Abstract

We quantified molecular specificity of Cy5.5-GX1 in vivo with dynamic fluorescence imaging to better understand its kinetic properties. According to whether or not free GX1 was injected and when it was injected, twelve of BGC-823 xenografted mice were randomly divided into three groups and underwent a 60 minute dynamic fluorescence scanning. Combined with a principal-component analysis, the binding potential (Bp) of the probe was determined by both Logan graphical analysis with reference tissue model (GARTM) and Lammertsma simplified reference tissue model (SRTM). The sum of the pharmacokinetic rate constants (SKRC) was quantified by the Gurfinkel exponential model (GEXPM). Cy5.5-GX1 specifically targeted tumor both in vitro and in vivo. We obtained similar quantification results of Bp (GARTM Bp = 0.582 ± 0.2655, SRTM Bp = 0.618 ± 0.2923), and obtained a good linear relation between the Bp value and the SKRC value. Our results indicate that the SKRC value is more suitable for an early-stage kinetic data analysis, and the Bp value depicts kinetic characteristics under the equilibrium state. Dynamic fluorescence imaging in conjunction with various kinetic models are optimal tools to quantify molecular specificity of the Cy5.5-GX1 probe in vivo.

© 2016 Optical Society of America

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2015 (1)

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

2014 (1)

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

2013 (3)

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
[Crossref] [PubMed]

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
[Crossref] [PubMed]

2012 (5)

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

K. Chen, L. P. Yap, R. Park, X. Hui, K. Wu, D. Fan, X. Chen, and P. S. Conti, “A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice,” Amino Acids 42(4), 1329–1337 (2012).
[Crossref] [PubMed]

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
[Crossref] [PubMed]

2011 (1)

S. Luo, E. Zhang, Y. Su, T. Cheng, and C. Shi, “A review of NIR dyes in cancer targeting and imaging,” Biomaterials 32(29), 7127–7138 (2011).
[Crossref] [PubMed]

2010 (2)

R. Strippoli, I. Benedicto, M. Foronda, M. L. Perez-Lozano, S. Sánchez-Perales, M. López-Cabrera, and M. Á. Del Pozo, “p38 maintains E-cadherin expression by modulating TAK1-NF-κ B during epithelial-to-mesenchymal transition,” J. Cell Sci. 123(24), 4321–4331 (2010).
[Crossref] [PubMed]

V. Chernomordik, M. Hassan, S. B. Lee, R. Zielinski, A. Gandjbakhche, and J. Capala, “Quantitative analysis of HER2 receptor expression in vivo by NIR optical imaging,” Mol. Imaging 9(4), 192–200 (2010).
[PubMed]

2009 (4)

G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
[Crossref] [PubMed]

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

K. I. Shoghi, “Quantitative small animal PET,” Q. J. Nucl. Med. Mol. Imaging 53(4), 365–373 (2009).
[PubMed]

2008 (2)

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

W. Cai and X. Chen, “Multimodality molecular imaging of tumor angiogenesis,” J. Nucl. Med. 49(Suppl 2), 113S–128S (2008).
[Crossref] [PubMed]

2007 (2)

E. M. Hillman and A. Moore, “All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast,” Nat. Photonics 1(9), 526–530 (2007).
[Crossref] [PubMed]

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

2006 (1)

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

2005 (3)

S. Kwon, S. Ke, J. P. Houston, W. Wang, Q. Wu, C. Li, and E. M. Sevick-Muraca, “Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi’s sarcoma,” Mol. Imaging 4(2), 75–87 (2005).
[PubMed]

K. Shah and R. Weissleder, “Molecular optical imaging: applications leading to the development of present day therapeutics,” NeuroRx 2(2), 215–225 (2005).
[Crossref] [PubMed]

M. Gurfinkel, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quantifying molecular specificity of alphavbeta3 integrin-targeted optical contrast agents with dynamic optical imaging,” J. Biomed. Opt. 10(3), 034019 (2005).
[Crossref] [PubMed]

2004 (2)

M. Gurfinkel, S. Ke, X. Wen, C. Li, and E. M. Sevick-Muraca, “Near-infrared fluorescence optical imaging and tomography,” Dis. Markers 19(2-3), 107–121 (2004).
[Crossref] [PubMed]

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

2003 (1)

J. Logan, “A review of graphical methods for tracer studies and strategies to reduce bias,” Nucl. Med. Biol. 30(8), 833–844 (2003).
[Crossref] [PubMed]

2001 (1)

M. Ichise, J. H. Meyer, and Y. Yonekura, “An introduction to PET and SPECT neuroreceptor quantification models,” J. Nucl. Med. 42(5), 755–763 (2001).
[PubMed]

1996 (2)

A. A. Lammertsma and S. P. Hume, “Simplified reference tissue model for PET receptor studies,” Neuroimage 4(3), 153–158 (1996).
[Crossref] [PubMed]

J. Logan, J. S. Fowler, N. D. Volkow, G. J. Wang, Y. S. Ding, and D. L. Alexoff, “Distribution volume ratios without blood sampling from graphical analysis of PET data,” J. Cereb. Blood Flow Metab. 16(5), 834–840 (1996).
[Crossref] [PubMed]

Alexoff, D. L.

J. Logan, J. S. Fowler, N. D. Volkow, G. J. Wang, Y. S. Ding, and D. L. Alexoff, “Distribution volume ratios without blood sampling from graphical analysis of PET data,” J. Cereb. Blood Flow Metab. 16(5), 834–840 (1996).
[Crossref] [PubMed]

Armijo, A.

G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
[Crossref] [PubMed]

Benedicto, I.

R. Strippoli, I. Benedicto, M. Foronda, M. L. Perez-Lozano, S. Sánchez-Perales, M. López-Cabrera, and M. Á. Del Pozo, “p38 maintains E-cadherin expression by modulating TAK1-NF-κ B during epithelial-to-mesenchymal transition,” J. Cell Sci. 123(24), 4321–4331 (2010).
[Crossref] [PubMed]

Cai, W.

W. Cai and X. Chen, “Multimodality molecular imaging of tumor angiogenesis,” J. Nucl. Med. 49(Suppl 2), 113S–128S (2008).
[Crossref] [PubMed]

Cao, S.

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Capala, J.

V. Chernomordik, M. Hassan, S. B. Lee, R. Zielinski, A. Gandjbakhche, and J. Capala, “Quantitative analysis of HER2 receptor expression in vivo by NIR optical imaging,” Mol. Imaging 9(4), 192–200 (2010).
[PubMed]

Carson, R. E.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Chai, N.

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Chen, B.

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Chen, K.

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

K. Chen, L. P. Yap, R. Park, X. Hui, K. Wu, D. Fan, X. Chen, and P. S. Conti, “A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice,” Amino Acids 42(4), 1329–1337 (2012).
[Crossref] [PubMed]

Chen, X.

K. Chen, L. P. Yap, R. Park, X. Hui, K. Wu, D. Fan, X. Chen, and P. S. Conti, “A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice,” Amino Acids 42(4), 1329–1337 (2012).
[Crossref] [PubMed]

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
[Crossref] [PubMed]

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

W. Cai and X. Chen, “Multimodality molecular imaging of tumor angiogenesis,” J. Nucl. Med. 49(Suppl 2), 113S–128S (2008).
[Crossref] [PubMed]

Cheng, T.

S. Luo, E. Zhang, Y. Su, T. Cheng, and C. Shi, “A review of NIR dyes in cancer targeting and imaging,” Biomaterials 32(29), 7127–7138 (2011).
[Crossref] [PubMed]

Chernomordik, V.

V. Chernomordik, M. Hassan, S. B. Lee, R. Zielinski, A. Gandjbakhche, and J. Capala, “Quantitative analysis of HER2 receptor expression in vivo by NIR optical imaging,” Mol. Imaging 9(4), 192–200 (2010).
[PubMed]

Choi, H. S.

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

Conti, P. S.

K. Chen, L. P. Yap, R. Park, X. Hui, K. Wu, D. Fan, X. Chen, and P. S. Conti, “A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice,” Amino Acids 42(4), 1329–1337 (2012).
[Crossref] [PubMed]

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

Cunningham, V. J.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Dang, D.

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Davis, S. C.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
[Crossref] [PubMed]

Deharvengt, S. J.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
[Crossref] [PubMed]

Del Pozo, M. Á.

R. Strippoli, I. Benedicto, M. Foronda, M. L. Perez-Lozano, S. Sánchez-Perales, M. López-Cabrera, and M. Á. Del Pozo, “p38 maintains E-cadherin expression by modulating TAK1-NF-κ B during epithelial-to-mesenchymal transition,” J. Cell Sci. 123(24), 4321–4331 (2010).
[Crossref] [PubMed]

Delforge, J.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Deng, T. Z.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Ding, J.

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Ding, Y. S.

J. Logan, J. S. Fowler, N. D. Volkow, G. J. Wang, Y. S. Ding, and D. L. Alexoff, “Distribution volume ratios without blood sampling from graphical analysis of PET data,” J. Cereb. Blood Flow Metab. 16(5), 834–840 (1996).
[Crossref] [PubMed]

Dong, L.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Du, W.

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

Dumont, R. A.

G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
[Crossref] [PubMed]

Elliott, J. T.

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

Fan, D.

K. Chen, L. P. Yap, R. Park, X. Hui, K. Wu, D. Fan, X. Chen, and P. S. Conti, “A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice,” Amino Acids 42(4), 1329–1337 (2012).
[Crossref] [PubMed]

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Fan, D. M.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Ferl, G. Z.

G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
[Crossref] [PubMed]

Foronda, M.

R. Strippoli, I. Benedicto, M. Foronda, M. L. Perez-Lozano, S. Sánchez-Perales, M. López-Cabrera, and M. Á. Del Pozo, “p38 maintains E-cadherin expression by modulating TAK1-NF-κ B during epithelial-to-mesenchymal transition,” J. Cell Sci. 123(24), 4321–4331 (2010).
[Crossref] [PubMed]

Fowler, J. S.

J. Logan, J. S. Fowler, N. D. Volkow, G. J. Wang, Y. S. Ding, and D. L. Alexoff, “Distribution volume ratios without blood sampling from graphical analysis of PET data,” J. Cereb. Blood Flow Metab. 16(5), 834–840 (1996).
[Crossref] [PubMed]

Fujita, M.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Gandjbakhche, A.

V. Chernomordik, M. Hassan, S. B. Lee, R. Zielinski, A. Gandjbakhche, and J. Capala, “Quantitative analysis of HER2 receptor expression in vivo by NIR optical imaging,” Mol. Imaging 9(4), 192–200 (2010).
[PubMed]

Gao, H.

N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
[Crossref] [PubMed]

Gjedde, A.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Gunn, J. R.

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
[Crossref] [PubMed]

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

Gunn, R. N.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Guo, C.

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Guo, N.

N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
[Crossref] [PubMed]

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

Gurfinkel, M.

M. Gurfinkel, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quantifying molecular specificity of alphavbeta3 integrin-targeted optical contrast agents with dynamic optical imaging,” J. Biomed. Opt. 10(3), 034019 (2005).
[Crossref] [PubMed]

M. Gurfinkel, S. Ke, X. Wen, C. Li, and E. M. Sevick-Muraca, “Near-infrared fluorescence optical imaging and tomography,” Dis. Markers 19(2-3), 107–121 (2004).
[Crossref] [PubMed]

Hamzei, N.

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

Han, Y.

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Hao, Z. M.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Hasan, T.

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
[Crossref] [PubMed]

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

Hassan, M.

V. Chernomordik, M. Hassan, S. B. Lee, R. Zielinski, A. Gandjbakhche, and J. Capala, “Quantitative analysis of HER2 receptor expression in vivo by NIR optical imaging,” Mol. Imaging 9(4), 192–200 (2010).
[PubMed]

Haubner, R.

G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
[Crossref] [PubMed]

He, L.

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

He, M.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

Hextrum, S. K.

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

Hildebrandt, I. J.

G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
[Crossref] [PubMed]

Hillman, E. M.

E. M. Hillman and A. Moore, “All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast,” Nat. Photonics 1(9), 526–530 (2007).
[Crossref] [PubMed]

Holden, J.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Holt, R. W.

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

Hong, L.

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Houle, S.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Houston, J. P.

S. Kwon, S. Ke, J. P. Houston, W. Wang, Q. Wu, C. Li, and E. M. Sevick-Muraca, “Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi’s sarcoma,” Mol. Imaging 4(2), 75–87 (2005).
[PubMed]

Hu, H.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
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Huang, S. C.

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Hui, X.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
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K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
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B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
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X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Hume, S. P.

A. A. Lammertsma and S. P. Hume, “Simplified reference tissue model for PET receptor studies,” Neuroimage 4(3), 153–158 (1996).
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Ichise, M.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
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M. Ichise, J. H. Meyer, and Y. Yonekura, “An introduction to PET and SPECT neuroreceptor quantification models,” J. Nucl. Med. 42(5), 755–763 (2001).
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R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
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Innis, R. B.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
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Ito, H.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
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Jacboson, O.

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
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Jeong, J. M.

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

Jin, B.

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Jin, H.

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
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Ke, S.

M. Gurfinkel, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quantifying molecular specificity of alphavbeta3 integrin-targeted optical contrast agents with dynamic optical imaging,” J. Biomed. Opt. 10(3), 034019 (2005).
[Crossref] [PubMed]

S. Kwon, S. Ke, J. P. Houston, W. Wang, Q. Wu, C. Li, and E. M. Sevick-Muraca, “Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi’s sarcoma,” Mol. Imaging 4(2), 75–87 (2005).
[PubMed]

M. Gurfinkel, S. Ke, X. Wen, C. Li, and E. M. Sevick-Muraca, “Near-infrared fluorescence optical imaging and tomography,” Dis. Markers 19(2-3), 107–121 (2004).
[Crossref] [PubMed]

Kiesewetter, D. O.

N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
[Crossref] [PubMed]

Kim, J. H.

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

Kim, Y. H.

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

Kim, Y. J.

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

Kimura, Y.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Klubben, W. S.

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
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Knudsen, G. M.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Knuuti, J.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Koeppe, R. A.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Kwon, S.

S. Kwon, S. Ke, J. P. Houston, W. Wang, Q. Wu, C. Li, and E. M. Sevick-Muraca, “Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi’s sarcoma,” Mol. Imaging 4(2), 75–87 (2005).
[PubMed]

Lammertsma, A. A.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

A. A. Lammertsma and S. P. Hume, “Simplified reference tissue model for PET receptor studies,” Neuroimage 4(3), 153–158 (1996).
[Crossref] [PubMed]

Lang, L.

N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
[Crossref] [PubMed]

Laruelle, M.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Lee, D. S.

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

Lee, J. S.

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

Lee, S.

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

Lee, S. B.

V. Chernomordik, M. Hassan, S. B. Lee, R. Zielinski, A. Gandjbakhche, and J. Capala, “Quantitative analysis of HER2 receptor expression in vivo by NIR optical imaging,” Mol. Imaging 9(4), 192–200 (2010).
[PubMed]

Li, C.

S. Kwon, S. Ke, J. P. Houston, W. Wang, Q. Wu, C. Li, and E. M. Sevick-Muraca, “Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi’s sarcoma,” Mol. Imaging 4(2), 75–87 (2005).
[PubMed]

M. Gurfinkel, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quantifying molecular specificity of alphavbeta3 integrin-targeted optical contrast agents with dynamic optical imaging,” J. Biomed. Opt. 10(3), 034019 (2005).
[Crossref] [PubMed]

M. Gurfinkel, S. Ke, X. Wen, C. Li, and E. M. Sevick-Muraca, “Near-infrared fluorescence optical imaging and tomography,” Dis. Markers 19(2-3), 107–121 (2004).
[Crossref] [PubMed]

Li, M.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

Li, Q.

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

Li, W.

N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
[Crossref] [PubMed]

Li, X.

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

Liang, J.

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
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Liang, S.

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
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Liang, S. H.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
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Lin, T.

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
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Liu, J.

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Liu, Y.

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

Liu, Z.

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Logan, J.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

J. Logan, “A review of graphical methods for tracer studies and strategies to reduce bias,” Nucl. Med. Biol. 30(8), 833–844 (2003).
[Crossref] [PubMed]

J. Logan, J. S. Fowler, N. D. Volkow, G. J. Wang, Y. S. Ding, and D. L. Alexoff, “Distribution volume ratios without blood sampling from graphical analysis of PET data,” J. Cereb. Blood Flow Metab. 16(5), 834–840 (1996).
[Crossref] [PubMed]

López-Cabrera, M.

R. Strippoli, I. Benedicto, M. Foronda, M. L. Perez-Lozano, S. Sánchez-Perales, M. López-Cabrera, and M. Á. Del Pozo, “p38 maintains E-cadherin expression by modulating TAK1-NF-κ B during epithelial-to-mesenchymal transition,” J. Cell Sci. 123(24), 4321–4331 (2010).
[Crossref] [PubMed]

Luo, S.

S. Luo, E. Zhang, Y. Su, T. Cheng, and C. Shi, “A review of NIR dyes in cancer targeting and imaging,” Biomaterials 32(29), 7127–7138 (2011).
[Crossref] [PubMed]

Ma, Y.

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

Maguire, R. P.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Mansfield, J. R.

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

Meyer, J. H.

M. Ichise, J. H. Meyer, and Y. Yonekura, “An introduction to PET and SPECT neuroreceptor quantification models,” J. Nucl. Med. 42(5), 755–763 (2001).
[PubMed]

Mintun, M. A.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
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Moore, A.

E. M. Hillman and A. Moore, “All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast,” Nat. Photonics 1(9), 526–530 (2007).
[Crossref] [PubMed]

Morris, E. D.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Nie, Y.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
[Crossref] [PubMed]

Niu, G.

L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
[Crossref] [PubMed]

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

Pan, Y.

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Park, R.

K. Chen, L. P. Yap, R. Park, X. Hui, K. Wu, D. Fan, X. Chen, and P. S. Conti, “A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice,” Amino Acids 42(4), 1329–1337 (2012).
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Parsey, R.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Perez-Lozano, M. L.

R. Strippoli, I. Benedicto, M. Foronda, M. L. Perez-Lozano, S. Sánchez-Perales, M. López-Cabrera, and M. Á. Del Pozo, “p38 maintains E-cadherin expression by modulating TAK1-NF-κ B during epithelial-to-mesenchymal transition,” J. Cell Sci. 123(24), 4321–4331 (2010).
[Crossref] [PubMed]

Pogue, B. W.

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
[Crossref] [PubMed]

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

Price, J. C.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Qiao, T. D.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Reischl, G.

G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
[Crossref] [PubMed]

Samkoe, K. S.

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
[Crossref] [PubMed]

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

Sánchez-Perales, S.

R. Strippoli, I. Benedicto, M. Foronda, M. L. Perez-Lozano, S. Sánchez-Perales, M. López-Cabrera, and M. Á. Del Pozo, “p38 maintains E-cadherin expression by modulating TAK1-NF-κ B during epithelial-to-mesenchymal transition,” J. Cell Sci. 123(24), 4321–4331 (2010).
[Crossref] [PubMed]

Sevick-Muraca, E. M.

S. Kwon, S. Ke, J. P. Houston, W. Wang, Q. Wu, C. Li, and E. M. Sevick-Muraca, “Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi’s sarcoma,” Mol. Imaging 4(2), 75–87 (2005).
[PubMed]

M. Gurfinkel, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quantifying molecular specificity of alphavbeta3 integrin-targeted optical contrast agents with dynamic optical imaging,” J. Biomed. Opt. 10(3), 034019 (2005).
[Crossref] [PubMed]

M. Gurfinkel, S. Ke, X. Wen, C. Li, and E. M. Sevick-Muraca, “Near-infrared fluorescence optical imaging and tomography,” Dis. Markers 19(2-3), 107–121 (2004).
[Crossref] [PubMed]

Sexton, K. J.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
[Crossref] [PubMed]

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

Shah, K.

K. Shah and R. Weissleder, “Molecular optical imaging: applications leading to the development of present day therapeutics,” NeuroRx 2(2), 215–225 (2005).
[Crossref] [PubMed]

Shi, C.

S. Luo, E. Zhang, Y. Su, T. Cheng, and C. Shi, “A review of NIR dyes in cancer targeting and imaging,” Biomaterials 32(29), 7127–7138 (2011).
[Crossref] [PubMed]

Shi, Y.

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Shoghi, K. I.

K. I. Shoghi, “Quantitative small animal PET,” Q. J. Nucl. Med. Mol. Imaging 53(4), 365–373 (2009).
[PubMed]

Slifstein, M.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Sossi, V.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Strippoli, R.

R. Strippoli, I. Benedicto, M. Foronda, M. L. Perez-Lozano, S. Sánchez-Perales, M. López-Cabrera, and M. Á. Del Pozo, “p38 maintains E-cadherin expression by modulating TAK1-NF-κ B during epithelial-to-mesenchymal transition,” J. Cell Sci. 123(24), 4321–4331 (2010).
[Crossref] [PubMed]

Su, H.

G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
[Crossref] [PubMed]

Su, Y.

S. Luo, E. Zhang, Y. Su, T. Cheng, and C. Shi, “A review of NIR dyes in cancer targeting and imaging,” Biomaterials 32(29), 7127–7138 (2011).
[Crossref] [PubMed]

Suhara, T.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Sun, L.

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Sun, X.

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

Tian, J.

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
[Crossref] [PubMed]

Tichauer, K. M.

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
[Crossref] [PubMed]

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

Volkow, N. D.

J. Logan, J. S. Fowler, N. D. Volkow, G. J. Wang, Y. S. Ding, and D. L. Alexoff, “Distribution volume ratios without blood sampling from graphical analysis of PET data,” J. Cereb. Blood Flow Metab. 16(5), 834–840 (1996).
[Crossref] [PubMed]

Votaw, J. R.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Wan, Y.

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

Wang, G. J.

J. Logan, J. S. Fowler, N. D. Volkow, G. J. Wang, Y. S. Ding, and D. L. Alexoff, “Distribution volume ratios without blood sampling from graphical analysis of PET data,” J. Cereb. Blood Flow Metab. 16(5), 834–840 (1996).
[Crossref] [PubMed]

Wang, J.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Wang, L.

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

Wang, W.

M. Gurfinkel, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quantifying molecular specificity of alphavbeta3 integrin-targeted optical contrast agents with dynamic optical imaging,” J. Biomed. Opt. 10(3), 034019 (2005).
[Crossref] [PubMed]

S. Kwon, S. Ke, J. P. Houston, W. Wang, Q. Wu, C. Li, and E. M. Sevick-Muraca, “Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi’s sarcoma,” Mol. Imaging 4(2), 75–87 (2005).
[PubMed]

Wang, X.

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

Wang, Y.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Weber, W. A.

G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
[Crossref] [PubMed]

Weissleder, R.

K. Shah and R. Weissleder, “Molecular optical imaging: applications leading to the development of present day therapeutics,” NeuroRx 2(2), 215–225 (2005).
[Crossref] [PubMed]

Wen, X.

M. Gurfinkel, S. Ke, X. Wen, C. Li, and E. M. Sevick-Muraca, “Near-infrared fluorescence optical imaging and tomography,” Dis. Markers 19(2-3), 107–121 (2004).
[Crossref] [PubMed]

Wong, D. F.

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
[Crossref] [PubMed]

Wu, K.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
[Crossref] [PubMed]

K. Chen, L. P. Yap, R. Park, X. Hui, K. Wu, D. Fan, X. Chen, and P. S. Conti, “A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice,” Amino Acids 42(4), 1329–1337 (2012).
[Crossref] [PubMed]

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Wu, K. C.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Wu, Q.

S. Kwon, S. Ke, J. P. Houston, W. Wang, Q. Wu, C. Li, and E. M. Sevick-Muraca, “Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi’s sarcoma,” Mol. Imaging 4(2), 75–87 (2005).
[PubMed]

Xia, L.

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
[Crossref] [PubMed]

Xie, Q.

N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
[Crossref] [PubMed]

Xin, B.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

Xin, J.

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
[Crossref] [PubMed]

Xu, X.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Yan, K.

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Yang, B. Y.

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

Yang, H. H.

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

Yao, L.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Yap, L. P.

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

K. Chen, L. P. Yap, R. Park, X. Hui, K. Wu, D. Fan, X. Chen, and P. S. Conti, “A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice,” Amino Acids 42(4), 1329–1337 (2012).
[Crossref] [PubMed]

Yin, J.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
[Crossref] [PubMed]

Yonekura, Y.

M. Ichise, J. H. Meyer, and Y. Yonekura, “An introduction to PET and SPECT neuroreceptor quantification models,” J. Nucl. Med. 42(5), 755–763 (2001).
[PubMed]

Youn, H.

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

Zhang, E.

S. Luo, E. Zhang, Y. Su, T. Cheng, and C. Shi, “A review of NIR dyes in cancer targeting and imaging,” Biomaterials 32(29), 7127–7138 (2011).
[Crossref] [PubMed]

Zhang, J.

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
[Crossref] [PubMed]

Zhang, X.

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
[Crossref] [PubMed]

Zhang, Y.

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
[Crossref] [PubMed]

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

Zhao, L.

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
[Crossref] [PubMed]

Zhao, P.

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

Zhao, P. T.

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

Zhi, M.

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
[Crossref] [PubMed]

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
[Crossref] [PubMed]

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L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

Zielinski, R.

V. Chernomordik, M. Hassan, S. B. Lee, R. Zielinski, A. Gandjbakhche, and J. Capala, “Quantitative analysis of HER2 receptor expression in vivo by NIR optical imaging,” Mol. Imaging 9(4), 192–200 (2010).
[PubMed]

Amino Acids (1)

K. Chen, L. P. Yap, R. Park, X. Hui, K. Wu, D. Fan, X. Chen, and P. S. Conti, “A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice,” Amino Acids 42(4), 1329–1337 (2012).
[Crossref] [PubMed]

Angiogenesis (1)

J. H. Kim, Y. H. Kim, Y. J. Kim, B. Y. Yang, J. M. Jeong, H. Youn, D. S. Lee, and J. S. Lee, “Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK),” Angiogenesis 16(4), 837–846 (2013).
[Crossref] [PubMed]

Austin J. Biomed. Eng. (1)

N. Hamzei, K. S. Samkoe, J. T. Elliott, R. W. Holt, J. R. Gunn, T. Hasan, B. W. Pogue, and K. M. Tichauer, “Comparison of kinetic models for dual-tracer receptor concentration imaging in tumors,” Austin J. Biomed. Eng. 1(1), 9 (2014).
[PubMed]

Bioconjug. Chem. (1)

J. Xin, X. Zhang, J. Liang, L. Xia, J. Yin, Y. Nie, K. Wu, and J. Tian, “In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes,” Bioconjug. Chem. 24(7), 1134–1143 (2013).
[Crossref] [PubMed]

Biomaterials (1)

S. Luo, E. Zhang, Y. Su, T. Cheng, and C. Shi, “A review of NIR dyes in cancer targeting and imaging,” Biomaterials 32(29), 7127–7138 (2011).
[Crossref] [PubMed]

BMC Cell Biol. (1)

B. Chen, S. Cao, Y. Zhang, X. Wang, J. Liu, X. Hui, Y. Wan, W. Du, L. Wang, K. Wu, and D. Fan, “A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy,” BMC Cell Biol. 10(1), 63 (2009).
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Cancer Biol. Ther. (1)

M. Zhi, K. C. Wu, L. Dong, Z. M. Hao, T. Z. Deng, L. Hong, S. H. Liang, P. T. Zhao, T. D. Qiao, Y. Wang, X. Xu, and D. M. Fan, “Characterization of a specific phage-displayed Peptide binding to vasculature of human gastric cancer,” Cancer Biol. Ther. 3(12), 1232–1235 (2004).
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Dis. Markers (1)

M. Gurfinkel, S. Ke, X. Wen, C. Li, and E. M. Sevick-Muraca, “Near-infrared fluorescence optical imaging and tomography,” Dis. Markers 19(2-3), 107–121 (2004).
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M. Gurfinkel, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quantifying molecular specificity of alphavbeta3 integrin-targeted optical contrast agents with dynamic optical imaging,” J. Biomed. Opt. 10(3), 034019 (2005).
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R. Strippoli, I. Benedicto, M. Foronda, M. L. Perez-Lozano, S. Sánchez-Perales, M. López-Cabrera, and M. Á. Del Pozo, “p38 maintains E-cadherin expression by modulating TAK1-NF-κ B during epithelial-to-mesenchymal transition,” J. Cell Sci. 123(24), 4321–4331 (2010).
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J. Cereb. Blood Flow Metab. (2)

R. B. Innis, V. J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R. N. Gunn, J. Holden, S. Houle, S. C. Huang, M. Ichise, H. Iida, H. Ito, Y. Kimura, R. A. Koeppe, G. M. Knudsen, J. Knuuti, A. A. Lammertsma, M. Laruelle, J. Logan, R. P. Maguire, M. A. Mintun, E. D. Morris, R. Parsey, J. C. Price, M. Slifstein, V. Sossi, T. Suhara, J. R. Votaw, D. F. Wong, and R. E. Carson, “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” J. Cereb. Blood Flow Metab. 27(9), 1533–1539 (2007).
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J. Logan, J. S. Fowler, N. D. Volkow, G. J. Wang, Y. S. Ding, and D. L. Alexoff, “Distribution volume ratios without blood sampling from graphical analysis of PET data,” J. Cereb. Blood Flow Metab. 16(5), 834–840 (1996).
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X. Hui, Y. Han, S. Liang, Z. Liu, J. Liu, L. Hong, L. Zhao, L. He, S. Cao, B. Chen, K. Yan, B. Jin, N. Chai, J. Wang, K. Wu, and D. Fan, “Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC,” J. Control. Release 131(2), 86–93 (2008).
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J. Mol. Med. (1)

S. Liang, T. Lin, J. Ding, Y. Pan, D. Dang, C. Guo, M. Zhi, P. Zhao, L. Sun, L. Hong, Y. Shi, L. Yao, J. Liu, K. Wu, and D. Fan, “Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer,” J. Mol. Med. 84(9), 764–773 (2006).
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J. Nucl. Med. (3)

M. Ichise, J. H. Meyer, and Y. Yonekura, “An introduction to PET and SPECT neuroreceptor quantification models,” J. Nucl. Med. 42(5), 755–763 (2001).
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G. Z. Ferl, R. A. Dumont, I. J. Hildebrandt, A. Armijo, R. Haubner, G. Reischl, H. Su, W. A. Weber, and S. C. Huang, “Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice,” J. Nucl. Med. 50(2), 250–258 (2009).
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Mol. Biotechnol. (1)

S. Cao, Y. Liu, X. Li, Y. Zhang, J. Wang, W. Du, Y. Han, H. Jin, L. Zhao, K. Wu, and D. Fan, “Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha,” Mol. Biotechnol. 43(1), 1–7 (2009).
[Crossref] [PubMed]

Mol. Imaging (2)

S. Kwon, S. Ke, J. P. Houston, W. Wang, Q. Wu, C. Li, and E. M. Sevick-Muraca, “Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi’s sarcoma,” Mol. Imaging 4(2), 75–87 (2005).
[PubMed]

V. Chernomordik, M. Hassan, S. B. Lee, R. Zielinski, A. Gandjbakhche, and J. Capala, “Quantitative analysis of HER2 receptor expression in vivo by NIR optical imaging,” Mol. Imaging 9(4), 192–200 (2010).
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Mol. Imaging Biol. (3)

K. M. Tichauer, K. S. Samkoe, K. J. Sexton, S. K. Hextrum, H. H. Yang, W. S. Klubben, J. R. Gunn, T. Hasan, and B. W. Pogue, “In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging,” Mol. Imaging Biol. 14(5), 584–592 (2012).
[Crossref] [PubMed]

K. Chen, X. Sun, G. Niu, Y. Ma, L. P. Yap, X. Hui, K. Wu, D. Fan, P. S. Conti, and X. Chen, “Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature,” Mol. Imaging Biol. 14(1), 96–105 (2012).
[Crossref] [PubMed]

J. Yin, X. Hui, L. Yao, M. Li, H. Hu, J. Zhang, B. Xin, M. He, J. Wang, Y. Nie, and K. Wu, “Evaluation of Tc-99 m Labeled Dimeric GX1 Peptides for Imaging of Colorectal Cancer Vasculature,” Mol. Imaging Biol. 17(5), 661–670 (2015).
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N. Guo, L. Lang, W. Li, D. O. Kiesewetter, H. Gao, G. Niu, Q. Xie, and X. Chen, “Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model,” PLoS One 7(5), e37506 (2012).
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S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Natl. Acad. Sci. U.S.A. 110(22), 9025–9030 (2013).
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L. Zhu, N. Guo, Q. Li, Y. Ma, O. Jacboson, S. Lee, H. S. Choi, J. R. Mansfield, G. Niu, and X. Chen, “Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe,” Theranostics 2(8), 746–756 (2012).
[Crossref] [PubMed]

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Figures (7)

Fig. 1
Fig. 1 A. A diagrammatic sketch of pharmacokinetic models for GARTM and SRTM. CP, CND and CS represent probe concentrations in the corresponding compartment in tumor or muscle regions. K1 [ml/g/min], k2 [1/min], k3 [1/min] and k4 [1/min] are the transporting and binding rates of the tracer for the corresponding compartment in tumor or muscle regions. B. A schematic diagram of the pharmacokinetic model for the GEXPM. The definition of CP, CND and CS is consistent with the above definition. Kel [ml/g/min], K1 [ml/g/min], k2 [1/min] and kr [1/min] are the transport and binding rates of the tracer for the corresponding compartment in the tumor region.
Fig. 2
Fig. 2 Confocal immunofluorescent images of Cy5.5-GX1 expression and localization in Co-HUVECs, HUVECs, GES and BGC-823 cells (400 ×). Cells were stained with DAPI (nuclear staining) colored in green, and Cy5.5-GX1 colored in red.
Fig. 3
Fig. 3 Representative original fluorescent images (no background subtraction) at different time points generated from 1 hour dynamic optical imaging and 24 hours after administration of (A) non-block group, (B) 1h-block group, and (C) 24h-block group. White arrows indicate tumor locations, and all fluorescent images generated from 24 hours after probe injection (the third columns) are displayed on the same linear color scale to allow for qualitative comparison. D-F. Corresponding time activity curves of tumor and muscle regions.
Fig. 4
Fig. 4 A. Representative white light image showing the ROI locations; ROI-1 refers to tumor ROI, ROI-2 refers to muscle ROI, and ROI-3 is background ROI. Pure time activity curves in tumor and muscle regions recovered by the SVD analysis from raw fluorescent dynamic images corresponding to the (B) non-block group, (C) 1h-block group and (D) 24h-block group.
Fig. 5
Fig. 5 A. Representative results of GARTM fitted to 60 min dynamic optical data with the SVD analysis, which showed good linearity of normalized integrated (Int) tumor activity vs. normalized integrated muscle tissue activity. Slopes of fitted lines refer to DVRs and Bp = DVR-1. The definition of the x-axis and y-axis as described above. B. Representative results of SRTM fitted to 60 min dynamic optical data with the SVD analysis. The red triangles represent the original experimental data from animals receiving the Cy5.5-GX1 alone, while the blue dots and green squares represent the original experimental data acquired from an animal receiving Cy5.5-GX1 1 hour and 24 hours, respectively, after the administration of the GX1 peptide. The black solid lines show the corresponding linear and nonlinear fitting results.
Fig. 6
Fig. 6 The raw time activity curves of the first 20 min derived from one representative animal of each group in (A) tumor ROI and (B) muscle ROI. The definition of the symbol is the same as before, and the black solid lines show the corresponding nonlinear fitting results.
Fig. 7
Fig. 7 A. Bing potential (Bp) of Cy5.5-GX1 in each group, and binding potential was calculated as Bp = k3/k4 reflecting the binding affinity. The results were derived from GARTM. B. α + β values of Cy5.5-GX1 in each group of tumor and muscle regions, which represent the sum of the pharmacokinetic rate constants. C. The relevance between Bp and α + β values from all 12 tested animals, together with the linear regression result.

Equations (3)

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0 T ROI(t) dt ROI(T) =DVR 0 T ref(t)dt +ref(T)/ k 2 ref ROI(T) +in t (t> t * )
ROI(t)= R 1 ref(t)+{ k 2 R 1 k 2 /(1+B p ND )}ref(t)exp{ k 2 t/(1+B p ND )}
I(t)=A[1exp(αt)]+B[1exp(βt)]

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