[Crossref]

Liu, X.

Liu, Y. J.

C. Zhang, C. Li, J. Yu, S. Jiang, S. Xu, C. Yang, Y. J. Liu, X. Gao, A. Liu, and B. Man, “SERS activated platform with three-dimensional hot spots and tunable nanometer gap,” Sens. Actuators, B 258, 163–171 (2018).
[Crossref]

Lloyd, G. R.

G. R. Lloyd, L. E. Orr, J. Christie-Brown, K. McCarthy, S. Rose, M. Thomas, and N. Stone, “Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis,” Analyst 138(14), 3900–3908 (2013).
[Crossref]

Lucchina, N.

A. M. Ierardi, A. Coppola, N. Lucchina, and G. Carrafiello, “Treatment of lung tumours with high-energy microwave ablation: a single-centre experience,” Med. Oncol. (N. Y., NY, U. S.) 34(1), 5 (2017).
[Crossref]

Lui, H.

M. A. Short, S. Lam, A. Mcwilliams, J. Zhao, H. Lui, and H. Zeng, “Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers,” Opt. Lett. 33(7), 711–713 (2008).
[Crossref]

D. P. Lau, Z. Huang, H. Lui, C. S. Man, K. Berean, M. Morrison, and H. Zeng, “Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings,” Lasers Surg. Med. 32(3), 210–214 (2003).
[Crossref]

Luk, H.

Lum, J.

Q. Matthews, A. Jirasek, J. Lum, and A. G. Brolo, “Biochemical signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman spectroscopy,” Phys. Med. Biol. 56(21), 6839–6855 (2011).
[Crossref]

Q. Matthews, A. Jirasek, J. Lum, X. Duan, and A. G. Brolo, “Variability in Raman Spectra of Single Human Tumor Cells Cultured in Vitro : Correlation with Cell Cycle and Culture Confluency,” Appl. Spectrosc. 64(8), 871–887 (2010).
[Crossref]

Magee, N. D.

N. D. Magee, J. S. Villaumie, E. T. Marple, M. Ennis, J. S. Elborn, and J. J. Mcgarvey, “Ex vivo diagnosis of lung cancer using a Raman miniprobe,” J. Phys. Chem. B 113(23), 8137–8141 (2009).
[Crossref]

Maheedhar, K.

M. S. Vidyasagar, K. Maheedhar, B. M. Vadhiraja, D. J. Fernendes, V. B. Kartha, and C. M. Krishna, “Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study,” Biopolymers 89(6), 530–537 (2008).
[Crossref]

Mahvi, D. M.

A. S. Wright, L. A. Sampson, T. F. Warner, D. M. Mahvi, and F. T. Lee, “Radiofrequency versus Microwave Ablation in a Hepatic Porcine Model,” Radiology 236(1), 132–139 (2005).
[Crossref]

Man, B.

J. Yu, Y. Guo, H. Wang, S. Su, C. Zhang, B. Man, and F. Lei, “Quasi Optical Cavity of Hierarchical ZnO Nanosheets@Ag Nanoravines with Synergy of Near- and Far-Field Effects for in Situ Raman Detection,” J. Phys. Chem. Lett. 10(13), 3676–3680 (2019).
[Crossref]

Y. Guo, J. Yu, C. Li, Z. Li, J. Pan, A. Liu, B. Man, T. Wu, X. Xiu, and C. Zhang, “SERS substrate based on the flexible hybrid of polydimethylsiloxane and silver colloid decorated with silver nanoparticles,” Opt. Express 26(17), 21784–21796 (2018).
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C. Zhang, C. Li, J. Yu, S. Jiang, S. Xu, C. Yang, Y. J. Liu, X. Gao, A. Liu, and B. Man, “SERS activated platform with three-dimensional hot spots and tunable nanometer gap,” Sens. Actuators, B 258, 163–171 (2018).
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C. Zhang, S. Jiang, Y. Huo, A. H. Liu, S. Xu, X. Liu, Z. Sun, Y. Xu, Z. Li, and B. Man, “SERS detection of R6G based on a novel graphene oxide/silver nanoparticles/silicon pyramid arrays structure,” Opt. Express 23(19), 24811–24821 (2015).
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Man, C. S.

D. P. Lau, Z. Huang, H. Lui, C. S. Man, K. Berean, M. Morrison, and H. Zeng, “Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings,” Lasers Surg. Med. 32(3), 210–214 (2003).
[Crossref]

Marcon, N. E.

A. Molckovsky, L. M. W. K. Song, M. G. Shim, N. E. Marcon, and B. C. Wilson, “Diagnostic potential of near-infrared Raman spectroscopy in the colon: Differentiating adenomatous from hyperplastic polyps,” Gastrointestinal Endoscopy 57(3), 396–402 (2003).
[Crossref]

Marple, E. T.

N. D. Magee, J. S. Villaumie, E. T. Marple, M. Ennis, J. S. Elborn, and J. J. Mcgarvey, “Ex vivo diagnosis of lung cancer using a Raman miniprobe,” J. Phys. Chem. B 113(23), 8137–8141 (2009).
[Crossref]

Martin, A. A.

A. F. García-Flores, L. Raniero, R. A. Canevari, K. J. Jalkanen, R. A. Bitar, H. S. Martinho, and A. A. Martin, “High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer,” Theor. Chem. Acc. 130(4-6), 1231–1238 (2011).
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Martinho, H. S.

A. F. García-Flores, L. Raniero, R. A. Canevari, K. J. Jalkanen, R. A. Bitar, H. S. Martinho, and A. A. Martin, “High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer,” Theor. Chem. Acc. 130(4-6), 1231–1238 (2011).
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Q. Matthews, A. Jirasek, J. Lum, and A. G. Brolo, “Biochemical signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman spectroscopy,” Phys. Med. Biol. 56(21), 6839–6855 (2011).
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Q. Matthews, A. Jirasek, J. Lum, X. Duan, and A. G. Brolo, “Variability in Raman Spectra of Single Human Tumor Cells Cultured in Vitro : Correlation with Cell Cycle and Culture Confluency,” Appl. Spectrosc. 64(8), 871–887 (2010).
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C. J. Simon, D. E. Dupuy, and W. W. MayoSmith, “Microwave ablation: principles and applications,” 25 Suppl 1, S69 (2005).

McCarthy, K.

G. R. Lloyd, L. E. Orr, J. Christie-Brown, K. McCarthy, S. Rose, M. Thomas, and N. Stone, “Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis,” Analyst 138(14), 3900–3908 (2013).
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Mcgarvey, J. J.

N. D. Magee, J. S. Villaumie, E. T. Marple, M. Ennis, J. S. Elborn, and J. J. Mcgarvey, “Ex vivo diagnosis of lung cancer using a Raman miniprobe,” J. Phys. Chem. B 113(23), 8137–8141 (2009).
[Crossref]

Mcgregor, H. C.

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
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Z. Huang, A. H. Mcwilliams, D. I. Mclean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 41, S50 (2003).
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H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
[Crossref]

M. A. Short, S. Lam, A. Mcwilliams, J. Zhao, H. Lui, and H. Zeng, “Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers,” Opt. Lett. 33(7), 711–713 (2008).
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Mcwilliams, A. H.

Z. Huang, A. H. Mcwilliams, D. I. Mclean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 41, S50 (2003).
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M. A. Short, S. Lam, A. M. McWilliams, D. N. Ionescu, and H. Zeng, “Using Laser Raman Spectroscopy to Reduce False Positives of Autofluorescence Bronchoscopies: A Pilot Study,” J. Thorac. Oncol. 6(7), 1206–1214 (2011).
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J. L. Pichardomolina, C. Fraustoreyes, O. Barbosagarcia, R. Huertafranco, J. L. Gonzaleztrujillo, C. A. Ramirezalvarado, G. Gutierrezjuarez, and C. Medinagutierrez, “Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients,” Lasers Med. Sci. 22(4), 229–236 (2007).
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A. Mignolet, B. R. Wood, and E. Goormaghtigh, “Intracellular investigation on the differential effects of 4 polyphenols on MCF-7 breast cancer cells by Raman imaging,” Analyst 143(1), 258–269 (2018).
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Molckovsky, A.

A. Molckovsky, L. M. W. K. Song, M. G. Shim, N. E. Marcon, and B. C. Wilson, “Diagnostic potential of near-infrared Raman spectroscopy in the colon: Differentiating adenomatous from hyperplastic polyps,” Gastrointestinal Endoscopy 57(3), 396–402 (2003).
[Crossref]

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H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
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G. Poggi, N. Tosoratti, B. Montagna, and C. Picchi, “Microwave ablation of hepatocellular carcinoma,” World Journal of Hepatology 7(25), 2578–2589 (2015).
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D. P. Lau, Z. Huang, H. Lui, C. S. Man, K. Berean, M. Morrison, and H. Zeng, “Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings,” Lasers Surg. Med. 32(3), 210–214 (2003).
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C. Zappa and S. A. Mousa, “Non-small cell lung cancer: current treatment and future advances,” Transl. Lung Cancer Res. 5(3), 288–300 (2016).
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Z. Movasaghi, S. Rehman, and I. U. Rehman, “Raman Spectroscopy of Biological Tissues,” Appl. Spectrosc. Rev. 42(5), 493–541 (2007).
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H. Yamazaki, S. Kaminaka, E. Kohda, M. Mukai, and H. O. Hamaguchi, “The diagnosis of lung cancer using 1064-nm excited near-infrared multichannel Raman spectroscopy,” Radiat. Med. 21, 1–6 (2003).

Notingher, I.

I. Notingher, S. Verrier, S. Haque, J. M. Polak, and L. L. Hench, “Spectroscopic study of human lung epithelial cells (A549) in culture: Living cells versus dead cells,” Biopolymers 72(4), 230–240 (2003).
[Crossref]

Orr, L. E.

G. R. Lloyd, L. E. Orr, J. Christie-Brown, K. McCarthy, S. Rose, M. Thomas, and N. Stone, “Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis,” Analyst 138(14), 3900–3908 (2013).
[Crossref]

Oshima, Y.

Y. Oshima, H. Shinzawa, T. Takenaka, C. Furihata, and H. Sato, “Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy,” J. Biomed. Opt. 15(1), 017009 (2010).
[Crossref]

Paluch, L.-R.

H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
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E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
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Pan, J.

Y. Guo, J. Yu, C. Li, Z. Li, J. Pan, A. Liu, B. Man, T. Wu, X. Xiu, and C. Zhang, “SERS substrate based on the flexible hybrid of polydimethylsiloxane and silver colloid decorated with silver nanoparticles,” Opt. Express 26(17), 21784–21796 (2018).
[Crossref]

Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
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S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
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J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
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M. Fang, J. Yuan, C. Peng, and Y. Li, “Collagen as a double-edged sword in tumor progression,” Tumor Biol. 35(4), 2871–2882 (2014).
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S. Sigurdsson, P. A. Philipsen, L. K. Hansen, J. Larsen, M. Gniadecka, and H. C. Wulf, “Detection of skin cancer by classification of Raman spectra,” IEEE Trans. Biomed. Eng. 51(10), 1784–1793 (2004).
[Crossref]

Picchi, C.

G. Poggi, N. Tosoratti, B. Montagna, and C. Picchi, “Microwave ablation of hepatocellular carcinoma,” World Journal of Hepatology 7(25), 2578–2589 (2015).
[Crossref]

Pichardomolina, J. L.

J. L. Pichardomolina, C. Fraustoreyes, O. Barbosagarcia, R. Huertafranco, J. L. Gonzaleztrujillo, C. A. Ramirezalvarado, G. Gutierrezjuarez, and C. Medinagutierrez, “Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients,” Lasers Med. Sci. 22(4), 229–236 (2007).
[Crossref]

Poggi, G.

G. Poggi, N. Tosoratti, B. Montagna, and C. Picchi, “Microwave ablation of hepatocellular carcinoma,” World Journal of Hepatology 7(25), 2578–2589 (2015).
[Crossref]

Polak, J. M.

I. Notingher, S. Verrier, S. Haque, J. M. Polak, and L. L. Hench, “Spectroscopic study of human lung epithelial cells (A549) in culture: Living cells versus dead cells,” Biopolymers 72(4), 230–240 (2003).
[Crossref]

Ramirezalvarado, C. A.

J. L. Pichardomolina, C. Fraustoreyes, O. Barbosagarcia, R. Huertafranco, J. L. Gonzaleztrujillo, C. A. Ramirezalvarado, G. Gutierrezjuarez, and C. Medinagutierrez, “Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients,” Lasers Med. Sci. 22(4), 229–236 (2007).
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T. Bhattacharjee, L. C. Fontana, L. Raniero, and J. Ferreirastrixino, “In vivo Raman spectroscopy of breast tumors prephotodynamic and postphotodynamic therapy,” J. Raman Spectrosc. 49(5), 786–791 (2018).
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A. F. García-Flores, L. Raniero, R. A. Canevari, K. J. Jalkanen, R. A. Bitar, H. S. Martinho, and A. A. Martin, “High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer,” Theor. Chem. Acc. 130(4-6), 1231–1238 (2011).
[Crossref]

Rehman, I. U.

Z. Movasaghi, S. Rehman, and I. U. Rehman, “Raman Spectroscopy of Biological Tissues,” Appl. Spectrosc. Rev. 42(5), 493–541 (2007).
[Crossref]

Rehman, S.

Z. Movasaghi, S. Rehman, and I. U. Rehman, “Raman Spectroscopy of Biological Tissues,” Appl. Spectrosc. Rev. 42(5), 493–541 (2007).
[Crossref]

Rose, S.

G. R. Lloyd, L. E. Orr, J. Christie-Brown, K. McCarthy, S. Rose, M. Thomas, and N. Stone, “Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis,” Analyst 138(14), 3900–3908 (2013).
[Crossref]

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A. S. Wright, L. A. Sampson, T. F. Warner, D. M. Mahvi, and F. T. Lee, “Radiofrequency versus Microwave Ablation in a Hepatic Porcine Model,” Radiology 236(1), 132–139 (2005).
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Y. Oshima, H. Shinzawa, T. Takenaka, C. Furihata, and H. Sato, “Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy,” J. Biomed. Opt. 15(1), 017009 (2010).
[Crossref]

Shaipanich, T.

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
[Crossref]

Shanblatt, A. A.

S. A. Fox, A. A. Shanblatt, H. Beckman, J. Strasswimmer, and A. C. Terentis, “Raman spectroscopy differentiates squamous cell carcinoma (SCC) from normal skin following treatment with a high-powered CO2 laser,” Lasers Surg. Med. 46(10), 757–772 (2014).
[Crossref]

Shao, Y.

Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
[Crossref]

Sharma, S. K.

Shim, M. G.

A. Molckovsky, L. M. W. K. Song, M. G. Shim, N. E. Marcon, and B. C. Wilson, “Diagnostic potential of near-infrared Raman spectroscopy in the colon: Differentiating adenomatous from hyperplastic polyps,” Gastrointestinal Endoscopy 57(3), 396–402 (2003).
[Crossref]

Shinzawa, H.

Y. Oshima, H. Shinzawa, T. Takenaka, C. Furihata, and H. Sato, “Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy,” J. Biomed. Opt. 15(1), 017009 (2010).
[Crossref]

Short, M. A.

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
[Crossref]

M. A. Short, S. Lam, A. M. McWilliams, D. N. Ionescu, and H. Zeng, “Using Laser Raman Spectroscopy to Reduce False Positives of Autofluorescence Bronchoscopies: A Pilot Study,” J. Thorac. Oncol. 6(7), 1206–1214 (2011).
[Crossref]

M. A. Short, S. Lam, A. Mcwilliams, J. Zhao, H. Lui, and H. Zeng, “Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers,” Opt. Lett. 33(7), 711–713 (2008).
[Crossref]

Si, H.

Sigurdsson, S.

S. Sigurdsson, P. A. Philipsen, L. K. Hansen, J. Larsen, M. Gniadecka, and H. C. Wulf, “Detection of skin cancer by classification of Raman spectra,” IEEE Trans. Biomed. Eng. 51(10), 1784–1793 (2004).
[Crossref]

Simon, C. J.

C. J. Simon, D. E. Dupuy, and W. W. MayoSmith, “Microwave ablation: principles and applications,” 25 Suppl 1, S69 (2005).

Singh, S.

Y. Egashira, S. Singh, S. Bandula, and R. Illing, “Percutaneous High-Energy Microwave Ablation for the Treatment of Pulmonary Tumors: A Retrospective Single-Center Experience,” J. Vasc. Interv. Radiol. 27(4), 474–479 (2016).
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N. Stone, C. Kendall, J. Smith, P. Crow, and H. Barr, “Raman spectroscopy for identification of epithelial cancers,” Faraday Discuss. 126, 141–157 (2004).
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Solomon, J. G. R.

R. J. Lakshmi, V. B. Kartha, C. M. Krishna, J. G. R. Solomon, G. Ullas, and P. U. Devi, “Tissue Raman Spectroscopy for the Study of Radiation Damage: Brain Irradiation of Mice,” Radiat. Res. 157(2), 175–182 (2002).
[Crossref]

Solomon, S. B.

H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
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Song, D.

D. Song, T. Chen, S. Wang, S. Chen, H. Li, F. Yu, J. Zhang, and Z. Zhang, “Study on the biochemical mechanisms of the micro-wave ablation treatment of lung cancer by ex vivo confocal Raman microspectral imaging,” Analyst (2020).

Song, J.

Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
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Song, L. M. W. K.

A. Molckovsky, L. M. W. K. Song, M. G. Shim, N. E. Marcon, and B. C. Wilson, “Diagnostic potential of near-infrared Raman spectroscopy in the colon: Differentiating adenomatous from hyperplastic polyps,” Gastrointestinal Endoscopy 57(3), 396–402 (2003).
[Crossref]

Srimathveeravalli, G.

H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
[Crossref]

Stone, N.

G. R. Lloyd, L. E. Orr, J. Christie-Brown, K. McCarthy, S. Rose, M. Thomas, and N. Stone, “Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis,” Analyst 138(14), 3900–3908 (2013).
[Crossref]

N. Stone, C. Kendall, J. Smith, P. Crow, and H. Barr, “Raman spectroscopy for identification of epithelial cancers,” Faraday Discuss. 126, 141–157 (2004).
[Crossref]

Strasswimmer, J.

S. A. Fox, A. A. Shanblatt, H. Beckman, J. Strasswimmer, and A. C. Terentis, “Raman spectroscopy differentiates squamous cell carcinoma (SCC) from normal skin following treatment with a high-powered CO2 laser,” Lasers Surg. Med. 46(10), 757–772 (2014).
[Crossref]

Su, S.

J. Yu, Y. Guo, H. Wang, S. Su, C. Zhang, B. Man, and F. Lei, “Quasi Optical Cavity of Hierarchical ZnO Nanosheets@Ag Nanoravines with Synergy of Near- and Far-Field Effects for in Situ Raman Detection,” J. Phys. Chem. Lett. 10(13), 3676–3680 (2019).
[Crossref]

Sun, L.

W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
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Sun, Z.

Surmacki, J.

H. Abramczyk, B. Brozekpluska, J. Surmacki, J. Jablonska, and R. Kordek, “The label-free Raman imaging of human breast cancer,” J. Mol. Liq. 164(1-2), 123–131 (2011).
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Surowka, A. D.

J. Dudala, M. Bialas, A. D. Surowka, M. Berezabuziak, A. Hubalewskadydejczyk, A. Budzynski, M. Pedziwiatr, M. Kolodziej, K. Wehbe, and M. Lankosz, “Biomolecular characterization of adrenal gland tumors by means of SR-FTIR,” Analyst 140(7), 2101–2106 (2015).
[Crossref]

Takenaka, T.

Y. Oshima, H. Shinzawa, T. Takenaka, C. Furihata, and H. Sato, “Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy,” J. Biomed. Opt. 15(1), 017009 (2010).
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Teh, M.

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach,” Br. J. Surg. 97(4), 550–557 (2010).
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Teh, S. K.

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach,” Br. J. Surg. 97(4), 550–557 (2010).
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Terentis, A. C.

S. A. Fox, A. A. Shanblatt, H. Beckman, J. Strasswimmer, and A. C. Terentis, “Raman spectroscopy differentiates squamous cell carcinoma (SCC) from normal skin following treatment with a high-powered CO2 laser,” Lasers Surg. Med. 46(10), 757–772 (2014).
[Crossref]

Thomas, M.

G. R. Lloyd, L. E. Orr, J. Christie-Brown, K. McCarthy, S. Rose, M. Thomas, and N. Stone, “Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis,” Analyst 138(14), 3900–3908 (2013).
[Crossref]

Tosoratti, N.

G. Poggi, N. Tosoratti, B. Montagna, and C. Picchi, “Microwave ablation of hepatocellular carcinoma,” World Journal of Hepatology 7(25), 2578–2589 (2015).
[Crossref]

Ueshima, E.

H. Kodama, E. Ueshima, S. Gao, S. Monette, L.-R. Paluch, K. Howk, J. P. Erinjeri, S. B. Solomon, and G. Srimathveeravalli, “High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects,” Int. J. Hyperthermia 34(8), 1186–1193 (2018).
[Crossref]

Ullas, G.

R. J. Lakshmi, V. B. Kartha, C. M. Krishna, J. G. R. Solomon, G. Ullas, and P. U. Devi, “Tissue Raman Spectroscopy for the Study of Radiation Damage: Brain Irradiation of Mice,” Radiat. Res. 157(2), 175–182 (2002).
[Crossref]

Vadhiraja, B. M.

M. S. Vidyasagar, K. Maheedhar, B. M. Vadhiraja, D. J. Fernendes, V. B. Kartha, and C. M. Krishna, “Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study,” Biopolymers 89(6), 530–537 (2008).
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Verrier, S.

I. Notingher, S. Verrier, S. Haque, J. M. Polak, and L. L. Hench, “Spectroscopic study of human lung epithelial cells (A549) in culture: Living cells versus dead cells,” Biopolymers 72(4), 230–240 (2003).
[Crossref]

Vidyasagar, M. S.

M. S. Vidyasagar, K. Maheedhar, B. M. Vadhiraja, D. J. Fernendes, V. B. Kartha, and C. M. Krishna, “Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study,” Biopolymers 89(6), 530–537 (2008).
[Crossref]

Villaumie, J. S.

N. D. Magee, J. S. Villaumie, E. T. Marple, M. Ennis, J. S. Elborn, and J. J. Mcgarvey, “Ex vivo diagnosis of lung cancer using a Raman miniprobe,” J. Phys. Chem. B 113(23), 8137–8141 (2009).
[Crossref]

Wang, H.

J. Yu, Y. Guo, H. Wang, S. Su, C. Zhang, B. Man, and F. Lei, “Quasi Optical Cavity of Hierarchical ZnO Nanosheets@Ag Nanoravines with Synergy of Near- and Far-Field Effects for in Situ Raman Detection,” J. Phys. Chem. Lett. 10(13), 3676–3680 (2019).
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Wang, K.

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Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
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S. Wang, Z. Liang, Y. Gong, Y. Yin, K. Wang, Q. He, Z. Wang, and J. Bai, “Confocal raman microspectral imaging of ex vivo human spinal cord tissue,” J. Photochem. Photobiol., B 163, 177–184 (2016).
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Wang, L.

Wang, S.

J. Li, Z. Liang, S. Wang, Z. Wang, X. Zhang, X. Hu, K. Wang, Q. He, and J. Bai, “Study on the pathological and biomedical characteristics of spinal cord injury by confocal Raman microspectral imaging,” Spectrochim. Acta, Part A 210, 148–158 (2019).
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Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
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S. Wang, Z. Liang, Y. Gong, Y. Yin, K. Wang, Q. He, Z. Wang, and J. Bai, “Confocal raman microspectral imaging of ex vivo human spinal cord tissue,” J. Photochem. Photobiol., B 163, 177–184 (2016).
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D. Song, T. Chen, S. Wang, S. Chen, H. Li, F. Yu, J. Zhang, and Z. Zhang, “Study on the biochemical mechanisms of the micro-wave ablation treatment of lung cancer by ex vivo confocal Raman microspectral imaging,” Analyst (2020).

Wang, W.

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
[Crossref]

Wang, Z.

J. Li, Z. Liang, S. Wang, Z. Wang, X. Zhang, X. Hu, K. Wang, Q. He, and J. Bai, “Study on the pathological and biomedical characteristics of spinal cord injury by confocal Raman microspectral imaging,” Spectrochim. Acta, Part A 210, 148–158 (2019).
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Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
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Wen, T.

T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
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A. Molckovsky, L. M. W. K. Song, M. G. Shim, N. E. Marcon, and B. C. Wilson, “Diagnostic potential of near-infrared Raman spectroscopy in the colon: Differentiating adenomatous from hyperplastic polyps,” Gastrointestinal Endoscopy 57(3), 396–402 (2003).
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A. Mignolet, B. R. Wood, and E. Goormaghtigh, “Intracellular investigation on the differential effects of 4 polyphenols on MCF-7 breast cancer cells by Raman imaging,” Analyst 143(1), 258–269 (2018).
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A. S. Wright, L. A. Sampson, T. F. Warner, D. M. Mahvi, and F. T. Lee, “Radiofrequency versus Microwave Ablation in a Hepatic Porcine Model,” Radiology 236(1), 132–139 (2005).
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W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
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Wu, T.

Wulf, H. C.

S. Sigurdsson, P. A. Philipsen, L. K. Hansen, J. Larsen, M. Gniadecka, and H. C. Wulf, “Detection of skin cancer by classification of Raman spectra,” IEEE Trans. Biomed. Eng. 51(10), 1784–1793 (2004).
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Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
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Xu, Z.

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S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach,” Br. J. Surg. 97(4), 550–557 (2010).
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S. Wang, Z. Liang, Y. Gong, Y. Yin, K. Wang, Q. He, Z. Wang, and J. Bai, “Confocal raman microspectral imaging of ex vivo human spinal cord tissue,” J. Photochem. Photobiol., B 163, 177–184 (2016).
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Yu, F.

D. Song, T. Chen, S. Wang, S. Chen, H. Li, F. Yu, J. Zhang, and Z. Zhang, “Study on the biochemical mechanisms of the micro-wave ablation treatment of lung cancer by ex vivo confocal Raman microspectral imaging,” Analyst (2020).

Yu, J.

J. Yu, Y. Guo, H. Wang, S. Su, C. Zhang, B. Man, and F. Lei, “Quasi Optical Cavity of Hierarchical ZnO Nanosheets@Ag Nanoravines with Synergy of Near- and Far-Field Effects for in Situ Raman Detection,” J. Phys. Chem. Lett. 10(13), 3676–3680 (2019).
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Y. Guo, J. Yu, C. Li, Z. Li, J. Pan, A. Liu, B. Man, T. Wu, X. Xiu, and C. Zhang, “SERS substrate based on the flexible hybrid of polydimethylsiloxane and silver colloid decorated with silver nanoparticles,” Opt. Express 26(17), 21784–21796 (2018).
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W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
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Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
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M. A. Short, S. Lam, A. M. McWilliams, D. N. Ionescu, and H. Zeng, “Using Laser Raman Spectroscopy to Reduce False Positives of Autofluorescence Bronchoscopies: A Pilot Study,” J. Thorac. Oncol. 6(7), 1206–1214 (2011).
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S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
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M. A. Short, S. Lam, A. Mcwilliams, J. Zhao, H. Lui, and H. Zeng, “Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers,” Opt. Lett. 33(7), 711–713 (2008).
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D. P. Lau, Z. Huang, H. Lui, C. S. Man, K. Berean, M. Morrison, and H. Zeng, “Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings,” Lasers Surg. Med. 32(3), 210–214 (2003).
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Z. Huang, A. H. Mcwilliams, D. I. Mclean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 41, S50 (2003).
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Zhang, C.

Zhang, D.

T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
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Zhang, J.

D. Song, T. Chen, S. Wang, S. Chen, H. Li, F. Yu, J. Zhang, and Z. Zhang, “Study on the biochemical mechanisms of the micro-wave ablation treatment of lung cancer by ex vivo confocal Raman microspectral imaging,” Analyst (2020).

Zhang, L.

L. Zhang, “SC17.02 Lung Cancer in China: Challenges and Perspectives,” J. Thorac. Oncol. 12(1), S113–S114 (2017).
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Zhang, S.

W. Chen, R. Zheng, P. D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X. Q. Yu, and J. He, “Cancer statistics in China, 2015,” Ca-Cancer J. Clin. 66(2), 115–132 (2016).
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Zhang, X.

J. Li, Z. Liang, S. Wang, Z. Wang, X. Zhang, X. Hu, K. Wang, Q. He, and J. Bai, “Study on the pathological and biomedical characteristics of spinal cord injury by confocal Raman microspectral imaging,” Spectrochim. Acta, Part A 210, 148–158 (2019).
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Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
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Zhang, Y.

T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
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T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
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Zhang, Z.

D. Song, T. Chen, S. Wang, S. Chen, H. Li, F. Yu, J. Zhang, and Z. Zhang, “Study on the biochemical mechanisms of the micro-wave ablation treatment of lung cancer by ex vivo confocal Raman microspectral imaging,” Analyst (2020).

Zhao, J.

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
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Zhao, X.

Zheng, R.

W. Chen, R. Zheng, P. D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X. Q. Yu, and J. He, “Cancer statistics in China, 2015,” Ca-Cancer J. Clin. 66(2), 115–132 (2016).
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S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach,” Br. J. Surg. 97(4), 550–557 (2010).
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Analyst (4)

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A. Mignolet, B. R. Wood, and E. Goormaghtigh, “Intracellular investigation on the differential effects of 4 polyphenols on MCF-7 breast cancer cells by Raman imaging,” Analyst 143(1), 258–269 (2018).
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Appl. Spectrosc. (2)

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BioMed Res. Int. (1)

T. Gu, T. Wen, Y. Zhang, D. Zhang, H. Hua, L. Liu, Y. Zhang, Z. Fu, and Z. Yuan, “Impact of Elevated Circulating Histones on Systemic Inflammation after Radiofrequency Ablation in Lung Cancer Patients,” BioMed Res. Int. 2017, 1–6 (2017).
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M. S. Vidyasagar, K. Maheedhar, B. M. Vadhiraja, D. J. Fernendes, V. B. Kartha, and C. M. Krishna, “Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study,” Biopolymers 89(6), 530–537 (2008).
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S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
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Br. J. Surg. (1)

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach,” Br. J. Surg. 97(4), 550–557 (2010).
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Ca-Cancer J. Clin. (1)

W. Chen, R. Zheng, P. D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X. Q. Yu, and J. He, “Cancer statistics in China, 2015,” Ca-Cancer J. Clin. 66(2), 115–132 (2016).
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M. W. Little, D. C. Chung, P. Boardman, F. V. Gleeson, and E. M. Anderson, “Microwave Ablation of Pulmonary Malignancies Using a Novel High-energy Antenna System,” CardioVascular and Interventional Radiology 36(2), 460–465 (2013).
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Cell. Physiol. Biochem. (1)

Y. Gong, S. Wang, Z. Liang, Z. Wang, X. Zhang, J. Li, J. Song, X. Hu, K. Wang, and Q. He, “Label-Free Spectral Imaging Unveils Biochemical Mechanisms of Low-Level Laser Therapy on Spinal Cord Injury,” Cell. Physiol. Biochem. 49(3), 1127–1142 (2018).
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Faraday Discuss. (1)

N. Stone, C. Kendall, J. Smith, P. Crow, and H. Barr, “Raman spectroscopy for identification of epithelial cancers,” Faraday Discuss. 126, 141–157 (2004).
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Gastrointestinal Endoscopy (1)

A. Molckovsky, L. M. W. K. Song, M. G. Shim, N. E. Marcon, and B. C. Wilson, “Diagnostic potential of near-infrared Raman spectroscopy in the colon: Differentiating adenomatous from hyperplastic polyps,” Gastrointestinal Endoscopy 57(3), 396–402 (2003).
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IEEE Trans. Biomed. Eng. (1)

S. Sigurdsson, P. A. Philipsen, L. K. Hansen, J. Larsen, M. Gniadecka, and H. C. Wulf, “Detection of skin cancer by classification of Raman spectra,” IEEE Trans. Biomed. Eng. 51(10), 1784–1793 (2004).
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Int. J. Cancer (1)

Z. Huang, A. H. Mcwilliams, D. I. Mclean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 41, S50 (2003).
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J. Biomed. Opt. (2)

Y. Oshima, H. Shinzawa, T. Takenaka, C. Furihata, and H. Sato, “Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy,” J. Biomed. Opt. 15(1), 017009 (2010).
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Y. Li, J. Pan, G. Chen, C. Li, S. Lin, Y. Shao, S. Feng, Z. Huang, S. Xie, and H. Zeng, “Micro-Raman spectroscopy study of cancerous and normal nasopharyngeal tissues,” J. Biomed. Opt. 18(2), 027003 (2013).
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J. Biophotonics (1)

H. C. Mcgregor, M. A. Short, A. Mcwilliams, T. Shaipanich, D. N. Ionescu, J. Zhao, W. Wang, G. Chen, S. Lam, and H. Zeng, “Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection,” J. Biophotonics 10(1), 98–110 (2017).
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J. Mol. Liq. (1)

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J. Photochem. Photobiol., B (1)

S. Wang, Z. Liang, Y. Gong, Y. Yin, K. Wang, Q. He, Z. Wang, and J. Bai, “Confocal raman microspectral imaging of ex vivo human spinal cord tissue,” J. Photochem. Photobiol., B 163, 177–184 (2016).
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J. Phys. Chem. B (1)

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J. Phys. Chem. Lett. (1)

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J. Raman Spectrosc. (3)

E. Y. Huang, S. Chu, H. G. Chen, W. Y. Chang, Y. Kuo, C. Pan, A. W. Chiu, A. T. L. Lin, and H. K. Chiang, “Raman spectral analysis of renal tissue: a novel application,” J. Raman Spectrosc. 45(9), 788–793 (2014).
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T. Bhattacharjee, L. C. Fontana, L. Raniero, and J. Ferreirastrixino, “In vivo Raman spectroscopy of breast tumors prephotodynamic and postphotodynamic therapy,” J. Raman Spectrosc. 49(5), 786–791 (2018).
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W. Huang, S. Wu, M. Chen, L. Sun, Y. Li, M. Huang, S. Huang, Z. Xu, R. Chen, and H. Zeng, “Study of both fingerprint and high wavenumber Raman spectroscopy of pathological nasopharyngeal tissues,” J. Raman Spectrosc. 46(6), 537–544 (2015).
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J. Thorac. Oncol. (2)

M. A. Short, S. Lam, A. M. McWilliams, D. N. Ionescu, and H. Zeng, “Using Laser Raman Spectroscopy to Reduce False Positives of Autofluorescence Bronchoscopies: A Pilot Study,” J. Thorac. Oncol. 6(7), 1206–1214 (2011).
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J. Vasc. Interv. Radiol. (1)

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Lasers Med. Sci. (1)

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Lasers Surg. Med. (2)

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D. P. Lau, Z. Huang, H. Lui, C. S. Man, K. Berean, M. Morrison, and H. Zeng, “Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx-preliminary findings,” Lasers Surg. Med. 32(3), 210–214 (2003).
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Figures (5)

Fig. 1.
Fig. 1. (a) The mean ± standard deviations (SD) of normalized spectra in cancerous tissue of the Pre-MWA group, Post-MWA group and healthy group, shading area represents standard deviations. (b) The differential spectra calculated from the mean Raman spectra between the cancerous tissue of Pre-MWA group and Post-MWA groups.
Fig. 2.
Fig. 2. Scatter plots of the diagnostically significantly principal components scores for the three types of tissue, (a) PC1 versus PC2; (b) PC1 versus PC3; and (c) PC2 versus PC3.
Fig. 3.
Fig. 3. The PCA loading of PC1, PC2 and PC3.
Fig. 4.
Fig. 4. (a) represents the scatter plot of linear discriminant scores for three types of tissue; (b) displays two-dimensional ternary plot of the posterior probabilities belonging to the Pre-MWA group, Post-MWA group and healthy lung tissue calculated from the Raman spectral data set, using the PCA-LDA discriminant model combined with LOOCV method.
Fig. 5.
Fig. 5. The ROC curves of discrimination results for the Raman spectral classification of Pre-MWA group, Post-MWA group and healthy lung tissue based on PCA-LDA algorithms together with the LOOCV method. AUC: the areas under the ROC curves.

Tables (1)

Tables Icon

Table 1. Discrimination results obtained by Raman spectroscopy of different types of tissues using the classification model based on PCA-LDA algorithms with leave-one-out cross validation method. Actual: Pathological diagnosis results. Predict: Raman spectra combined with the classification model obtained the diagnostic results.