Abstract

We used triple silent substitution stimuli to characterize human S-cone electroretinograms (ERGs) in normal trichromats. Short-wavelength-cone (S-cone) ERGs were found to have different morphological features and temporal frequency response characteristics compared to ERGs derived from L-cones, M-cones, and rod photoreceptors in normal participants. Furthermore, in two cases of retinal pathology, blue cone monochromatism (BCM) and enhanced S-cone syndrome (ESCS), S-cone ERGs elicited by our stimuli were preserved and enhanced, respectively. The results from both normal and pathological retinae demonstrate that triple silent substitution stimuli can be used to generate ERGs that provide an assay of human S-cone function.

© 2018 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Temporal characteristics of L- and M-cone isolating steady-state electroretinograms

Deepika Kommanapalli, Ian J. Murray, Jan Kremers, Neil R. A. Parry, and Declan J. McKeefry
J. Opt. Soc. Am. A 31(4) A113-A120 (2014)

Cone-isolating ON–OFF electroretinogram for studying chromatic pathways in the retina

James A. Kuchenbecker, Scott H. Greenwald, Maureen Neitz, and Jay Neitz
J. Opt. Soc. Am. A 31(4) A208-A213 (2014)

Photoreceptor-specific light adaptation of critical flicker frequency in trichromat and dichromat observers

Cord Huchzermeyer, Cristiane M. G. Martins, Balázs Nagy, Mirella T. S. Barboni, Dora F. Ventura, Marcelo F. Costa, and Jan Kremers
J. Opt. Soc. Am. A 35(4) B106-B113 (2018)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (2)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription