Abstract

In this paper we present a novel approach of realizing a safe, simple, and inexpensive sensor applicable to pigmented lesions detection. The approach is based on temporal tracking of back-reflected secondary speckle patterns generated while illuminating the affected area with a laser and applying periodic pressure to the surface via a controlled vibration source. When applied to pigmented lesions, the technique is superior to visual examination in avoiding many false positives and resultant unnecessary biopsies. Applying a series of different vibration frequencies at the examined tissue and analyzing the 2-D time varying speckle patterns in response to the applied periodic pressure creates a unique signature for each and different pigmented lesion. Analyzing these signatures is the first step toward detection of malignant melanoma. In this paper we present preliminary experiments that show the validity of the developed sensor for the classification of pigmented lesions.

© 2016 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Optical detection and monitoring of pigmented skin lesions

J. J. Stamnes, G. Ryzhikov, M. Biryulina, B. Hamre, L. Zhao, and K. Stamnes
Biomed. Opt. Express 8(6) 2946-2964 (2017)

Optical tissue probing: human skin hydration detection by speckle patterns analysis

Yarden Tzabari Kelman, Sagie Asraf, Nisan Ozana, Nadav Shabairou, and Zeev Zalevsky
Biomed. Opt. Express 10(9) 4874-4883 (2019)

Analysis of skin lesions using laminar optical tomography

Timothy J. Muldoon, Sean A. Burgess, Brenda R. Chen, Désirée Ratner, and Elizabeth M. C. Hillman
Biomed. Opt. Express 3(7) 1701-1712 (2012)

References

  • View by:
  • |
  • |
  • |

  1. J. Y. Lin and D. E. Fisher, “Melanocyte biology and skin pigmentation,” Nature 445(7130), 843–850 (2007).
    [Crossref] [PubMed]
  2. M. Watson, “Drugs in Clinical Development for Melanoma,” Pharmaceut. Med. 26(3), 171–183 (2012).
    [Crossref]
  3. F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
    [Crossref] [PubMed]
  4. A. H. Sam and J. T. H. Teo, Rapid Medicine (London: Wiley-Blackwell 2010)
  5. A. L. Breton, M. Amini-Adle, G. Duru, N. Poulalhon, S. Dalle, and L. Thomas, “Overview of the use of dermoscopy in academic and non-academic hospital centres in France: a nationwide survey,” J. Eur. Acad. Dermatol. Venereol. 28(9), 1207–1213 (2014).
    [Crossref] [PubMed]
  6. A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, “In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry,” Cancer Res. 72(11), 2738–2745 (2012).
    [Crossref] [PubMed]
  7. C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
    [Crossref] [PubMed]
  8. Y. Pan, D. S. Gareau, A. Scope, M. Rajadhyaksha, N. A. Mullani, and A. A. Marghoob, “Polarized and nonpolarized dermoscopy: the explanation for the observed differences,” Arch. Dermatol. 144(6), 828–829 (2008).
    [Crossref] [PubMed]
  9. A. A. Marghoob, L. Cowell, A. W. Kopf, and A. Scope, “Observation of chrysalis structures with polarized dermoscopy,” Arch. Dermatol. 145(5), 618 (2009).
    [Crossref] [PubMed]
  10. R. Satta, L. Fresi, and F. Cottoni, “Dermoscopic rainbow pattern in Kaposi’s sarcoma lesions: our experience,” Arch. Dermatol. 148(10), 1207–1208 (2012).
    [Crossref] [PubMed]
  11. S. Q. Wang, S. W. Dusza, A. Scope, R. P. Braun, A. W. Kopf, and A. A. Marghoob, “Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study,” Dermatol. Surg. 34(10), 1389–1395 (2008).
    [PubMed]
  12. American Cancer Society (ACS), http://www.cancer.org/cancer/skincancer/melanoma
  13. Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
    [Crossref] [PubMed]
  14. L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
    [Crossref] [PubMed]
  15. L. Lovatto, C. Carrera, G. Salerni, L. Alós, J. Malvehy, and S. Puig, “In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up,” J. Eur. Acad. Dermatol. Venereol. 29(10), 1918–1925 (2015).
    [Crossref] [PubMed]
  16. J. Zhao, H. Zeng, D. McLean, S. Kalia, and H. Lui, “Recent Advances in Real-Time Raman Spectroscopy for In Vivo Skin Cancer Diagnosis,” Optics in the Life Sciences, BT4A.6 (2015).
  17. M. Amouroux, W. C. P. M. Blondel, F. Granel-Brocard, F. Marchal, and F. Guillemin, “A preliminary study on skin phantoms to test spatially resolved-diffuse reflectance spectroscopy as a tool to help diagnose cutaneous melanoma: A non-invasive measurement of Breslow index,” Biomed. Mater. Eng. 18(4-5), 339–343 (2008).
    [PubMed]
  18. X. Jia, H. Huang, and R. Wang, “A novel edge detection in medical images by fusing of multi-model from different spatial structure clues,” Biomed. Mater. Eng. 24(1), 1289–1298 (2014).
    [PubMed]
  19. C. A. Agudelo and T. Yamaoka, “Magnetic resonance imaging detection of an uncommon granuloma formation after endothelial progenitor cells transplantation,” Biomed. Mater. Eng. 23(6), 555–566 (2013).
    [PubMed]
  20. G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
    [Crossref] [PubMed]
  21. J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
    [Crossref] [PubMed]
  22. T. D. Wang and J. Van Dam, “Optical biopsy: a new frontier in endoscopic detection and diagnosis,” Clin. Gastroenterol. Hepatol. 2(9), 744–753 (2004).
    [Crossref] [PubMed]
  23. J.-T. Oh, M.-L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 034032 (2006).
    [Crossref] [PubMed]
  24. H. Makhlouf, A. R. Rouse, and A. F. Gmitro, “Dual modality fluorescence confocal and spectral-domain optical coherence tomography microendoscope,” Biomed. Opt. Express 2(3), 634–644 (2011).
    [Crossref] [PubMed]
  25. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
    [Crossref] [PubMed]
  26. J. G. Fujimoto, C. Pitris, S. A. Boppart, and M. E. Brezinski, “Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy,” Neoplasia 2(1-2), 9–25 (2000).
    [Crossref] [PubMed]
  27. A. L. Clark, A. M. Gillenwater, T. G. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, and R. R. Richards-Kortum, “Confocal microscopy for real-time detection of oral cavity neoplasia,” Clin. Cancer Res. 9(13), 4714–4721 (2003).
    [PubMed]
  28. P. E. Paull, B. J. Hyatt, W. Wassef, and A. H. Fischer, “Confocal laser endomicroscopy: a primer for pathologists,” Arch. Pathol. Lab. Med. 135(10), 1343–1348 (2011).
    [Crossref] [PubMed]
  29. D. Zink, A. H. Fischer, and J. A. Nickerson, “Nuclear structure in cancer cells,” Nat. Rev. Cancer 4(9), 677–687 (2004).
    [Crossref] [PubMed]
  30. S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
    [Crossref] [PubMed]
  31. P. Jorgensen, N. P. Edgington, B. L. Schneider, I. Rupes, M. Tyers, and B. Futcher, “The size of the nucleus increases as yeast cells grow,” Mol. Biol. Cell 18(9), 3523–3532 (2007).
    [Crossref] [PubMed]
  32. A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, “In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry,” J. Biomed. Opt. 16(2), 020501 (2011).
    [Crossref] [PubMed]
  33. M. Pirtini Çetingül and C. Herman, “Quantification of the thermal signature of a melanoma lesion,” Int. J. Therm. Sci. 50(4), 421–431 (2011).
    [Crossref]
  34. A. Safrani, O. Aharon, S. Mor, O. Arnon, L. Rosenberg, and I. Abdulhalim, “Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals,” J. Biomed. Opt. 15(2), 026024 (2010).
    [Crossref] [PubMed]
  35. O. Aharon, I. Abdulhalim, O. Arnon, L. Rosenberg, V. Dyomin, and E. Silberstein, “Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging,” J. Biomed. Opt. 16(8), 086008 (2011).
    [Crossref] [PubMed]
  36. L. Graham, Y. Yitzhaky, and I. Abdulhalim, “Classification of skin moles from optical spectropolarimetric images: a pilot study,” J. Biomed. Opt. 18(11), 111403 (2013).
    [Crossref] [PubMed]
  37. Y. Bishitz, N. Ozana, Y. Beiderman, F. Tenner, M. Schmidt, V. Mico, J. Garcia, and Z. Zalevsky, “Noncontact optical sensor for bone fracture diagnostics,” Biomed. Opt. Express 6(3), 651–657 (2015).
    [Crossref] [PubMed]
  38. Y. Beiderman, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Optical technique for classification, recognition and identification of obscured objects,” Opt. Commun. 283(21), 4274–4282 (2010).
    [Crossref]
  39. Z. Zalevsky, Y. Beiderman, I. Margalit, S. Gingold, M. Teicher, V. Mico, and J. Garcia, “Simultaneous remote extraction of multiple speech sources and heart beats from secondary speckles pattern,” Opt. Express 17(24), 21566–21580 (2009).
    [Crossref] [PubMed]
  40. Y. Beiderman, R. Blumenberg, N. Rabani, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood,” Biomed. Opt. Express 2(4), 858–870 (2011).
    [Crossref] [PubMed]
  41. N. Ozana, N. Arbel, Y. Beiderman, V. Mico, M. Sanz, J. Garcia, A. Anand, B. Javidi, Y. Epstein, and Z. Zalevsky, “Improved noncontact optical sensor for detection of glucose concentration and indication of dehydration level,” Biomed. Opt. Express 5(6), 1926–1940 (2014).
    [Crossref] [PubMed]
  42. A. Shenhav, Z. Brodie, Y. Beiderman, J. Garcia, V. Mico, and Z. Zalevsky, “Optical sensor for remote estimation of alcohol concentration in blood stream,” Opt. Commun. 289, 149–157 (2013).
    [Crossref]
  43. Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
    [Crossref] [PubMed]
  44. Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).
  45. I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
    [Crossref] [PubMed]

2015 (2)

L. Lovatto, C. Carrera, G. Salerni, L. Alós, J. Malvehy, and S. Puig, “In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up,” J. Eur. Acad. Dermatol. Venereol. 29(10), 1918–1925 (2015).
[Crossref] [PubMed]

Y. Bishitz, N. Ozana, Y. Beiderman, F. Tenner, M. Schmidt, V. Mico, J. Garcia, and Z. Zalevsky, “Noncontact optical sensor for bone fracture diagnostics,” Biomed. Opt. Express 6(3), 651–657 (2015).
[Crossref] [PubMed]

2014 (5)

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

X. Jia, H. Huang, and R. Wang, “A novel edge detection in medical images by fusing of multi-model from different spatial structure clues,” Biomed. Mater. Eng. 24(1), 1289–1298 (2014).
[PubMed]

A. L. Breton, M. Amini-Adle, G. Duru, N. Poulalhon, S. Dalle, and L. Thomas, “Overview of the use of dermoscopy in academic and non-academic hospital centres in France: a nationwide survey,” J. Eur. Acad. Dermatol. Venereol. 28(9), 1207–1213 (2014).
[Crossref] [PubMed]

N. Ozana, N. Arbel, Y. Beiderman, V. Mico, M. Sanz, J. Garcia, A. Anand, B. Javidi, Y. Epstein, and Z. Zalevsky, “Improved noncontact optical sensor for detection of glucose concentration and indication of dehydration level,” Biomed. Opt. Express 5(6), 1926–1940 (2014).
[Crossref] [PubMed]

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

2013 (5)

A. Shenhav, Z. Brodie, Y. Beiderman, J. Garcia, V. Mico, and Z. Zalevsky, “Optical sensor for remote estimation of alcohol concentration in blood stream,” Opt. Commun. 289, 149–157 (2013).
[Crossref]

C. A. Agudelo and T. Yamaoka, “Magnetic resonance imaging detection of an uncommon granuloma formation after endothelial progenitor cells transplantation,” Biomed. Mater. Eng. 23(6), 555–566 (2013).
[PubMed]

J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
[Crossref] [PubMed]

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

L. Graham, Y. Yitzhaky, and I. Abdulhalim, “Classification of skin moles from optical spectropolarimetric images: a pilot study,” J. Biomed. Opt. 18(11), 111403 (2013).
[Crossref] [PubMed]

2012 (5)

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, “In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry,” Cancer Res. 72(11), 2738–2745 (2012).
[Crossref] [PubMed]

M. Watson, “Drugs in Clinical Development for Melanoma,” Pharmaceut. Med. 26(3), 171–183 (2012).
[Crossref]

R. Satta, L. Fresi, and F. Cottoni, “Dermoscopic rainbow pattern in Kaposi’s sarcoma lesions: our experience,” Arch. Dermatol. 148(10), 1207–1208 (2012).
[Crossref] [PubMed]

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

2011 (6)

Y. Beiderman, R. Blumenberg, N. Rabani, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood,” Biomed. Opt. Express 2(4), 858–870 (2011).
[Crossref] [PubMed]

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, “In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry,” J. Biomed. Opt. 16(2), 020501 (2011).
[Crossref] [PubMed]

M. Pirtini Çetingül and C. Herman, “Quantification of the thermal signature of a melanoma lesion,” Int. J. Therm. Sci. 50(4), 421–431 (2011).
[Crossref]

O. Aharon, I. Abdulhalim, O. Arnon, L. Rosenberg, V. Dyomin, and E. Silberstein, “Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging,” J. Biomed. Opt. 16(8), 086008 (2011).
[Crossref] [PubMed]

H. Makhlouf, A. R. Rouse, and A. F. Gmitro, “Dual modality fluorescence confocal and spectral-domain optical coherence tomography microendoscope,” Biomed. Opt. Express 2(3), 634–644 (2011).
[Crossref] [PubMed]

P. E. Paull, B. J. Hyatt, W. Wassef, and A. H. Fischer, “Confocal laser endomicroscopy: a primer for pathologists,” Arch. Pathol. Lab. Med. 135(10), 1343–1348 (2011).
[Crossref] [PubMed]

2010 (3)

A. Safrani, O. Aharon, S. Mor, O. Arnon, L. Rosenberg, and I. Abdulhalim, “Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals,” J. Biomed. Opt. 15(2), 026024 (2010).
[Crossref] [PubMed]

Y. Beiderman, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Optical technique for classification, recognition and identification of obscured objects,” Opt. Commun. 283(21), 4274–4282 (2010).
[Crossref]

Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
[Crossref] [PubMed]

2009 (2)

2008 (3)

M. Amouroux, W. C. P. M. Blondel, F. Granel-Brocard, F. Marchal, and F. Guillemin, “A preliminary study on skin phantoms to test spatially resolved-diffuse reflectance spectroscopy as a tool to help diagnose cutaneous melanoma: A non-invasive measurement of Breslow index,” Biomed. Mater. Eng. 18(4-5), 339–343 (2008).
[PubMed]

S. Q. Wang, S. W. Dusza, A. Scope, R. P. Braun, A. W. Kopf, and A. A. Marghoob, “Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study,” Dermatol. Surg. 34(10), 1389–1395 (2008).
[PubMed]

Y. Pan, D. S. Gareau, A. Scope, M. Rajadhyaksha, N. A. Mullani, and A. A. Marghoob, “Polarized and nonpolarized dermoscopy: the explanation for the observed differences,” Arch. Dermatol. 144(6), 828–829 (2008).
[Crossref] [PubMed]

2007 (3)

J. Y. Lin and D. E. Fisher, “Melanocyte biology and skin pigmentation,” Nature 445(7130), 843–850 (2007).
[Crossref] [PubMed]

C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
[Crossref] [PubMed]

P. Jorgensen, N. P. Edgington, B. L. Schneider, I. Rupes, M. Tyers, and B. Futcher, “The size of the nucleus increases as yeast cells grow,” Mol. Biol. Cell 18(9), 3523–3532 (2007).
[Crossref] [PubMed]

2006 (1)

J.-T. Oh, M.-L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 034032 (2006).
[Crossref] [PubMed]

2004 (2)

D. Zink, A. H. Fischer, and J. A. Nickerson, “Nuclear structure in cancer cells,” Nat. Rev. Cancer 4(9), 677–687 (2004).
[Crossref] [PubMed]

T. D. Wang and J. Van Dam, “Optical biopsy: a new frontier in endoscopic detection and diagnosis,” Clin. Gastroenterol. Hepatol. 2(9), 744–753 (2004).
[Crossref] [PubMed]

2003 (1)

A. L. Clark, A. M. Gillenwater, T. G. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, and R. R. Richards-Kortum, “Confocal microscopy for real-time detection of oral cavity neoplasia,” Clin. Cancer Res. 9(13), 4714–4721 (2003).
[PubMed]

2000 (1)

J. G. Fujimoto, C. Pitris, S. A. Boppart, and M. E. Brezinski, “Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy,” Neoplasia 2(1-2), 9–25 (2000).
[Crossref] [PubMed]

1998 (2)

S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
[Crossref] [PubMed]

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Abdulhalim, I.

L. Graham, Y. Yitzhaky, and I. Abdulhalim, “Classification of skin moles from optical spectropolarimetric images: a pilot study,” J. Biomed. Opt. 18(11), 111403 (2013).
[Crossref] [PubMed]

O. Aharon, I. Abdulhalim, O. Arnon, L. Rosenberg, V. Dyomin, and E. Silberstein, “Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging,” J. Biomed. Opt. 16(8), 086008 (2011).
[Crossref] [PubMed]

A. Safrani, O. Aharon, S. Mor, O. Arnon, L. Rosenberg, and I. Abdulhalim, “Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals,” J. Biomed. Opt. 15(2), 026024 (2010).
[Crossref] [PubMed]

Agero, A. L. C.

C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
[Crossref] [PubMed]

Agudelo, C. A.

C. A. Agudelo and T. Yamaoka, “Magnetic resonance imaging detection of an uncommon granuloma formation after endothelial progenitor cells transplantation,” Biomed. Mater. Eng. 23(6), 555–566 (2013).
[PubMed]

Aharon, O.

O. Aharon, I. Abdulhalim, O. Arnon, L. Rosenberg, V. Dyomin, and E. Silberstein, “Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging,” J. Biomed. Opt. 16(8), 086008 (2011).
[Crossref] [PubMed]

A. Safrani, O. Aharon, S. Mor, O. Arnon, L. Rosenberg, and I. Abdulhalim, “Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals,” J. Biomed. Opt. 15(2), 026024 (2010).
[Crossref] [PubMed]

Akilov, O.

J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
[Crossref] [PubMed]

Alijagic, S.

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

Alizadeh-Naderi, R.

A. L. Clark, A. M. Gillenwater, T. G. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, and R. R. Richards-Kortum, “Confocal microscopy for real-time detection of oral cavity neoplasia,” Clin. Cancer Res. 9(13), 4714–4721 (2003).
[PubMed]

Alós, L.

L. Lovatto, C. Carrera, G. Salerni, L. Alós, J. Malvehy, and S. Puig, “In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up,” J. Eur. Acad. Dermatol. Venereol. 29(10), 1918–1925 (2015).
[Crossref] [PubMed]

Amini-Adle, M.

A. L. Breton, M. Amini-Adle, G. Duru, N. Poulalhon, S. Dalle, and L. Thomas, “Overview of the use of dermoscopy in academic and non-academic hospital centres in France: a nationwide survey,” J. Eur. Acad. Dermatol. Venereol. 28(9), 1207–1213 (2014).
[Crossref] [PubMed]

Amouroux, M.

M. Amouroux, W. C. P. M. Blondel, F. Granel-Brocard, F. Marchal, and F. Guillemin, “A preliminary study on skin phantoms to test spatially resolved-diffuse reflectance spectroscopy as a tool to help diagnose cutaneous melanoma: A non-invasive measurement of Breslow index,” Biomed. Mater. Eng. 18(4-5), 339–343 (2008).
[PubMed]

Anand, A.

Apalla, Z.

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

Arbel, N.

Argenziano, G.

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

Arnon, O.

O. Aharon, I. Abdulhalim, O. Arnon, L. Rosenberg, V. Dyomin, and E. Silberstein, “Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging,” J. Biomed. Opt. 16(8), 086008 (2011).
[Crossref] [PubMed]

A. Safrani, O. Aharon, S. Mor, O. Arnon, L. Rosenberg, and I. Abdulhalim, “Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals,” J. Biomed. Opt. 15(2), 026024 (2010).
[Crossref] [PubMed]

Badenas, C.

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

Beiderman, Y.

Y. Bishitz, N. Ozana, Y. Beiderman, F. Tenner, M. Schmidt, V. Mico, J. Garcia, and Z. Zalevsky, “Noncontact optical sensor for bone fracture diagnostics,” Biomed. Opt. Express 6(3), 651–657 (2015).
[Crossref] [PubMed]

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

N. Ozana, N. Arbel, Y. Beiderman, V. Mico, M. Sanz, J. Garcia, A. Anand, B. Javidi, Y. Epstein, and Z. Zalevsky, “Improved noncontact optical sensor for detection of glucose concentration and indication of dehydration level,” Biomed. Opt. Express 5(6), 1926–1940 (2014).
[Crossref] [PubMed]

A. Shenhav, Z. Brodie, Y. Beiderman, J. Garcia, V. Mico, and Z. Zalevsky, “Optical sensor for remote estimation of alcohol concentration in blood stream,” Opt. Commun. 289, 149–157 (2013).
[Crossref]

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

Y. Beiderman, R. Blumenberg, N. Rabani, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood,” Biomed. Opt. Express 2(4), 858–870 (2011).
[Crossref] [PubMed]

Y. Beiderman, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Optical technique for classification, recognition and identification of obscured objects,” Opt. Commun. 283(21), 4274–4282 (2010).
[Crossref]

Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
[Crossref] [PubMed]

Z. Zalevsky, Y. Beiderman, I. Margalit, S. Gingold, M. Teicher, V. Mico, and J. Garcia, “Simultaneous remote extraction of multiple speech sources and heart beats from secondary speckles pattern,” Opt. Express 17(24), 21566–21580 (2009).
[Crossref] [PubMed]

Belkin, M.

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

Benvenuto-Andrade, C.

C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
[Crossref] [PubMed]

Bhaumik, A.

S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
[Crossref] [PubMed]

Bishitz, Y.

Bissell, M. J.

S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
[Crossref] [PubMed]

Blondel, W. C. P. M.

M. Amouroux, W. C. P. M. Blondel, F. Granel-Brocard, F. Marchal, and F. Guillemin, “A preliminary study on skin phantoms to test spatially resolved-diffuse reflectance spectroscopy as a tool to help diagnose cutaneous melanoma: A non-invasive measurement of Breslow index,” Biomed. Mater. Eng. 18(4-5), 339–343 (2008).
[PubMed]

Blumenberg, R.

Boppart, S. A.

J. G. Fujimoto, C. Pitris, S. A. Boppart, and M. E. Brezinski, “Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy,” Neoplasia 2(1-2), 9–25 (2000).
[Crossref] [PubMed]

Braun, R. P.

S. Q. Wang, S. W. Dusza, A. Scope, R. P. Braun, A. W. Kopf, and A. A. Marghoob, “Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study,” Dermatol. Surg. 34(10), 1389–1395 (2008).
[PubMed]

Breton, A. L.

A. L. Breton, M. Amini-Adle, G. Duru, N. Poulalhon, S. Dalle, and L. Thomas, “Overview of the use of dermoscopy in academic and non-academic hospital centres in France: a nationwide survey,” J. Eur. Acad. Dermatol. Venereol. 28(9), 1207–1213 (2014).
[Crossref] [PubMed]

Brezinski, M. E.

J. G. Fujimoto, C. Pitris, S. A. Boppart, and M. E. Brezinski, “Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy,” Neoplasia 2(1-2), 9–25 (2000).
[Crossref] [PubMed]

Brodie, Z.

A. Shenhav, Z. Brodie, Y. Beiderman, J. Garcia, V. Mico, and Z. Zalevsky, “Optical sensor for remote estimation of alcohol concentration in blood stream,” Opt. Commun. 289, 149–157 (2013).
[Crossref]

Burg, G.

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

Burshtein, N.

Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
[Crossref] [PubMed]

Carrera, C.

L. Lovatto, C. Carrera, G. Salerni, L. Alós, J. Malvehy, and S. Puig, “In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up,” J. Eur. Acad. Dermatol. Venereol. 29(10), 1918–1925 (2015).
[Crossref] [PubMed]

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Cho-Vega, J. H.

A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, “In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry,” Cancer Res. 72(11), 2738–2745 (2012).
[Crossref] [PubMed]

Clark, A. L.

A. L. Clark, A. M. Gillenwater, T. G. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, and R. R. Richards-Kortum, “Confocal microscopy for real-time detection of oral cavity neoplasia,” Clin. Cancer Res. 9(13), 4714–4721 (2003).
[PubMed]

Collier, T. G.

A. L. Clark, A. M. Gillenwater, T. G. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, and R. R. Richards-Kortum, “Confocal microscopy for real-time detection of oral cavity neoplasia,” Clin. Cancer Res. 9(13), 4714–4721 (2003).
[PubMed]

Cottoni, F.

R. Satta, L. Fresi, and F. Cottoni, “Dermoscopic rainbow pattern in Kaposi’s sarcoma lesions: our experience,” Arch. Dermatol. 148(10), 1207–1208 (2012).
[Crossref] [PubMed]

Cowell, L.

A. A. Marghoob, L. Cowell, A. W. Kopf, and A. Scope, “Observation of chrysalis structures with polarized dermoscopy,” Arch. Dermatol. 145(5), 618 (2009).
[Crossref] [PubMed]

Dalle, S.

A. L. Breton, M. Amini-Adle, G. Duru, N. Poulalhon, S. Dalle, and L. Thomas, “Overview of the use of dermoscopy in academic and non-academic hospital centres in France: a nationwide survey,” J. Eur. Acad. Dermatol. Venereol. 28(9), 1207–1213 (2014).
[Crossref] [PubMed]

Dummer, R.

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

Duru, G.

A. L. Breton, M. Amini-Adle, G. Duru, N. Poulalhon, S. Dalle, and L. Thomas, “Overview of the use of dermoscopy in academic and non-academic hospital centres in France: a nationwide survey,” J. Eur. Acad. Dermatol. Venereol. 28(9), 1207–1213 (2014).
[Crossref] [PubMed]

Dusza, S. W.

S. Q. Wang, S. W. Dusza, A. Scope, R. P. Braun, A. W. Kopf, and A. A. Marghoob, “Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study,” Dermatol. Surg. 34(10), 1389–1395 (2008).
[PubMed]

C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
[Crossref] [PubMed]

Duvic, M.

A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, “In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry,” Cancer Res. 72(11), 2738–2745 (2012).
[Crossref] [PubMed]

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, “In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry,” J. Biomed. Opt. 16(2), 020501 (2011).
[Crossref] [PubMed]

Dyomin, V.

O. Aharon, I. Abdulhalim, O. Arnon, L. Rosenberg, V. Dyomin, and E. Silberstein, “Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging,” J. Biomed. Opt. 16(8), 086008 (2011).
[Crossref] [PubMed]

Edgington, N. P.

P. Jorgensen, N. P. Edgington, B. L. Schneider, I. Rupes, M. Tyers, and B. Futcher, “The size of the nucleus increases as yeast cells grow,” Mol. Biol. Cell 18(9), 3523–3532 (2007).
[Crossref] [PubMed]

El-Naggar, A. K.

A. L. Clark, A. M. Gillenwater, T. G. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, and R. R. Richards-Kortum, “Confocal microscopy for real-time detection of oral cavity neoplasia,” Clin. Cancer Res. 9(13), 4714–4721 (2003).
[PubMed]

English, J. C.

J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
[Crossref] [PubMed]

Epstein, Y.

Ferris, L. K.

J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
[Crossref] [PubMed]

Fischer, A. H.

P. E. Paull, B. J. Hyatt, W. Wassef, and A. H. Fischer, “Confocal laser endomicroscopy: a primer for pathologists,” Arch. Pathol. Lab. Med. 135(10), 1343–1348 (2011).
[Crossref] [PubMed]

D. Zink, A. H. Fischer, and J. A. Nickerson, “Nuclear structure in cancer cells,” Nat. Rev. Cancer 4(9), 677–687 (2004).
[Crossref] [PubMed]

Fisher, D. E.

J. Y. Lin and D. E. Fisher, “Melanocyte biology and skin pigmentation,” Nature 445(7130), 843–850 (2007).
[Crossref] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fresi, L.

R. Satta, L. Fresi, and F. Cottoni, “Dermoscopic rainbow pattern in Kaposi’s sarcoma lesions: our experience,” Arch. Dermatol. 148(10), 1207–1208 (2012).
[Crossref] [PubMed]

Fujimoto, J. G.

J. G. Fujimoto, C. Pitris, S. A. Boppart, and M. E. Brezinski, “Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy,” Neoplasia 2(1-2), 9–25 (2000).
[Crossref] [PubMed]

Futcher, B.

P. Jorgensen, N. P. Edgington, B. L. Schneider, I. Rupes, M. Tyers, and B. Futcher, “The size of the nucleus increases as yeast cells grow,” Mol. Biol. Cell 18(9), 3523–3532 (2007).
[Crossref] [PubMed]

Garcia, J.

Y. Bishitz, N. Ozana, Y. Beiderman, F. Tenner, M. Schmidt, V. Mico, J. Garcia, and Z. Zalevsky, “Noncontact optical sensor for bone fracture diagnostics,” Biomed. Opt. Express 6(3), 651–657 (2015).
[Crossref] [PubMed]

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

N. Ozana, N. Arbel, Y. Beiderman, V. Mico, M. Sanz, J. Garcia, A. Anand, B. Javidi, Y. Epstein, and Z. Zalevsky, “Improved noncontact optical sensor for detection of glucose concentration and indication of dehydration level,” Biomed. Opt. Express 5(6), 1926–1940 (2014).
[Crossref] [PubMed]

A. Shenhav, Z. Brodie, Y. Beiderman, J. Garcia, V. Mico, and Z. Zalevsky, “Optical sensor for remote estimation of alcohol concentration in blood stream,” Opt. Commun. 289, 149–157 (2013).
[Crossref]

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

Y. Beiderman, R. Blumenberg, N. Rabani, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood,” Biomed. Opt. Express 2(4), 858–870 (2011).
[Crossref] [PubMed]

Y. Beiderman, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Optical technique for classification, recognition and identification of obscured objects,” Opt. Commun. 283(21), 4274–4282 (2010).
[Crossref]

Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
[Crossref] [PubMed]

Z. Zalevsky, Y. Beiderman, I. Margalit, S. Gingold, M. Teicher, V. Mico, and J. Garcia, “Simultaneous remote extraction of multiple speech sources and heart beats from secondary speckles pattern,” Opt. Express 17(24), 21566–21580 (2009).
[Crossref] [PubMed]

Garcia-Uribe, A.

A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, “In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry,” Cancer Res. 72(11), 2738–2745 (2012).
[Crossref] [PubMed]

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, “In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry,” J. Biomed. Opt. 16(2), 020501 (2011).
[Crossref] [PubMed]

Gareau, D. S.

Y. Pan, D. S. Gareau, A. Scope, M. Rajadhyaksha, N. A. Mullani, and A. A. Marghoob, “Polarized and nonpolarized dermoscopy: the explanation for the observed differences,” Arch. Dermatol. 144(6), 828–829 (2008).
[Crossref] [PubMed]

Gillenwater, A. M.

A. L. Clark, A. M. Gillenwater, T. G. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, and R. R. Richards-Kortum, “Confocal microscopy for real-time detection of oral cavity neoplasia,” Clin. Cancer Res. 9(13), 4714–4721 (2003).
[PubMed]

Gilliet, M.

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

Gingold, S.

Gmitro, A. F.

Grabbe, S.

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

Graham, L.

L. Graham, Y. Yitzhaky, and I. Abdulhalim, “Classification of skin moles from optical spectropolarimetric images: a pilot study,” J. Biomed. Opt. 18(11), 111403 (2013).
[Crossref] [PubMed]

Granel-Brocard, F.

M. Amouroux, W. C. P. M. Blondel, F. Granel-Brocard, F. Marchal, and F. Guillemin, “A preliminary study on skin phantoms to test spatially resolved-diffuse reflectance spectroscopy as a tool to help diagnose cutaneous melanoma: A non-invasive measurement of Breslow index,” Biomed. Mater. Eng. 18(4-5), 339–343 (2008).
[PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Guillemin, F.

M. Amouroux, W. C. P. M. Blondel, F. Granel-Brocard, F. Marchal, and F. Guillemin, “A preliminary study on skin phantoms to test spatially resolved-diffuse reflectance spectroscopy as a tool to help diagnose cutaneous melanoma: A non-invasive measurement of Breslow index,” Biomed. Mater. Eng. 18(4-5), 339–343 (2008).
[PubMed]

Halpern, A. C.

C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
[Crossref] [PubMed]

Haydu, L. E.

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Herman, C.

M. Pirtini Çetingül and C. Herman, “Quantification of the thermal signature of a melanoma lesion,” Int. J. Therm. Sci. 50(4), 421–431 (2011).
[Crossref]

Ho, J.

J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
[Crossref] [PubMed]

Horovitz, I.

Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
[Crossref] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Huang, H.

X. Jia, H. Huang, and R. Wang, “A novel edge detection in medical images by fusing of multi-model from different spatial structure clues,” Biomed. Mater. Eng. 24(1), 1289–1298 (2014).
[PubMed]

Hyatt, B. J.

P. E. Paull, B. J. Hyatt, W. Wassef, and A. H. Fischer, “Confocal laser endomicroscopy: a primer for pathologists,” Arch. Pathol. Lab. Med. 135(10), 1343–1348 (2011).
[Crossref] [PubMed]

Javidi, B.

Jia, X.

X. Jia, H. Huang, and R. Wang, “A novel edge detection in medical images by fusing of multi-model from different spatial structure clues,” Biomed. Mater. Eng. 24(1), 1289–1298 (2014).
[PubMed]

Jorgensen, P.

P. Jorgensen, N. P. Edgington, B. L. Schneider, I. Rupes, M. Tyers, and B. Futcher, “The size of the nucleus increases as yeast cells grow,” Mol. Biol. Cell 18(9), 3523–3532 (2007).
[Crossref] [PubMed]

Kefford, R. F.

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

Kopf, A. W.

A. A. Marghoob, L. Cowell, A. W. Kopf, and A. Scope, “Observation of chrysalis structures with polarized dermoscopy,” Arch. Dermatol. 145(5), 618 (2009).
[Crossref] [PubMed]

S. Q. Wang, S. W. Dusza, A. Scope, R. P. Braun, A. W. Kopf, and A. A. Marghoob, “Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study,” Dermatol. Surg. 34(10), 1389–1395 (2008).
[PubMed]

Lallas, A.

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

Larabell, C. A.

S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
[Crossref] [PubMed]

Lelièvre, S. A.

S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
[Crossref] [PubMed]

Li, M.-L.

J.-T. Oh, M.-L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 034032 (2006).
[Crossref] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Lin, J. Y.

J. Y. Lin and D. E. Fisher, “Melanocyte biology and skin pigmentation,” Nature 445(7130), 843–850 (2007).
[Crossref] [PubMed]

Long, G. V.

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

Longo, C.

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

Lovatto, L.

L. Lovatto, C. Carrera, G. Salerni, L. Alós, J. Malvehy, and S. Puig, “In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up,” J. Eur. Acad. Dermatol. Venereol. 29(10), 1918–1925 (2015).
[Crossref] [PubMed]

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

Makhlouf, H.

Malvehy, J.

L. Lovatto, C. Carrera, G. Salerni, L. Alós, J. Malvehy, and S. Puig, “In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up,” J. Eur. Acad. Dermatol. Venereol. 29(10), 1918–1925 (2015).
[Crossref] [PubMed]

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

Marchal, F.

M. Amouroux, W. C. P. M. Blondel, F. Granel-Brocard, F. Marchal, and F. Guillemin, “A preliminary study on skin phantoms to test spatially resolved-diffuse reflectance spectroscopy as a tool to help diagnose cutaneous melanoma: A non-invasive measurement of Breslow index,” Biomed. Mater. Eng. 18(4-5), 339–343 (2008).
[PubMed]

Margalit, I.

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

Z. Zalevsky, Y. Beiderman, I. Margalit, S. Gingold, M. Teicher, V. Mico, and J. Garcia, “Simultaneous remote extraction of multiple speech sources and heart beats from secondary speckles pattern,” Opt. Express 17(24), 21566–21580 (2009).
[Crossref] [PubMed]

Marghoob, A. A.

A. A. Marghoob, L. Cowell, A. W. Kopf, and A. Scope, “Observation of chrysalis structures with polarized dermoscopy,” Arch. Dermatol. 145(5), 618 (2009).
[Crossref] [PubMed]

S. Q. Wang, S. W. Dusza, A. Scope, R. P. Braun, A. W. Kopf, and A. A. Marghoob, “Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study,” Dermatol. Surg. 34(10), 1389–1395 (2008).
[PubMed]

Y. Pan, D. S. Gareau, A. Scope, M. Rajadhyaksha, N. A. Mullani, and A. A. Marghoob, “Polarized and nonpolarized dermoscopy: the explanation for the observed differences,” Arch. Dermatol. 144(6), 828–829 (2008).
[Crossref] [PubMed]

C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
[Crossref] [PubMed]

Maslov, K.

J.-T. Oh, M.-L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 034032 (2006).
[Crossref] [PubMed]

Menzies, A. M.

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

Mico, V.

Y. Bishitz, N. Ozana, Y. Beiderman, F. Tenner, M. Schmidt, V. Mico, J. Garcia, and Z. Zalevsky, “Noncontact optical sensor for bone fracture diagnostics,” Biomed. Opt. Express 6(3), 651–657 (2015).
[Crossref] [PubMed]

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

N. Ozana, N. Arbel, Y. Beiderman, V. Mico, M. Sanz, J. Garcia, A. Anand, B. Javidi, Y. Epstein, and Z. Zalevsky, “Improved noncontact optical sensor for detection of glucose concentration and indication of dehydration level,” Biomed. Opt. Express 5(6), 1926–1940 (2014).
[Crossref] [PubMed]

A. Shenhav, Z. Brodie, Y. Beiderman, J. Garcia, V. Mico, and Z. Zalevsky, “Optical sensor for remote estimation of alcohol concentration in blood stream,” Opt. Commun. 289, 149–157 (2013).
[Crossref]

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

Y. Beiderman, R. Blumenberg, N. Rabani, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood,” Biomed. Opt. Express 2(4), 858–870 (2011).
[Crossref] [PubMed]

Y. Beiderman, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Optical technique for classification, recognition and identification of obscured objects,” Opt. Commun. 283(21), 4274–4282 (2010).
[Crossref]

Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
[Crossref] [PubMed]

Z. Zalevsky, Y. Beiderman, I. Margalit, S. Gingold, M. Teicher, V. Mico, and J. Garcia, “Simultaneous remote extraction of multiple speech sources and heart beats from secondary speckles pattern,” Opt. Express 17(24), 21566–21580 (2009).
[Crossref] [PubMed]

Mor, S.

A. Safrani, O. Aharon, S. Mor, O. Arnon, L. Rosenberg, and I. Abdulhalim, “Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals,” J. Biomed. Opt. 15(2), 026024 (2010).
[Crossref] [PubMed]

Moreau, J. F.

J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
[Crossref] [PubMed]

Moscarella, E.

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

Mullani, N. A.

Y. Pan, D. S. Gareau, A. Scope, M. Rajadhyaksha, N. A. Mullani, and A. A. Marghoob, “Polarized and nonpolarized dermoscopy: the explanation for the observed differences,” Arch. Dermatol. 144(6), 828–829 (2008).
[Crossref] [PubMed]

Nestle, F. O.

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

Nickerson, J. A.

D. Zink, A. H. Fischer, and J. A. Nickerson, “Nuclear structure in cancer cells,” Nat. Rev. Cancer 4(9), 677–687 (2004).
[Crossref] [PubMed]

S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
[Crossref] [PubMed]

Oh, J.-T.

J.-T. Oh, M.-L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 034032 (2006).
[Crossref] [PubMed]

Ozana, N.

Pan, Y.

Y. Pan, D. S. Gareau, A. Scope, M. Rajadhyaksha, N. A. Mullani, and A. A. Marghoob, “Polarized and nonpolarized dermoscopy: the explanation for the observed differences,” Arch. Dermatol. 144(6), 828–829 (2008).
[Crossref] [PubMed]

Patton, T.

J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
[Crossref] [PubMed]

Paull, P. E.

P. E. Paull, B. J. Hyatt, W. Wassef, and A. H. Fischer, “Confocal laser endomicroscopy: a primer for pathologists,” Arch. Pathol. Lab. Med. 135(10), 1343–1348 (2011).
[Crossref] [PubMed]

Petersen, O. W.

S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
[Crossref] [PubMed]

Piana, S.

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

Pirtini Çetingül, M.

M. Pirtini Çetingül and C. Herman, “Quantification of the thermal signature of a melanoma lesion,” Int. J. Therm. Sci. 50(4), 421–431 (2011).
[Crossref]

Pitris, C.

J. G. Fujimoto, C. Pitris, S. A. Boppart, and M. E. Brezinski, “Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy,” Neoplasia 2(1-2), 9–25 (2000).
[Crossref] [PubMed]

Plana, E.

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

Poulalhon, N.

A. L. Breton, M. Amini-Adle, G. Duru, N. Poulalhon, S. Dalle, and L. Thomas, “Overview of the use of dermoscopy in academic and non-academic hospital centres in France: a nationwide survey,” J. Eur. Acad. Dermatol. Venereol. 28(9), 1207–1213 (2014).
[Crossref] [PubMed]

Prieto, V.

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, “In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry,” J. Biomed. Opt. 16(2), 020501 (2011).
[Crossref] [PubMed]

Prieto, V. G.

A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, “In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry,” Cancer Res. 72(11), 2738–2745 (2012).
[Crossref] [PubMed]

Puig, S.

L. Lovatto, C. Carrera, G. Salerni, L. Alós, J. Malvehy, and S. Puig, “In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up,” J. Eur. Acad. Dermatol. Venereol. 29(10), 1918–1925 (2015).
[Crossref] [PubMed]

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

Puig-Butille, J. A.

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Rabani, N.

Rajadhyaksha, M.

Y. Pan, D. S. Gareau, A. Scope, M. Rajadhyaksha, N. A. Mullani, and A. A. Marghoob, “Polarized and nonpolarized dermoscopy: the explanation for the observed differences,” Arch. Dermatol. 144(6), 828–829 (2008).
[Crossref] [PubMed]

C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
[Crossref] [PubMed]

Ricci, C.

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

Richards-Kortum, R. R.

A. L. Clark, A. M. Gillenwater, T. G. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, and R. R. Richards-Kortum, “Confocal microscopy for real-time detection of oral cavity neoplasia,” Clin. Cancer Res. 9(13), 4714–4721 (2003).
[PubMed]

Rosenberg, L.

O. Aharon, I. Abdulhalim, O. Arnon, L. Rosenberg, V. Dyomin, and E. Silberstein, “Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging,” J. Biomed. Opt. 16(8), 086008 (2011).
[Crossref] [PubMed]

A. Safrani, O. Aharon, S. Mor, O. Arnon, L. Rosenberg, and I. Abdulhalim, “Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals,” J. Biomed. Opt. 15(2), 026024 (2010).
[Crossref] [PubMed]

Rosenfeld, E.

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

Rouse, A. R.

Rupes, I.

P. Jorgensen, N. P. Edgington, B. L. Schneider, I. Rupes, M. Tyers, and B. Futcher, “The size of the nucleus increases as yeast cells grow,” Mol. Biol. Cell 18(9), 3523–3532 (2007).
[Crossref] [PubMed]

Safrani, A.

A. Safrani, O. Aharon, S. Mor, O. Arnon, L. Rosenberg, and I. Abdulhalim, “Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals,” J. Biomed. Opt. 15(2), 026024 (2010).
[Crossref] [PubMed]

Salerni, G.

L. Lovatto, C. Carrera, G. Salerni, L. Alós, J. Malvehy, and S. Puig, “In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up,” J. Eur. Acad. Dermatol. Venereol. 29(10), 1918–1925 (2015).
[Crossref] [PubMed]

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

Sanz, M.

Satta, R.

R. Satta, L. Fresi, and F. Cottoni, “Dermoscopic rainbow pattern in Kaposi’s sarcoma lesions: our experience,” Arch. Dermatol. 148(10), 1207–1208 (2012).
[Crossref] [PubMed]

Schadendorf, D.

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

Schmidt, M.

Schneider, B. L.

P. Jorgensen, N. P. Edgington, B. L. Schneider, I. Rupes, M. Tyers, and B. Futcher, “The size of the nucleus increases as yeast cells grow,” Mol. Biol. Cell 18(9), 3523–3532 (2007).
[Crossref] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Scolyer, R. A.

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

Scope, A.

A. A. Marghoob, L. Cowell, A. W. Kopf, and A. Scope, “Observation of chrysalis structures with polarized dermoscopy,” Arch. Dermatol. 145(5), 618 (2009).
[Crossref] [PubMed]

S. Q. Wang, S. W. Dusza, A. Scope, R. P. Braun, A. W. Kopf, and A. A. Marghoob, “Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study,” Dermatol. Surg. 34(10), 1389–1395 (2008).
[PubMed]

Y. Pan, D. S. Gareau, A. Scope, M. Rajadhyaksha, N. A. Mullani, and A. A. Marghoob, “Polarized and nonpolarized dermoscopy: the explanation for the observed differences,” Arch. Dermatol. 144(6), 828–829 (2008).
[Crossref] [PubMed]

C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
[Crossref] [PubMed]

Shenhav, A.

A. Shenhav, Z. Brodie, Y. Beiderman, J. Garcia, V. Mico, and Z. Zalevsky, “Optical sensor for remote estimation of alcohol concentration in blood stream,” Opt. Commun. 289, 149–157 (2013).
[Crossref]

Silberstein, E.

O. Aharon, I. Abdulhalim, O. Arnon, L. Rosenberg, V. Dyomin, and E. Silberstein, “Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging,” J. Biomed. Opt. 16(8), 086008 (2011).
[Crossref] [PubMed]

Skaat, A.

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

Smith, E. B.

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, “In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry,” J. Biomed. Opt. 16(2), 020501 (2011).
[Crossref] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Stoica, G.

J.-T. Oh, M.-L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 034032 (2006).
[Crossref] [PubMed]

Sun, Y.

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Teicher, M.

Y. Beiderman, R. Blumenberg, N. Rabani, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood,” Biomed. Opt. Express 2(4), 858–870 (2011).
[Crossref] [PubMed]

Y. Beiderman, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Optical technique for classification, recognition and identification of obscured objects,” Opt. Commun. 283(21), 4274–4282 (2010).
[Crossref]

Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
[Crossref] [PubMed]

Z. Zalevsky, Y. Beiderman, I. Margalit, S. Gingold, M. Teicher, V. Mico, and J. Garcia, “Simultaneous remote extraction of multiple speech sources and heart beats from secondary speckles pattern,” Opt. Express 17(24), 21566–21580 (2009).
[Crossref] [PubMed]

Tenner, F.

Thomas, L.

A. L. Breton, M. Amini-Adle, G. Duru, N. Poulalhon, S. Dalle, and L. Thomas, “Overview of the use of dermoscopy in academic and non-academic hospital centres in France: a nationwide survey,” J. Eur. Acad. Dermatol. Venereol. 28(9), 1207–1213 (2014).
[Crossref] [PubMed]

Thompson, J. F.

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

Tornow, R.-P.

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

Tyers, M.

P. Jorgensen, N. P. Edgington, B. L. Schneider, I. Rupes, M. Tyers, and B. Futcher, “The size of the nucleus increases as yeast cells grow,” Mol. Biol. Cell 18(9), 3523–3532 (2007).
[Crossref] [PubMed]

Van Dam, J.

T. D. Wang and J. Van Dam, “Optical biopsy: a new frontier in endoscopic detection and diagnosis,” Clin. Gastroenterol. Hepatol. 2(9), 744–753 (2004).
[Crossref] [PubMed]

Wang, L. V.

A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, “In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry,” Cancer Res. 72(11), 2738–2745 (2012).
[Crossref] [PubMed]

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, “In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry,” J. Biomed. Opt. 16(2), 020501 (2011).
[Crossref] [PubMed]

J.-T. Oh, M.-L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 034032 (2006).
[Crossref] [PubMed]

Wang, R.

X. Jia, H. Huang, and R. Wang, “A novel edge detection in medical images by fusing of multi-model from different spatial structure clues,” Biomed. Mater. Eng. 24(1), 1289–1298 (2014).
[PubMed]

Wang, S. Q.

S. Q. Wang, S. W. Dusza, A. Scope, R. P. Braun, A. W. Kopf, and A. A. Marghoob, “Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study,” Dermatol. Surg. 34(10), 1389–1395 (2008).
[PubMed]

Wang, T. D.

T. D. Wang and J. Van Dam, “Optical biopsy: a new frontier in endoscopic detection and diagnosis,” Clin. Gastroenterol. Hepatol. 2(9), 744–753 (2004).
[Crossref] [PubMed]

Wassef, W.

P. E. Paull, B. J. Hyatt, W. Wassef, and A. H. Fischer, “Confocal laser endomicroscopy: a primer for pathologists,” Arch. Pathol. Lab. Med. 135(10), 1343–1348 (2011).
[Crossref] [PubMed]

Watson, M.

M. Watson, “Drugs in Clinical Development for Melanoma,” Pharmaceut. Med. 26(3), 171–183 (2012).
[Crossref]

Weaver, V. M.

S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
[Crossref] [PubMed]

Wolf, J. A.

J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
[Crossref] [PubMed]

Yamaoka, T.

C. A. Agudelo and T. Yamaoka, “Magnetic resonance imaging detection of an uncommon granuloma formation after endothelial progenitor cells transplantation,” Biomed. Mater. Eng. 23(6), 555–566 (2013).
[PubMed]

Yitzhaky, Y.

L. Graham, Y. Yitzhaky, and I. Abdulhalim, “Classification of skin moles from optical spectropolarimetric images: a pilot study,” J. Biomed. Opt. 18(11), 111403 (2013).
[Crossref] [PubMed]

Zalaudek, I.

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

Zalevsky, Z.

Y. Bishitz, N. Ozana, Y. Beiderman, F. Tenner, M. Schmidt, V. Mico, J. Garcia, and Z. Zalevsky, “Noncontact optical sensor for bone fracture diagnostics,” Biomed. Opt. Express 6(3), 651–657 (2015).
[Crossref] [PubMed]

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

N. Ozana, N. Arbel, Y. Beiderman, V. Mico, M. Sanz, J. Garcia, A. Anand, B. Javidi, Y. Epstein, and Z. Zalevsky, “Improved noncontact optical sensor for detection of glucose concentration and indication of dehydration level,” Biomed. Opt. Express 5(6), 1926–1940 (2014).
[Crossref] [PubMed]

A. Shenhav, Z. Brodie, Y. Beiderman, J. Garcia, V. Mico, and Z. Zalevsky, “Optical sensor for remote estimation of alcohol concentration in blood stream,” Opt. Commun. 289, 149–157 (2013).
[Crossref]

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

Y. Beiderman, R. Blumenberg, N. Rabani, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood,” Biomed. Opt. Express 2(4), 858–870 (2011).
[Crossref] [PubMed]

Y. Beiderman, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Optical technique for classification, recognition and identification of obscured objects,” Opt. Commun. 283(21), 4274–4282 (2010).
[Crossref]

Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
[Crossref] [PubMed]

Z. Zalevsky, Y. Beiderman, I. Margalit, S. Gingold, M. Teicher, V. Mico, and J. Garcia, “Simultaneous remote extraction of multiple speech sources and heart beats from secondary speckles pattern,” Opt. Express 17(24), 21566–21580 (2009).
[Crossref] [PubMed]

Zhang, H. F.

J.-T. Oh, M.-L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 034032 (2006).
[Crossref] [PubMed]

Zimmer, L.

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

Zink, D.

D. Zink, A. H. Fischer, and J. A. Nickerson, “Nuclear structure in cancer cells,” Nat. Rev. Cancer 4(9), 677–687 (2004).
[Crossref] [PubMed]

Zou, J.

A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, “In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry,” Cancer Res. 72(11), 2738–2745 (2012).
[Crossref] [PubMed]

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, “In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry,” J. Biomed. Opt. 16(2), 020501 (2011).
[Crossref] [PubMed]

Arch. Dermatol. (4)

C. Benvenuto-Andrade, S. W. Dusza, A. L. C. Agero, A. Scope, M. Rajadhyaksha, A. C. Halpern, and A. A. Marghoob, “Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions,” Arch. Dermatol. 143(3), 329–338 (2007).
[Crossref] [PubMed]

Y. Pan, D. S. Gareau, A. Scope, M. Rajadhyaksha, N. A. Mullani, and A. A. Marghoob, “Polarized and nonpolarized dermoscopy: the explanation for the observed differences,” Arch. Dermatol. 144(6), 828–829 (2008).
[Crossref] [PubMed]

A. A. Marghoob, L. Cowell, A. W. Kopf, and A. Scope, “Observation of chrysalis structures with polarized dermoscopy,” Arch. Dermatol. 145(5), 618 (2009).
[Crossref] [PubMed]

R. Satta, L. Fresi, and F. Cottoni, “Dermoscopic rainbow pattern in Kaposi’s sarcoma lesions: our experience,” Arch. Dermatol. 148(10), 1207–1208 (2012).
[Crossref] [PubMed]

Arch. Pathol. Lab. Med. (1)

P. E. Paull, B. J. Hyatt, W. Wassef, and A. H. Fischer, “Confocal laser endomicroscopy: a primer for pathologists,” Arch. Pathol. Lab. Med. 135(10), 1343–1348 (2011).
[Crossref] [PubMed]

Biomed. Mater. Eng. (3)

M. Amouroux, W. C. P. M. Blondel, F. Granel-Brocard, F. Marchal, and F. Guillemin, “A preliminary study on skin phantoms to test spatially resolved-diffuse reflectance spectroscopy as a tool to help diagnose cutaneous melanoma: A non-invasive measurement of Breslow index,” Biomed. Mater. Eng. 18(4-5), 339–343 (2008).
[PubMed]

X. Jia, H. Huang, and R. Wang, “A novel edge detection in medical images by fusing of multi-model from different spatial structure clues,” Biomed. Mater. Eng. 24(1), 1289–1298 (2014).
[PubMed]

C. A. Agudelo and T. Yamaoka, “Magnetic resonance imaging detection of an uncommon granuloma formation after endothelial progenitor cells transplantation,” Biomed. Mater. Eng. 23(6), 555–566 (2013).
[PubMed]

Biomed. Opt. Express (4)

Cancer Res. (1)

A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, “In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry,” Cancer Res. 72(11), 2738–2745 (2012).
[Crossref] [PubMed]

Clin. Cancer Res. (1)

A. L. Clark, A. M. Gillenwater, T. G. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, and R. R. Richards-Kortum, “Confocal microscopy for real-time detection of oral cavity neoplasia,” Clin. Cancer Res. 9(13), 4714–4721 (2003).
[PubMed]

Clin. Dermatol. (1)

Z. Apalla, A. Lallas, G. Argenziano, C. Ricci, S. Piana, E. Moscarella, C. Longo, and I. Zalaudek, “The light and the dark of dermatoscopy in the early diagnosis of melanoma: facts and controversies,” Clin. Dermatol. 31(6), 671–676 (2013).
[Crossref] [PubMed]

Clin. Gastroenterol. Hepatol. (1)

T. D. Wang and J. Van Dam, “Optical biopsy: a new frontier in endoscopic detection and diagnosis,” Clin. Gastroenterol. Hepatol. 2(9), 744–753 (2004).
[Crossref] [PubMed]

Dermatol. Surg. (1)

S. Q. Wang, S. W. Dusza, A. Scope, R. P. Braun, A. W. Kopf, and A. A. Marghoob, “Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study,” Dermatol. Surg. 34(10), 1389–1395 (2008).
[PubMed]

Int. J. Therm. Sci. (1)

M. Pirtini Çetingül and C. Herman, “Quantification of the thermal signature of a melanoma lesion,” Int. J. Therm. Sci. 50(4), 421–431 (2011).
[Crossref]

Invest. Ophthalmol. Vis. Sci. (1)

Z. Zalevsky, I. Margalit, Y. Beiderman, A. Skaat, M. Belkin, R.-P. Tornow, V. Mico, and J. Garcia, “Remote and Continuous Monitoring of Intraocular Pressure Using Novel Photonic Principle,” Invest. Ophthalmol. Vis. Sci. 53(14), 1972 (2012).

J. Am. Acad. Dermatol. (1)

G. Salerni, C. Carrera, L. Lovatto, J. A. Puig-Butille, C. Badenas, E. Plana, S. Puig, and J. Malvehy, “Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma,” J. Am. Acad. Dermatol. 67(1), e17–e27 (2012).
[Crossref] [PubMed]

J. Biomed. Opt. (7)

I. Margalit, Y. Beiderman, A. Skaat, E. Rosenfeld, M. Belkin, R.-P. Tornow, V. Mico, J. Garcia, and Z. Zalevsky, “New method for remote and repeatable monitoring of intraocular pressure variations,” J. Biomed. Opt. 19(2), 027002 (2014).
[Crossref] [PubMed]

A. Garcia-Uribe, E. B. Smith, J. Zou, M. Duvic, V. Prieto, and L. V. Wang, “In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry,” J. Biomed. Opt. 16(2), 020501 (2011).
[Crossref] [PubMed]

A. Safrani, O. Aharon, S. Mor, O. Arnon, L. Rosenberg, and I. Abdulhalim, “Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals,” J. Biomed. Opt. 15(2), 026024 (2010).
[Crossref] [PubMed]

O. Aharon, I. Abdulhalim, O. Arnon, L. Rosenberg, V. Dyomin, and E. Silberstein, “Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging,” J. Biomed. Opt. 16(8), 086008 (2011).
[Crossref] [PubMed]

L. Graham, Y. Yitzhaky, and I. Abdulhalim, “Classification of skin moles from optical spectropolarimetric images: a pilot study,” J. Biomed. Opt. 18(11), 111403 (2013).
[Crossref] [PubMed]

J.-T. Oh, M.-L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 034032 (2006).
[Crossref] [PubMed]

Y. Beiderman, I. Horovitz, N. Burshtein, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern,” J. Biomed. Opt. 15(6), 061707 (2010).
[Crossref] [PubMed]

J. Clin. Oncol. (1)

L. Zimmer, L. E. Haydu, A. M. Menzies, R. A. Scolyer, R. F. Kefford, J. F. Thompson, D. Schadendorf, and G. V. Long, “Reply to M. Perier-Muzet et al,” J. Clin. Oncol. 32(28), 3203–3204 (2014).
[Crossref] [PubMed]

J. Eur. Acad. Dermatol. Venereol. (2)

L. Lovatto, C. Carrera, G. Salerni, L. Alós, J. Malvehy, and S. Puig, “In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up,” J. Eur. Acad. Dermatol. Venereol. 29(10), 1918–1925 (2015).
[Crossref] [PubMed]

A. L. Breton, M. Amini-Adle, G. Duru, N. Poulalhon, S. Dalle, and L. Thomas, “Overview of the use of dermoscopy in academic and non-academic hospital centres in France: a nationwide survey,” J. Eur. Acad. Dermatol. Venereol. 28(9), 1207–1213 (2014).
[Crossref] [PubMed]

JAMA Dermatol. (1)

J. A. Wolf, J. F. Moreau, O. Akilov, T. Patton, J. C. English, J. Ho, and L. K. Ferris, “Diagnostic inaccuracy of smartphone applications for melanoma detection,” JAMA Dermatol. 149(4), 422–426 (2013).
[Crossref] [PubMed]

Mol. Biol. Cell (1)

P. Jorgensen, N. P. Edgington, B. L. Schneider, I. Rupes, M. Tyers, and B. Futcher, “The size of the nucleus increases as yeast cells grow,” Mol. Biol. Cell 18(9), 3523–3532 (2007).
[Crossref] [PubMed]

Nat. Med. (1)

F. O. Nestle, S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf, “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells,” Nat. Med. 4(3), 328–332 (1998).
[Crossref] [PubMed]

Nat. Rev. Cancer (1)

D. Zink, A. H. Fischer, and J. A. Nickerson, “Nuclear structure in cancer cells,” Nat. Rev. Cancer 4(9), 677–687 (2004).
[Crossref] [PubMed]

Nature (1)

J. Y. Lin and D. E. Fisher, “Melanocyte biology and skin pigmentation,” Nature 445(7130), 843–850 (2007).
[Crossref] [PubMed]

Neoplasia (1)

J. G. Fujimoto, C. Pitris, S. A. Boppart, and M. E. Brezinski, “Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy,” Neoplasia 2(1-2), 9–25 (2000).
[Crossref] [PubMed]

Opt. Commun. (2)

Y. Beiderman, M. Teicher, J. Garcia, V. Mico, and Z. Zalevsky, “Optical technique for classification, recognition and identification of obscured objects,” Opt. Commun. 283(21), 4274–4282 (2010).
[Crossref]

A. Shenhav, Z. Brodie, Y. Beiderman, J. Garcia, V. Mico, and Z. Zalevsky, “Optical sensor for remote estimation of alcohol concentration in blood stream,” Opt. Commun. 289, 149–157 (2013).
[Crossref]

Opt. Express (1)

Pharmaceut. Med. (1)

M. Watson, “Drugs in Clinical Development for Melanoma,” Pharmaceut. Med. 26(3), 171–183 (2012).
[Crossref]

Proc. Natl. Acad. Sci. U.S.A. (1)

S. A. Lelièvre, V. M. Weaver, J. A. Nickerson, C. A. Larabell, A. Bhaumik, O. W. Petersen, and M. J. Bissell, “Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus,” Proc. Natl. Acad. Sci. U.S.A. 95(25), 14711–14716 (1998).
[Crossref] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Other (3)

A. H. Sam and J. T. H. Teo, Rapid Medicine (London: Wiley-Blackwell 2010)

American Cancer Society (ACS), http://www.cancer.org/cancer/skincancer/melanoma

J. Zhao, H. Zeng, D. McLean, S. Kalia, and H. Lui, “Recent Advances in Real-Time Raman Spectroscopy for In Vivo Skin Cancer Diagnosis,” Optics in the Life Sciences, BT4A.6 (2015).

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (14)

Fig. 1
Fig. 1 The temporal change in the position of the correlation peak (in pixels) versus time.
Fig. 2
Fig. 2 A flowchart of the pigmentary lesion effects on the speckle pattern vibrations.
Fig. 3
Fig. 3 Schematic diagram of the system.
Fig. 4
Fig. 4 (a) Frequency response of a pigmentary lesion. (b) Frequency response of skin area without any pigmentary lesion. The excitation frequency during this experiment is 170 Hz.
Fig. 5
Fig. 5 (a) The optical configuration for remote measuring of pigmentary lesion. (b) Reference spot of normal skin is positioned under a laser illumination. (c) Demonstration of a pigmentary lesion under illumination.
Fig. 6
Fig. 6 Stability test of the system: The normalized optical parameter versus 10 different samples taken while a normal spot of the skin is under illumination. The STD is displayed.
Fig. 7
Fig. 7 The time domain response to the series of different vibration frequencies applied by the CVS.
Fig. 8
Fig. 8 Different temporal vibrations of the skin while frequency of (a) 55 Hz (b) 100 Hz (c) 145 Hz (d) 190 Hz (e) 235 Hz was applied by the CVS.
Fig. 9
Fig. 9 Different frequency responses of the skin while frequency of (a) 55 Hz (b) 100 Hz (c) 145 Hz (d) 190 Hz (e) 235 Hz was applied by the CVS.
Fig. 10
Fig. 10 The frequency response signature of a normal skin.
Fig. 11
Fig. 11 Nine different optical signatures of different skin spots with respect to a pigmented lesion spot. The optical measurement of the pigmented lesion is denoted with a red line and the optical measurement of the normal skin is denoted with a blue dashed line.
Fig. 12
Fig. 12 The signature deviation of the pigmented lesion optical measurement with respect to nine different optical measurements of normal skin. The optical measurement of the pigmented lesion is denoted with a red dashed line.
Fig. 13
Fig. 13 Six different signatures of skin tissues.
Fig. 14
Fig. 14 The average frequency responses of 20 different small pigmented lesions with respect to reference spots after calibration. The responses are measured at frequencies of 170Hz and 210Hz.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

β= 4πtanα λ 4πα λ
X(k)= j=1 N x(j) e 2πijk/N
s= ( 1 N1 n=1 N ( x n x ¯ ) 2 ) 0.5

Metrics