Abstract

The recent massive Zika virus (ZIKV) outbreak illustrates the need for rapid and specific diagnostic techniques. Detecting ZIKV in biological samples poses unique problems: antibody detection of ZIKV is insufficient due to cross-reactivity of Zika antibodies with other flaviviruses, and nucleic acid and protein biomarkers for ZIKV are detectable at different stages of infection. Here, we describe a new optofluidic approach for the parallel detection of different molecular biomarkers using multimode interference (MMI) waveguides. We report differentiated, multiplex detection of both ZIKV biomarker types using multi-spot excitation at two visible wavelengths with over 98% fidelity by combining several analysis techniques.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Full Article  |  PDF Article
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    [Crossref] [PubMed]
  22. H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
    [Crossref] [PubMed]
  23. K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
    [Crossref] [PubMed]
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    [Crossref]
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    [Crossref] [PubMed]
  26. H. Cai, M. A. Stott, D. Ozcelik, J. W. Parks, A. R. Hawkins, and H. Schmidt, “On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood,” Biomicrofluidics 10(6), 064116 (2016).
    [Crossref] [PubMed]
  27. D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]

2018 (1)

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

2017 (3)

D. Ozcelik, H. Cai, K. D. Leake, A. R. Hawkins, and H. Schmidt, “Optofluidic bioanalysis: fundamentals and applications,” Nanophotonics 6(4), 647–661 (2017).
[Crossref] [PubMed]

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
[Crossref] [PubMed]

2016 (8)

D. Ozcelik, M. A. Stott, J. W. Parks, J. A. Black, T. A. Wall, A. R. Hawkins, and H. Schmidt, “Signal-to-noise enhancement in optical detection of single viruses with multi-spot excitation,” IEEE J. Sel. Top. Quantum Electron. 22(4), 4402406 (2016).
[Crossref] [PubMed]

H. Cai, M. A. Stott, D. Ozcelik, J. W. Parks, A. R. Hawkins, and H. Schmidt, “On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood,” Biomicrofluidics 10(6), 064116 (2016).
[Crossref] [PubMed]

J. J. Waggoner and B. A. Pinsky, “Zika virus: diagnostics for an emerging pandemic threat,” J. Clin. Microbiol. 54(4), 860–867 (2016).
[Crossref] [PubMed]

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

C. G. Victora, L. Schuler-Faccini, A. Matijasevich, E. Ribeiro, A. Pessoa, and F. C. Barros, “Microcephaly in Brazil: how to interpret reported numbers?” Lancet 387(10019), 621–624 (2016).
[Crossref] [PubMed]

D. W. Smith and J. Mackenzie, “Zika virus and Guillain-Barré syndrome: another viral cause to add to the list,” Lancet 387(10027), 1486–1488 (2016).
[Crossref] [PubMed]

M. T. Osterholm, “Ebola and Zika: Cautionary tales,” Science 353(6304), 1073 (2016).
[Crossref] [PubMed]

2015 (3)

A. Galindo-Fraga, E. Ochoa-Hein, J. Sifuentes-Osornio, and G. Ruiz-Palacios, “Zika virus: a new epidemic on our doorstep,” Rev. Invest. Clin. 67(6), 329–332 (2015).
[PubMed]

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

2014 (2)

S. Liu, Y. Zhao, J. W. Parks, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip,” Nano Lett. 14(8), 4816–4820 (2014).
[Crossref] [PubMed]

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

2013 (2)

O. Faye, O. Faye, D. Diallo, M. Diallo, M. Weidmann, and A. A. Sall, “Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes,” Virol. J. 10(1), 311 (2013).
[Crossref] [PubMed]

J. W. Parks, H. Cai, L. Zempoaltecatl, T. D. Yuzvinsky, K. Leake, A. R. Hawkins, and H. Schmidt, “Hybrid optofluidic integration,” Lab Chip 13(20), 4118–4123 (2013).
[Crossref] [PubMed]

2011 (2)

X. Fan and I. M. White, “Optofluidic microsystems for chemical and biological analysis,” Nat. Photonics 5(10), 591–597 (2011).
[Crossref] [PubMed]

H. Schmidt and A. R. Hawkins, “The photonic integration of non-solid media using optofluidics,” Nat. Photonics 5(10), 598–604 (2011).
[Crossref]

2008 (1)

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

2007 (1)

D. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Planar optofluidic chip for single particle detection, manipulation, and analysis,” Lab Chip 7(9), 1171–1175 (2007).
[Crossref] [PubMed]

2006 (1)

F. Watzinger, K. Ebner, and T. Lion, “Detection and monitoring of virus infections by real-time PCR,” Mol. Aspects Med. 27(2-3), 254–298 (2006).
[Crossref] [PubMed]

1998 (1)

G. Kuno, G. J. Chang, K. R. Tsuchiya, N. Karabatsos, and C. B. Cropp, “Phylogeny of the genus Flavivirus,” J. Virol. 72(1), 73–83 (1998).
[PubMed]

1995 (1)

L. B. Soldano and E. C. M. Pennings, “Optical multi-mode interference devices based on self-imaging: principles and applications,” J. Lightwave Technol. 13(4), 615–627 (1995).
[Crossref]

Aguiar, R. S.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Alfson, K.

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

Alfson, K. J.

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

Araujo, E. S. M.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Arregui, F. J.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Atkinson, B.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Baldanti, F.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Baldini, F.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Barros, F. C.

C. G. Victora, L. Schuler-Faccini, A. Matijasevich, E. Ribeiro, A. Pessoa, and F. C. Barros, “Microcephaly in Brazil: how to interpret reported numbers?” Lancet 387(10019), 621–624 (2016).
[Crossref] [PubMed]

Baudouin, L.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Beltramello, M.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Bianchi, S.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Black, J. A.

D. Ozcelik, M. A. Stott, J. W. Parks, J. A. Black, T. A. Wall, A. R. Hawkins, and H. Schmidt, “Signal-to-noise enhancement in optical detection of single viruses with multi-spot excitation,” IEEE J. Sel. Top. Quantum Electron. 22(4), 4402406 (2016).
[Crossref] [PubMed]

Blum, J.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Brasil, P.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Cai, H.

D. Ozcelik, H. Cai, K. D. Leake, A. R. Hawkins, and H. Schmidt, “Optofluidic bioanalysis: fundamentals and applications,” Nanophotonics 6(4), 647–661 (2017).
[Crossref] [PubMed]

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

H. Cai, M. A. Stott, D. Ozcelik, J. W. Parks, A. R. Hawkins, and H. Schmidt, “On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood,” Biomicrofluidics 10(6), 064116 (2016).
[Crossref] [PubMed]

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

J. W. Parks, H. Cai, L. Zempoaltecatl, T. D. Yuzvinsky, K. Leake, A. R. Hawkins, and H. Schmidt, “Hybrid optofluidic integration,” Lab Chip 13(20), 4118–4123 (2013).
[Crossref] [PubMed]

Calvet, G.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Cameroni, E.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Carrion, R.

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

Cassotta, A.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Chang, G. J.

G. Kuno, G. J. Chang, K. R. Tsuchiya, N. Karabatsos, and C. B. Cropp, “Phylogeny of the genus Flavivirus,” J. Virol. 72(1), 73–83 (1998).
[PubMed]

Chiavaioli, F.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Corti, D.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Cropp, C. B.

G. Kuno, G. J. Chang, K. R. Tsuchiya, N. Karabatsos, and C. B. Cropp, “Phylogeny of the genus Flavivirus,” J. Virol. 72(1), 73–83 (1998).
[PubMed]

de Filippis, A. M. B.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

de Filippis, I.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

de Mendonça, M. C. L.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

de Oliveira, L.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

de Sequeira, P. C.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Deamer, D. W.

S. Liu, Y. Zhao, J. W. Parks, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip,” Nano Lett. 14(8), 4816–4820 (2014).
[Crossref] [PubMed]

D. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Planar optofluidic chip for single particle detection, manipulation, and analysis,” Lab Chip 7(9), 1171–1175 (2007).
[Crossref] [PubMed]

Del Villar, I.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Diallo, D.

O. Faye, O. Faye, D. Diallo, M. Diallo, M. Weidmann, and A. A. Sall, “Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes,” Virol. J. 10(1), 311 (2013).
[Crossref] [PubMed]

Diallo, M.

O. Faye, O. Faye, D. Diallo, M. Diallo, M. Weidmann, and A. A. Sall, “Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes,” Virol. J. 10(1), 311 (2013).
[Crossref] [PubMed]

Dos Santos, F. B.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Dowall, S.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Du, K.

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

Duffy, M. R.

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

Ebner, K.

F. Watzinger, K. Ebner, and T. Lion, “Detection and monitoring of virus infections by real-time PCR,” Mol. Aspects Med. 27(2-3), 254–298 (2006).
[Crossref] [PubMed]

Espinosa, D. A.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Fabri, A.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Fan, X.

X. Fan and I. M. White, “Optofluidic microsystems for chemical and biological analysis,” Nat. Photonics 5(10), 591–597 (2011).
[Crossref] [PubMed]

Faye, O.

O. Faye, O. Faye, D. Diallo, M. Diallo, M. Weidmann, and A. A. Sall, “Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes,” Virol. J. 10(1), 311 (2013).
[Crossref] [PubMed]

O. Faye, O. Faye, D. Diallo, M. Diallo, M. Weidmann, and A. A. Sall, “Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes,” Virol. J. 10(1), 311 (2013).
[Crossref] [PubMed]

Foglierini, M.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Galindo-Fraga, A.

A. Galindo-Fraga, E. Ochoa-Hein, J. Sifuentes-Osornio, and G. Ruiz-Palacios, “Zika virus: a new epidemic on our doorstep,” Rev. Invest. Clin. 67(6), 329–332 (2015).
[PubMed]

Ghawche, F.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Giannetti, A.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Graham, V.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Griffiths, A.

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

Harris, E.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Hawkins, A.

D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
[Crossref] [PubMed]

Hawkins, A. R.

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

D. Ozcelik, H. Cai, K. D. Leake, A. R. Hawkins, and H. Schmidt, “Optofluidic bioanalysis: fundamentals and applications,” Nanophotonics 6(4), 647–661 (2017).
[Crossref] [PubMed]

H. Cai, M. A. Stott, D. Ozcelik, J. W. Parks, A. R. Hawkins, and H. Schmidt, “On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood,” Biomicrofluidics 10(6), 064116 (2016).
[Crossref] [PubMed]

D. Ozcelik, M. A. Stott, J. W. Parks, J. A. Black, T. A. Wall, A. R. Hawkins, and H. Schmidt, “Signal-to-noise enhancement in optical detection of single viruses with multi-spot excitation,” IEEE J. Sel. Top. Quantum Electron. 22(4), 4402406 (2016).
[Crossref] [PubMed]

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

S. Liu, Y. Zhao, J. W. Parks, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip,” Nano Lett. 14(8), 4816–4820 (2014).
[Crossref] [PubMed]

J. W. Parks, H. Cai, L. Zempoaltecatl, T. D. Yuzvinsky, K. Leake, A. R. Hawkins, and H. Schmidt, “Hybrid optofluidic integration,” Lab Chip 13(20), 4118–4123 (2013).
[Crossref] [PubMed]

H. Schmidt and A. R. Hawkins, “The photonic integration of non-solid media using optofluidics,” Nat. Photonics 5(10), 598–604 (2011).
[Crossref]

D. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Planar optofluidic chip for single particle detection, manipulation, and analysis,” Lab Chip 7(9), 1171–1175 (2007).
[Crossref] [PubMed]

Hewson, R.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Jaconi, S.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Jain, A.

D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
[Crossref] [PubMed]

Johnson, A. J.

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

Karabatsos, N.

G. Kuno, G. J. Chang, K. R. Tsuchiya, N. Karabatsos, and C. B. Cropp, “Phylogeny of the genus Flavivirus,” J. Virol. 72(1), 73–83 (1998).
[PubMed]

Kosoy, O. L.

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

Kuno, G.

G. Kuno, G. J. Chang, K. R. Tsuchiya, N. Karabatsos, and C. B. Cropp, “Phylogeny of the genus Flavivirus,” J. Virol. 72(1), 73–83 (1998).
[PubMed]

Lambert, A. J.

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

Lanciotti, R. S.

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

Lanzavecchia, A.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Larre, P.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Lastere, S.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Laven, J. J.

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

Leake, K.

J. W. Parks, H. Cai, L. Zempoaltecatl, T. D. Yuzvinsky, K. Leake, A. R. Hawkins, and H. Schmidt, “Hybrid optofluidic integration,” Lab Chip 13(20), 4118–4123 (2013).
[Crossref] [PubMed]

Leake, K. D.

D. Ozcelik, H. Cai, K. D. Leake, A. R. Hawkins, and H. Schmidt, “Optofluidic bioanalysis: fundamentals and applications,” Nanophotonics 6(4), 647–661 (2017).
[Crossref] [PubMed]

Leparc-Goffart, I.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Lion, T.

F. Watzinger, K. Ebner, and T. Lion, “Detection and monitoring of virus infections by real-time PCR,” Mol. Aspects Med. 27(2-3), 254–298 (2006).
[Crossref] [PubMed]

Liu, S.

S. Liu, Y. Zhao, J. W. Parks, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip,” Nano Lett. 14(8), 4816–4820 (2014).
[Crossref] [PubMed]

Lunt, E. J.

D. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Planar optofluidic chip for single particle detection, manipulation, and analysis,” Lab Chip 7(9), 1171–1175 (2007).
[Crossref] [PubMed]

Mackenzie, J.

D. W. Smith and J. Mackenzie, “Zika virus and Guillain-Barré syndrome: another viral cause to add to the list,” Lancet 387(10027), 1486–1488 (2016).
[Crossref] [PubMed]

Mallet, H.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Mathies, R. A.

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

Matias, I. R.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Matijasevich, A.

C. G. Victora, L. Schuler-Faccini, A. Matijasevich, E. Ribeiro, A. Pessoa, and F. C. Barros, “Microcephaly in Brazil: how to interpret reported numbers?” Lancet 387(10019), 621–624 (2016).
[Crossref] [PubMed]

Mele, F.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Melo, A. S. O.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Minola, A.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Musso, D.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Nogueira, R. M. R.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Ochoa-Hein, E.

A. Galindo-Fraga, E. Ochoa-Hein, J. Sifuentes-Osornio, and G. Ruiz-Palacios, “Zika virus: a new epidemic on our doorstep,” Rev. Invest. Clin. 67(6), 329–332 (2015).
[PubMed]

Oehler, E.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Osterholm, M. T.

M. T. Osterholm, “Ebola and Zika: Cautionary tales,” Science 353(6304), 1073 (2016).
[Crossref] [PubMed]

Ozcelik, D.

D. Ozcelik, H. Cai, K. D. Leake, A. R. Hawkins, and H. Schmidt, “Optofluidic bioanalysis: fundamentals and applications,” Nanophotonics 6(4), 647–661 (2017).
[Crossref] [PubMed]

D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
[Crossref] [PubMed]

H. Cai, M. A. Stott, D. Ozcelik, J. W. Parks, A. R. Hawkins, and H. Schmidt, “On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood,” Biomicrofluidics 10(6), 064116 (2016).
[Crossref] [PubMed]

D. Ozcelik, M. A. Stott, J. W. Parks, J. A. Black, T. A. Wall, A. R. Hawkins, and H. Schmidt, “Signal-to-noise enhancement in optical detection of single viruses with multi-spot excitation,” IEEE J. Sel. Top. Quantum Electron. 22(4), 4402406 (2016).
[Crossref] [PubMed]

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

Park, M.

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

Parks, J. W.

D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
[Crossref] [PubMed]

D. Ozcelik, M. A. Stott, J. W. Parks, J. A. Black, T. A. Wall, A. R. Hawkins, and H. Schmidt, “Signal-to-noise enhancement in optical detection of single viruses with multi-spot excitation,” IEEE J. Sel. Top. Quantum Electron. 22(4), 4402406 (2016).
[Crossref] [PubMed]

H. Cai, M. A. Stott, D. Ozcelik, J. W. Parks, A. R. Hawkins, and H. Schmidt, “On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood,” Biomicrofluidics 10(6), 064116 (2016).
[Crossref] [PubMed]

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

S. Liu, Y. Zhao, J. W. Parks, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip,” Nano Lett. 14(8), 4816–4820 (2014).
[Crossref] [PubMed]

J. W. Parks, H. Cai, L. Zempoaltecatl, T. D. Yuzvinsky, K. Leake, A. R. Hawkins, and H. Schmidt, “Hybrid optofluidic integration,” Lab Chip 13(20), 4118–4123 (2013).
[Crossref] [PubMed]

Patterson, J. L.

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

Pedotti, M.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Pennings, E. C. M.

L. B. Soldano and E. C. M. Pennings, “Optical multi-mode interference devices based on self-imaging: principles and applications,” J. Lightwave Technol. 13(4), 615–627 (1995).
[Crossref]

Percivalle, E.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Pessoa, A.

C. G. Victora, L. Schuler-Faccini, A. Matijasevich, E. Ribeiro, A. Pessoa, and F. C. Barros, “Microcephaly in Brazil: how to interpret reported numbers?” Lancet 387(10019), 621–624 (2016).
[Crossref] [PubMed]

Pinsky, B. A.

J. J. Waggoner and B. A. Pinsky, “Zika virus: diagnostics for an emerging pandemic threat,” J. Clin. Microbiol. 54(4), 860–867 (2016).
[Crossref] [PubMed]

Ribeiro, E.

C. G. Victora, L. Schuler-Faccini, A. Matijasevich, E. Ribeiro, A. Pessoa, and F. C. Barros, “Microcephaly in Brazil: how to interpret reported numbers?” Lancet 387(10019), 621–624 (2016).
[Crossref] [PubMed]

Rudenko, M. I.

D. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Planar optofluidic chip for single particle detection, manipulation, and analysis,” Lab Chip 7(9), 1171–1175 (2007).
[Crossref] [PubMed]

Ruiz-Palacios, G.

A. Galindo-Fraga, E. Ochoa-Hein, J. Sifuentes-Osornio, and G. Ruiz-Palacios, “Zika virus: a new epidemic on our doorstep,” Rev. Invest. Clin. 67(6), 329–332 (2015).
[PubMed]

Sall, A. A.

O. Faye, O. Faye, D. Diallo, M. Diallo, M. Weidmann, and A. A. Sall, “Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes,” Virol. J. 10(1), 311 (2013).
[Crossref] [PubMed]

Sallusto, F.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Sampaio, S. A.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Schmidt, H.

D. Ozcelik, H. Cai, K. D. Leake, A. R. Hawkins, and H. Schmidt, “Optofluidic bioanalysis: fundamentals and applications,” Nanophotonics 6(4), 647–661 (2017).
[Crossref] [PubMed]

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
[Crossref] [PubMed]

H. Cai, M. A. Stott, D. Ozcelik, J. W. Parks, A. R. Hawkins, and H. Schmidt, “On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood,” Biomicrofluidics 10(6), 064116 (2016).
[Crossref] [PubMed]

D. Ozcelik, M. A. Stott, J. W. Parks, J. A. Black, T. A. Wall, A. R. Hawkins, and H. Schmidt, “Signal-to-noise enhancement in optical detection of single viruses with multi-spot excitation,” IEEE J. Sel. Top. Quantum Electron. 22(4), 4402406 (2016).
[Crossref] [PubMed]

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

S. Liu, Y. Zhao, J. W. Parks, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip,” Nano Lett. 14(8), 4816–4820 (2014).
[Crossref] [PubMed]

J. W. Parks, H. Cai, L. Zempoaltecatl, T. D. Yuzvinsky, K. Leake, A. R. Hawkins, and H. Schmidt, “Hybrid optofluidic integration,” Lab Chip 13(20), 4118–4123 (2013).
[Crossref] [PubMed]

H. Schmidt and A. R. Hawkins, “The photonic integration of non-solid media using optofluidics,” Nat. Photonics 5(10), 598–604 (2011).
[Crossref]

D. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Planar optofluidic chip for single particle detection, manipulation, and analysis,” Lab Chip 7(9), 1171–1175 (2007).
[Crossref] [PubMed]

Schrago, C. G.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Schuler-Faccini, L.

C. G. Victora, L. Schuler-Faccini, A. Matijasevich, E. Ribeiro, A. Pessoa, and F. C. Barros, “Microcephaly in Brazil: how to interpret reported numbers?” Lancet 387(10019), 621–624 (2016).
[Crossref] [PubMed]

Sifuentes-Osornio, J.

A. Galindo-Fraga, E. Ochoa-Hein, J. Sifuentes-Osornio, and G. Ruiz-Palacios, “Zika virus: a new epidemic on our doorstep,” Rev. Invest. Clin. 67(6), 329–332 (2015).
[PubMed]

Simmons, C. P.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Simonelli, L.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Smith, D. W.

D. W. Smith and J. Mackenzie, “Zika virus and Guillain-Barré syndrome: another viral cause to add to the list,” Lancet 387(10027), 1486–1488 (2016).
[Crossref] [PubMed]

Soldano, L. B.

L. B. Soldano and E. C. M. Pennings, “Optical multi-mode interference devices based on self-imaging: principles and applications,” J. Lightwave Technol. 13(4), 615–627 (1995).
[Crossref]

Stambaugh, A.

D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

Stanfield, S. M.

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

Stettler, K.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Stott, M. A.

D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
[Crossref] [PubMed]

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

D. Ozcelik, M. A. Stott, J. W. Parks, J. A. Black, T. A. Wall, A. R. Hawkins, and H. Schmidt, “Signal-to-noise enhancement in optical detection of single viruses with multi-spot excitation,” IEEE J. Sel. Top. Quantum Electron. 22(4), 4402406 (2016).
[Crossref] [PubMed]

H. Cai, M. A. Stott, D. Ozcelik, J. W. Parks, A. R. Hawkins, and H. Schmidt, “On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood,” Biomicrofluidics 10(6), 064116 (2016).
[Crossref] [PubMed]

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

Tanuri, A.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Thompson, F. L.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Tombelli, S.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Trono, C.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Tschoeke, D. A.

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Tsuchiya, K. R.

G. Kuno, G. J. Chang, K. R. Tsuchiya, N. Karabatsos, and C. B. Cropp, “Phylogeny of the genus Flavivirus,” J. Virol. 72(1), 73–83 (1998).
[PubMed]

Valour, F.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Vanzetta, F.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Varani, L.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

Velez, J. O.

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

Victora, C. G.

C. G. Victora, L. Schuler-Faccini, A. Matijasevich, E. Ribeiro, A. Pessoa, and F. C. Barros, “Microcephaly in Brazil: how to interpret reported numbers?” Lancet 387(10019), 621–624 (2016).
[Crossref] [PubMed]

Waggoner, J. J.

J. J. Waggoner and B. A. Pinsky, “Zika virus: diagnostics for an emerging pandemic threat,” J. Clin. Microbiol. 54(4), 860–867 (2016).
[Crossref] [PubMed]

Wall, T. A.

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

D. Ozcelik, M. A. Stott, J. W. Parks, J. A. Black, T. A. Wall, A. R. Hawkins, and H. Schmidt, “Signal-to-noise enhancement in optical detection of single viruses with multi-spot excitation,” IEEE J. Sel. Top. Quantum Electron. 22(4), 4402406 (2016).
[Crossref] [PubMed]

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

Watrin, L.

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

Watzinger, F.

F. Watzinger, K. Ebner, and T. Lion, “Detection and monitoring of virus infections by real-time PCR,” Mol. Aspects Med. 27(2-3), 254–298 (2006).
[Crossref] [PubMed]

Weidmann, M.

O. Faye, O. Faye, D. Diallo, M. Diallo, M. Weidmann, and A. A. Sall, “Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes,” Virol. J. 10(1), 311 (2013).
[Crossref] [PubMed]

White, I. M.

X. Fan and I. M. White, “Optofluidic microsystems for chemical and biological analysis,” Nat. Photonics 5(10), 591–597 (2011).
[Crossref] [PubMed]

Yin, D.

D. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Planar optofluidic chip for single particle detection, manipulation, and analysis,” Lab Chip 7(9), 1171–1175 (2007).
[Crossref] [PubMed]

Yuzvinsky, T. D.

J. W. Parks, H. Cai, L. Zempoaltecatl, T. D. Yuzvinsky, K. Leake, A. R. Hawkins, and H. Schmidt, “Hybrid optofluidic integration,” Lab Chip 13(20), 4118–4123 (2013).
[Crossref] [PubMed]

Zamarreño, C. R.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Zempoaltecatl, L.

J. W. Parks, H. Cai, L. Zempoaltecatl, T. D. Yuzvinsky, K. Leake, A. R. Hawkins, and H. Schmidt, “Hybrid optofluidic integration,” Lab Chip 13(20), 4118–4123 (2013).
[Crossref] [PubMed]

Zhao, Y.

S. Liu, Y. Zhao, J. W. Parks, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip,” Nano Lett. 14(8), 4816–4820 (2014).
[Crossref] [PubMed]

Zubiate, P.

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

ACS Sens (1)

F. Chiavaioli, P. Zubiate, I. Del Villar, C. R. Zamarreño, A. Giannetti, S. Tombelli, C. Trono, F. J. Arregui, I. R. Matias, and F. Baldini, “Femtomolar detection by nanocoated fiber label-free biosensors,” ACS Sens 3(5), 936–943 (2018).
[Crossref] [PubMed]

Biomicrofluidics (1)

H. Cai, M. A. Stott, D. Ozcelik, J. W. Parks, A. R. Hawkins, and H. Schmidt, “On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood,” Biomicrofluidics 10(6), 064116 (2016).
[Crossref] [PubMed]

Biosens. Bioelectron. (1)

K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, and R. A. Mathies, “Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of ebola virus,” Biosens. Bioelectron. 91, 489–496 (2017).
[Crossref] [PubMed]

Emerg. Infect. Dis. (1)

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert, A. J. Johnson, S. M. Stanfield, and M. R. Duffy, “Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007,” Emerg. Infect. Dis. 14(8), 1232–1239 (2008).
[Crossref] [PubMed]

Euro Surveill. (1)

E. Oehler, L. Watrin, P. Larre, I. Leparc-Goffart, S. Lastere, F. Valour, L. Baudouin, H. Mallet, D. Musso, and F. Ghawche, “Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013,” Euro Surveill. 19(9), 20720 (2014).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

D. Ozcelik, M. A. Stott, J. W. Parks, J. A. Black, T. A. Wall, A. R. Hawkins, and H. Schmidt, “Signal-to-noise enhancement in optical detection of single viruses with multi-spot excitation,” IEEE J. Sel. Top. Quantum Electron. 22(4), 4402406 (2016).
[Crossref] [PubMed]

J. Clin. Microbiol. (1)

J. J. Waggoner and B. A. Pinsky, “Zika virus: diagnostics for an emerging pandemic threat,” J. Clin. Microbiol. 54(4), 860–867 (2016).
[Crossref] [PubMed]

J. Lightwave Technol. (1)

L. B. Soldano and E. C. M. Pennings, “Optical multi-mode interference devices based on self-imaging: principles and applications,” J. Lightwave Technol. 13(4), 615–627 (1995).
[Crossref]

J. Virol. (1)

G. Kuno, G. J. Chang, K. R. Tsuchiya, N. Karabatsos, and C. B. Cropp, “Phylogeny of the genus Flavivirus,” J. Virol. 72(1), 73–83 (1998).
[PubMed]

Lab Chip (2)

D. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Planar optofluidic chip for single particle detection, manipulation, and analysis,” Lab Chip 7(9), 1171–1175 (2007).
[Crossref] [PubMed]

J. W. Parks, H. Cai, L. Zempoaltecatl, T. D. Yuzvinsky, K. Leake, A. R. Hawkins, and H. Schmidt, “Hybrid optofluidic integration,” Lab Chip 13(20), 4118–4123 (2013).
[Crossref] [PubMed]

Lancet (2)

D. W. Smith and J. Mackenzie, “Zika virus and Guillain-Barré syndrome: another viral cause to add to the list,” Lancet 387(10027), 1486–1488 (2016).
[Crossref] [PubMed]

C. G. Victora, L. Schuler-Faccini, A. Matijasevich, E. Ribeiro, A. Pessoa, and F. C. Barros, “Microcephaly in Brazil: how to interpret reported numbers?” Lancet 387(10019), 621–624 (2016).
[Crossref] [PubMed]

Lancet Infect. Dis. (1)

G. Calvet, R. S. Aguiar, A. S. O. Melo, S. A. Sampaio, I. de Filippis, A. Fabri, E. S. M. Araujo, P. C. de Sequeira, M. C. L. de Mendonça, L. de Oliveira, D. A. Tschoeke, C. G. Schrago, F. L. Thompson, P. Brasil, F. B. Dos Santos, R. M. R. Nogueira, A. Tanuri, and A. M. B. de Filippis, “Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,” Lancet Infect. Dis. 16(6), 653–660 (2016).
[Crossref] [PubMed]

Mol. Aspects Med. (1)

F. Watzinger, K. Ebner, and T. Lion, “Detection and monitoring of virus infections by real-time PCR,” Mol. Aspects Med. 27(2-3), 254–298 (2006).
[Crossref] [PubMed]

Nano Lett. (1)

S. Liu, Y. Zhao, J. W. Parks, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip,” Nano Lett. 14(8), 4816–4820 (2014).
[Crossref] [PubMed]

Nanophotonics (1)

D. Ozcelik, H. Cai, K. D. Leake, A. R. Hawkins, and H. Schmidt, “Optofluidic bioanalysis: fundamentals and applications,” Nanophotonics 6(4), 647–661 (2017).
[Crossref] [PubMed]

Nat. Photonics (2)

X. Fan and I. M. White, “Optofluidic microsystems for chemical and biological analysis,” Nat. Photonics 5(10), 591–597 (2011).
[Crossref] [PubMed]

H. Schmidt and A. R. Hawkins, “The photonic integration of non-solid media using optofluidics,” Nat. Photonics 5(10), 598–604 (2011).
[Crossref]

Proc. Natl. Acad. Sci. U.S.A. (1)

D. Ozcelik, J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. Parks, A. R. Hawkins, and H. Schmidt, “Optofluidic wavelength division multiplexing for single-virus detection,” Proc. Natl. Acad. Sci. U.S.A. 112(42), 12933–12937 (2015).
[Crossref] [PubMed]

Rev. Invest. Clin. (1)

A. Galindo-Fraga, E. Ochoa-Hein, J. Sifuentes-Osornio, and G. Ruiz-Palacios, “Zika virus: a new epidemic on our doorstep,” Rev. Invest. Clin. 67(6), 329–332 (2015).
[PubMed]

Sci. Rep. (2)

H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, and H. Schmidt, “Optofluidic analysis system for amplification-free, direct detection of Ebola infection,” Sci. Rep. 5(1), 14494 (2015).
[Crossref] [PubMed]

D. Ozcelik, A. Jain, A. Stambaugh, M. A. Stott, J. W. Parks, A. Hawkins, and H. Schmidt, “Scalable spatial-spectral multiplexing of single-virus detection using multimode interference waveguides,” Sci. Rep. 7(1), 12199 (2017).
[Crossref] [PubMed]

Science (2)

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta, S. Bianchi, F. Vanzetta, A. Minola, S. Jaconi, F. Mele, M. Foglierini, M. Pedotti, L. Simonelli, S. Dowall, B. Atkinson, E. Percivalle, C. P. Simmons, L. Varani, J. Blum, F. Baldanti, E. Cameroni, R. Hewson, E. Harris, A. Lanzavecchia, F. Sallusto, and D. Corti, “Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection,” Science 353(6301), 823–826 (2016).
[Crossref] [PubMed]

M. T. Osterholm, “Ebola and Zika: Cautionary tales,” Science 353(6304), 1073 (2016).
[Crossref] [PubMed]

Virol. J. (1)

O. Faye, O. Faye, D. Diallo, M. Diallo, M. Weidmann, and A. A. Sall, “Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes,” Virol. J. 10(1), 311 (2013).
[Crossref] [PubMed]

Other (2)

WHO, “WHO to fast-track availability of diagnostics for Zika virus”, http://www.who.int/medicines/news/fast_track_diagnostics_zika/en/ (2016).

https://www.euroimmun.com/products/indications/infektions-serologie/zika-viruses.html

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Figures (3)

Fig. 1
Fig. 1 a) Scanning electron microscope image of fabricated ARROW optofluidic device, with top down multi-mode spot quantum dot images for λ = 556 nm and λ = 633 nm shown on the right, with their respective colors (insert: photo of complete 1cm2 ARROW optofluidic chip), b) Product from the nucleic acid and protein solid-phase extraction assays used for target isolation with high specificity, c) Particle fluorescence traces detected on ARROW optofluidic chip for the protein detection complex (top: negative control (no NS1 protein); bottom: positive control (with NS1 protein)).
Fig. 2
Fig. 2 a) Particle fluorescence trace of both nucleic acid and protein complexes detected in an MMI ARROW chip and excited first with only λ1 = 633 nm, then with only λ2 = 566 nm, and finally with λ1 and λ2, b) Fluorescence signal from a single nucleic acid complex showing 7 peaks with the signal time (Ttot) and characteristic delta t, δtR = 0.55ms, annotated on the fluorescence signal, c) Fluorescence signal from a single protein complex showing 8 peaks with the signal time (Ttot) and characteristic delta t, δtG = 0.34ms, annotated on the fluorescence signal.
Fig. 3
Fig. 3 a) Corresponding single-particle autocorrelation signals for both a red nucleic acid signal and a green protein signal. Multiple peaks are observed at multiples of δtG, = 0.34 ms and δtR = 0.55 ms, b) Corresponding enhanced signal using shift-multiply versus δt of the signal shown in (a), signals show an increased SNR when shifted by the correct δt c) Segment of the particle fluorescence trace that was excited with both colors. Events were identified using single particle autocorrelations, shift-multiply algorithms, and total peak duration analysis. Over 98% of signals were identified. Of 215 total signals, 134 were identified as Nucleic Acid complexes, annotated by red squares and 77 were identified as Protein complexes, annotated by green circles.

Equations (3)

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N=  n c w 2
S( t, δt )= m=1 N1 F(tmδt)
N i =  T Tot,i δt i

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