Abstract

A novel phosphorescent probe based on ion-paired iridium(III) complex has been designed and synthesized by incorporating α,β-unsaturated ketone moiety in the cationic component. The phosphorescent intensity of cationic component is sensitive to bithiols, such as cysteine and homocysteine, based on the addition reaction of bithiols with α,β-unsaturated ketone moiety, while that of the anionic component remains unchanged. Thus, this ion-paired iridium(III) complex can be used for ratiometric luminescence sensing and imaging of intracellular biothiols with excellent sensing performance. Moreover, the long phosphorescence lifetime of the cationic component is also sensitive to bithiols. Hence, this ion-paired iridium(III) complex has been further used for time-resolved luminescence imaging of intracellular biothiols. As far as we know, this is the first report about molecular probe for both ratiometric and time-resolved luminescence imaging of intracellular biothiols.

© 2016 Optical Society of America

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    [Crossref] [PubMed]
  4. Q. Zhao, F. Li, and C. Huang, “Phosphorescent chemosensors based on heavy-metal complexes,” Chem. Soc. Rev. 39(8), 3007–3030 (2010).
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  5. K. H. Leung, H. Z. He, B. He, H. J. Zhong, S. Lin, Y. T. Wang, D. L. Ma, and C. H. Leung, “Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe,” Chem. Sci. (Camb.) 6(4), 2166–2171 (2015).
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    [Crossref]
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    [Crossref]
  30. S. Liu, J. Zhang, D. Shen, H. Liang, X. Liu, Q. Zhao, and W. Huang, “Reaction-based phosphorescent nanosensor for ratiometric and time-resolved luminescence imaging of fluoride in live cells,” Chem. Commun. (Camb.) 51(64), 12839–12842 (2015).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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2016 (3)

P. Tao, W. L. Li, J. Zhang, S. Guo, Q. Zhao, H. Wang, B. Wei, S. J. Liu, X. H. Zhou, Q. Yu, B. S. Xu, and W. Huang, “Facile synthesis of highly efficient lepidine-based phosphorescent iridium(III) complexes for yellow and white organic light-emitting diodes,” Adv. Funct. Mater. 26(6), 881–894 (2016).
[Crossref]

Y. Ma, H. Liang, Y. Zeng, H. R. Yang, C. L. Ho, W. J. Xu, Q. Zhao, W. Huang, and W. Y. Wong, “Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations,” Chem. Sci. (Camb.) 7(5), 3338–3346 (2016).
[Crossref]

Z. Mao, M. Wang, J. Liu, L. J. Liu, S. M. Y. Lee, C. H. Leung, and D. L. Ma, “A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish,” Chem. Commun. (Camb.) 52(24), 4450–4453 (2016).
[Crossref] [PubMed]

2015 (7)

Q. Zhao, X. B. Zhou, T. Y. Cao, K. Y. Zhang, L. J. Yang, S. J. Liu, H. Liang, H. R. Yang, F. Y. Li, and W. Huang, “Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging,” Chem. Sci. (Camb.) 6(3), 1825–1831 (2015).
[Crossref]

K. Y. Zhang, J. Zhang, Y. Liu, S. Liu, P. Zhang, Q. Zhao, Y. Tang, and W. Huang, “Core–shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy,” Chem. Sci. (Camb.) 6(1), 301–307 (2015).
[Crossref]

S. Liu, J. Zhang, D. Shen, H. Liang, X. Liu, Q. Zhao, and W. Huang, “Reaction-based phosphorescent nanosensor for ratiometric and time-resolved luminescence imaging of fluoride in live cells,” Chem. Commun. (Camb.) 51(64), 12839–12842 (2015).
[Crossref] [PubMed]

S. Liu, H. Liang, K. Y. Zhang, Q. Zhao, X. Zhou, W. Xu, and W. Huang, “A multifunctional phosphorescent iridium(III) complex for specific nucleus staining and hypoxia monitoring,” Chem. Commun. (Camb.) 51(37), 7943–7946 (2015).
[Crossref] [PubMed]

R. I. Dmitriev, S. M. Borisov, H. Düssmann, S. Sun, B. J. Müller, J. Prehn, V. P. Baklaushev, I. Klimant, and D. B. Papkovsky, “Versatile conjugated polymer nanoparticles for high-resolution O2 Imaging in cells and 3D tissue models,” ACS Nano 9(5), 5275–5288 (2015).
[Crossref] [PubMed]

M. H. Lee, J. S. Kim, and J. L. Sessler, “Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules,” Chem. Soc. Rev. 44(13), 4185–4191 (2015).
[Crossref] [PubMed]

K. H. Leung, H. Z. He, B. He, H. J. Zhong, S. Lin, Y. T. Wang, D. L. Ma, and C. H. Leung, “Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe,” Chem. Sci. (Camb.) 6(4), 2166–2171 (2015).
[Crossref]

2014 (8)

M. Sandroni and E. Zysman-Colman, “Exploring energy transfer in luminescent heterometallic ruthenium-iridium ion pairs,” Dalton Trans. 43(9), 3676–3680 (2014).
[Crossref] [PubMed]

A. Ionescu, E. I. Szerb, Y. J. Yadav, A. M. Talarico, M. Ghedini, and N. Godbert, “Orotate containing anionic luminescent iridium(III) complexes and their use in soft salts,” Dalton Trans. 43(2), 784–789 (2014).
[Crossref] [PubMed]

L. Ying, C. L. Ho, H. Wu, Y. Cao, and W. Y. Wong, “White polymer light-emitting devices for solid-state lighting: materials, devices, and recent progress,” Adv. Mater. 26(16), 2459–2473 (2014).
[Crossref] [PubMed]

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
[Crossref] [PubMed]

D. Aigner, R. I. Dmitriev, S. M. Borisov, D. B. Papkovsky, and I. Klimant, “pH-sensitive perylene bisimide probes for live cell fluorescence lifetime imaging,” J. Mater. Chem. B Mater. Biol. Med. 2(39), 6792–6801 (2014).
[Crossref]

D. L. Ma, D. S. H. Chan, and C. H. Leung, “Group 9 organometallic compounds for therapeutic and bioanalytical applications,” Acc. Chem. Res. 47(12), 3614–3631 (2014).
[Crossref] [PubMed]

E. Baggaley, M. R. Gill, N. H. Green, D. Turton, I. V. Sazanovich, S. W. Botchway, C. Smythe, J. W. Haycock, J. A. Weinstein, and J. A. Thomas, “Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA,” Angew. Chem. Int. Ed. Engl. 53(13), 3367–3371 (2014).
[Crossref] [PubMed]

W. Xu, X. Zhao, W. Lv, H. Yang, S. Liu, H. Liang, Z. Tu, H. Xu, W. Qiao, Q. Zhao, and W. Huang, “Rational design of phosphorescent chemodosimeter for reaction-based one- and two-photon and time-resolved luminescent imaging of biothiols in living cells,” Adv. Healthc. Mater. 3(5), 658–669 (2014).
[Crossref] [PubMed]

2013 (3)

L. Gu, D. J. Hall, Z. Qin, E. Anglin, J. Joo, D. J. Mooney, S. B. Howell, and M. J. Sailor, “In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles,” Nat. Commun. 4, 2326 (2013).
[Crossref] [PubMed]

M. H. Lee, J. H. Han, J. H. Lee, N. Park, R. Kumar, C. Kang, and J. S. Kim, “Two-color probe to monitor a wide range of pH values in cells,” Angew. Chem. Int. Ed. Engl. 52(24), 6206–6209 (2013).
[Crossref] [PubMed]

C. Shi, H. Sun, X. Tang, W. Lv, H. Yan, Q. Zhao, J. Wang, and W. Huang, “Variable photophysical properties of phosphorescent iridium(III) complexes triggered by closo- and nido-carborane substitution,” Angew. Chem. Int. Ed. Engl. 52(50), 13434–13438 (2013).
[Crossref] [PubMed]

2012 (1)

R. D. Costa, E. Ortí, H. J. Bolink, F. Monti, G. Accorsi, and N. Armaroli, “Luminescent ionic transition-metal complexes for light-emitting electrochemical cells,” Angew. Chem. Int. Ed. Engl. 51(33), 8178–8211 (2012).
[Crossref] [PubMed]

2011 (5)

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

W. J. Xu, S. J. Liu, T. C. Ma, Q. Zhao, A. Pertegas, D. Tordera, H. J. Bolink, S. H. Ye, X. M. Liu, S. Sun, and W. Huang, “p–n Metallophosphor based on cationic iridium(III) complex for solid-state light-emitting electrochemical cells,” J. Mater. Chem. 21(36), 13999–14007 (2011).
[Crossref]

Y. You, S. Lee, T. Kim, K. Ohkubo, W. S. Chae, S. Fukuzumi, G. J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Y. Ma, S. J. Liu, H. R. Yang, Y. Q. Wu, C. J. Yang, X. M. Liu, Q. Zhao, H. Z. Wu, J. C. Liang, F. Y. Li, and W. Huang, “Water-soluble phosphorescent iridium(III) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells,” J. Mater. Chem. 21(47), 18974–18982 (2011).
[Crossref]

Y. You, S. Lee, T. Kim, K. Ohkubo, W.-S. Chae, S. Fukuzumi, G.-J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

2010 (5)

M. Y. Berezin and S. Achilefu, “Fluorescence lifetime measurements and biological imaging,” Chem. Rev. 110(5), 2641–2684 (2010).
[Crossref] [PubMed]

Z. Q. Chen, Z. Q. Bian, and C. H. Huang, “Functional IrIII complexes and their applications,” Adv. Mater. 22(13), 1534–1539 (2010).
[Crossref] [PubMed]

Q. Zhao, F. Li, and C. Huang, “Phosphorescent chemosensors based on heavy-metal complexes,” Chem. Soc. Rev. 39(8), 3007–3030 (2010).
[Crossref] [PubMed]

C. Wu, H. F. Chen, K. T. Wong, and M. E. Thompson, “Study of ion-paired iridium complexes (soft salts) and their application in organic light emitting diodes,” J. Am. Chem. Soc. 132(9), 3133–3139 (2010).
[Crossref] [PubMed]

M. Mauro, K. C. Schuermann, R. Prétôt, A. Hafner, P. Mercandelli, A. Sironi, and L. De Cola, “Complex iridium(III) salts: luminescent porous crystalline materials,” Angew. Chem. Int. Ed. Engl. 49(7), 1222–1226 (2010).
[Crossref] [PubMed]

2009 (1)

W. Y. Wong and C. L. Ho, “Heavy metal organometallic electrophosphors derived from multi-component chromophores,” Coord. Chem. Rev. 253(13), 1709–1758 (2009).
[Crossref]

2008 (2)

S. W. Botchway, M. Charnley, J. W. Haycock, A. W. Parker, D. L. Rochester, J. A. Weinstein, and J. A. G. Williams, “Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes,” Proc. Natl. Acad. Sci. U.S.A. 105(42), 16071–16076 (2008).
[Crossref] [PubMed]

H. C. Su, H. F. Chen, F. C. Fang, C. C. Liu, C. C. Wu, K. T. Wong, Y. H. Liu, and S. M. Peng, “Solid-state white light-emitting electrochemical cells using iridium-based cationic transition metal complexes,” J. Am. Chem. Soc. 130(11), 3413–3419 (2008).
[Crossref] [PubMed]

2007 (1)

P. T. Chou and Y. Chi, “Phosphorescent dyes for organic light-emitting diodes,” Chemistry 13(2), 380–395 (2007).
[Crossref] [PubMed]

2005 (1)

Y. You and S. Y. Park, “Inter-ligand energy transfer and related emission change in the cyclometalated heteroleptic iridium complex: facile and efficient color tuning over the whole visible range by the ancillary ligand structure,” J. Am. Chem. Soc. 127(36), 12438–12439 (2005).
[Crossref] [PubMed]

2003 (1)

E. A. Jares-Erijman and T. M. Jovin, “FRET imaging,” Nat. Biotechnol. 21(11), 1387–1395 (2003).
[Crossref] [PubMed]

1997 (1)

A. P. de Silva, H. Q. N. Gunaratne, T. Gunnlaugsson, A. J. M. Huxley, C. P. McCoy, J. T. Rademacher, and T. E. Rice, “Signaling Recognition Events with Fluorescent Sensors and Switches,” Chem. Rev. 97(5), 1515–1566 (1997).
[Crossref] [PubMed]

1996 (1)

R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47(1), 555–606 (1996).
[Crossref] [PubMed]

Accorsi, G.

R. D. Costa, E. Ortí, H. J. Bolink, F. Monti, G. Accorsi, and N. Armaroli, “Luminescent ionic transition-metal complexes for light-emitting electrochemical cells,” Angew. Chem. Int. Ed. Engl. 51(33), 8178–8211 (2012).
[Crossref] [PubMed]

Achilefu, S.

M. Y. Berezin and S. Achilefu, “Fluorescence lifetime measurements and biological imaging,” Chem. Rev. 110(5), 2641–2684 (2010).
[Crossref] [PubMed]

Aigner, D.

D. Aigner, R. I. Dmitriev, S. M. Borisov, D. B. Papkovsky, and I. Klimant, “pH-sensitive perylene bisimide probes for live cell fluorescence lifetime imaging,” J. Mater. Chem. B Mater. Biol. Med. 2(39), 6792–6801 (2014).
[Crossref]

Anglin, E.

L. Gu, D. J. Hall, Z. Qin, E. Anglin, J. Joo, D. J. Mooney, S. B. Howell, and M. J. Sailor, “In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles,” Nat. Commun. 4, 2326 (2013).
[Crossref] [PubMed]

Armaroli, N.

R. D. Costa, E. Ortí, H. J. Bolink, F. Monti, G. Accorsi, and N. Armaroli, “Luminescent ionic transition-metal complexes for light-emitting electrochemical cells,” Angew. Chem. Int. Ed. Engl. 51(33), 8178–8211 (2012).
[Crossref] [PubMed]

Baggaley, E.

E. Baggaley, M. R. Gill, N. H. Green, D. Turton, I. V. Sazanovich, S. W. Botchway, C. Smythe, J. W. Haycock, J. A. Weinstein, and J. A. Thomas, “Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA,” Angew. Chem. Int. Ed. Engl. 53(13), 3367–3371 (2014).
[Crossref] [PubMed]

Baklaushev, V. P.

R. I. Dmitriev, S. M. Borisov, H. Düssmann, S. Sun, B. J. Müller, J. Prehn, V. P. Baklaushev, I. Klimant, and D. B. Papkovsky, “Versatile conjugated polymer nanoparticles for high-resolution O2 Imaging in cells and 3D tissue models,” ACS Nano 9(5), 5275–5288 (2015).
[Crossref] [PubMed]

Beouch, L.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

Berezin, M. Y.

M. Y. Berezin and S. Achilefu, “Fluorescence lifetime measurements and biological imaging,” Chem. Rev. 110(5), 2641–2684 (2010).
[Crossref] [PubMed]

Bertin, D.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

Bian, Z. Q.

Z. Q. Chen, Z. Q. Bian, and C. H. Huang, “Functional IrIII complexes and their applications,” Adv. Mater. 22(13), 1534–1539 (2010).
[Crossref] [PubMed]

Bolink, H. J.

R. D. Costa, E. Ortí, H. J. Bolink, F. Monti, G. Accorsi, and N. Armaroli, “Luminescent ionic transition-metal complexes for light-emitting electrochemical cells,” Angew. Chem. Int. Ed. Engl. 51(33), 8178–8211 (2012).
[Crossref] [PubMed]

W. J. Xu, S. J. Liu, T. C. Ma, Q. Zhao, A. Pertegas, D. Tordera, H. J. Bolink, S. H. Ye, X. M. Liu, S. Sun, and W. Huang, “p–n Metallophosphor based on cationic iridium(III) complex for solid-state light-emitting electrochemical cells,” J. Mater. Chem. 21(36), 13999–14007 (2011).
[Crossref]

Borisov, S. M.

R. I. Dmitriev, S. M. Borisov, H. Düssmann, S. Sun, B. J. Müller, J. Prehn, V. P. Baklaushev, I. Klimant, and D. B. Papkovsky, “Versatile conjugated polymer nanoparticles for high-resolution O2 Imaging in cells and 3D tissue models,” ACS Nano 9(5), 5275–5288 (2015).
[Crossref] [PubMed]

D. Aigner, R. I. Dmitriev, S. M. Borisov, D. B. Papkovsky, and I. Klimant, “pH-sensitive perylene bisimide probes for live cell fluorescence lifetime imaging,” J. Mater. Chem. B Mater. Biol. Med. 2(39), 6792–6801 (2014).
[Crossref]

Botchway, S. W.

E. Baggaley, M. R. Gill, N. H. Green, D. Turton, I. V. Sazanovich, S. W. Botchway, C. Smythe, J. W. Haycock, J. A. Weinstein, and J. A. Thomas, “Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA,” Angew. Chem. Int. Ed. Engl. 53(13), 3367–3371 (2014).
[Crossref] [PubMed]

S. W. Botchway, M. Charnley, J. W. Haycock, A. W. Parker, D. L. Rochester, J. A. Weinstein, and J. A. G. Williams, “Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes,” Proc. Natl. Acad. Sci. U.S.A. 105(42), 16071–16076 (2008).
[Crossref] [PubMed]

Cao, T. Y.

Q. Zhao, X. B. Zhou, T. Y. Cao, K. Y. Zhang, L. J. Yang, S. J. Liu, H. Liang, H. R. Yang, F. Y. Li, and W. Huang, “Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging,” Chem. Sci. (Camb.) 6(3), 1825–1831 (2015).
[Crossref]

Cao, Y.

L. Ying, C. L. Ho, H. Wu, Y. Cao, and W. Y. Wong, “White polymer light-emitting devices for solid-state lighting: materials, devices, and recent progress,” Adv. Mater. 26(16), 2459–2473 (2014).
[Crossref] [PubMed]

Chae, W. S.

Y. You, S. Lee, T. Kim, K. Ohkubo, W. S. Chae, S. Fukuzumi, G. J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Chae, W.-S.

Y. You, S. Lee, T. Kim, K. Ohkubo, W.-S. Chae, S. Fukuzumi, G.-J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Chan, D. S. H.

D. L. Ma, D. S. H. Chan, and C. H. Leung, “Group 9 organometallic compounds for therapeutic and bioanalytical applications,” Acc. Chem. Res. 47(12), 3614–3631 (2014).
[Crossref] [PubMed]

Charnley, M.

S. W. Botchway, M. Charnley, J. W. Haycock, A. W. Parker, D. L. Rochester, J. A. Weinstein, and J. A. G. Williams, “Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes,” Proc. Natl. Acad. Sci. U.S.A. 105(42), 16071–16076 (2008).
[Crossref] [PubMed]

Chen, H. F.

C. Wu, H. F. Chen, K. T. Wong, and M. E. Thompson, “Study of ion-paired iridium complexes (soft salts) and their application in organic light emitting diodes,” J. Am. Chem. Soc. 132(9), 3133–3139 (2010).
[Crossref] [PubMed]

H. C. Su, H. F. Chen, F. C. Fang, C. C. Liu, C. C. Wu, K. T. Wong, Y. H. Liu, and S. M. Peng, “Solid-state white light-emitting electrochemical cells using iridium-based cationic transition metal complexes,” J. Am. Chem. Soc. 130(11), 3413–3419 (2008).
[Crossref] [PubMed]

Chen, Z. Q.

Z. Q. Chen, Z. Q. Bian, and C. H. Huang, “Functional IrIII complexes and their applications,” Adv. Mater. 22(13), 1534–1539 (2010).
[Crossref] [PubMed]

Chi, Y.

P. T. Chou and Y. Chi, “Phosphorescent dyes for organic light-emitting diodes,” Chemistry 13(2), 380–395 (2007).
[Crossref] [PubMed]

Chou, P. T.

P. T. Chou and Y. Chi, “Phosphorescent dyes for organic light-emitting diodes,” Chemistry 13(2), 380–395 (2007).
[Crossref] [PubMed]

Clavier, G.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

Costa, R. D.

R. D. Costa, E. Ortí, H. J. Bolink, F. Monti, G. Accorsi, and N. Armaroli, “Luminescent ionic transition-metal complexes for light-emitting electrochemical cells,” Angew. Chem. Int. Ed. Engl. 51(33), 8178–8211 (2012).
[Crossref] [PubMed]

De Cola, L.

M. Mauro, K. C. Schuermann, R. Prétôt, A. Hafner, P. Mercandelli, A. Sironi, and L. De Cola, “Complex iridium(III) salts: luminescent porous crystalline materials,” Angew. Chem. Int. Ed. Engl. 49(7), 1222–1226 (2010).
[Crossref] [PubMed]

de Silva, A. P.

A. P. de Silva, H. Q. N. Gunaratne, T. Gunnlaugsson, A. J. M. Huxley, C. P. McCoy, J. T. Rademacher, and T. E. Rice, “Signaling Recognition Events with Fluorescent Sensors and Switches,” Chem. Rev. 97(5), 1515–1566 (1997).
[Crossref] [PubMed]

Dmitriev, R. I.

R. I. Dmitriev, S. M. Borisov, H. Düssmann, S. Sun, B. J. Müller, J. Prehn, V. P. Baklaushev, I. Klimant, and D. B. Papkovsky, “Versatile conjugated polymer nanoparticles for high-resolution O2 Imaging in cells and 3D tissue models,” ACS Nano 9(5), 5275–5288 (2015).
[Crossref] [PubMed]

D. Aigner, R. I. Dmitriev, S. M. Borisov, D. B. Papkovsky, and I. Klimant, “pH-sensitive perylene bisimide probes for live cell fluorescence lifetime imaging,” J. Mater. Chem. B Mater. Biol. Med. 2(39), 6792–6801 (2014).
[Crossref]

Dumas, E.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

Dumur, F.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

Düssmann, H.

R. I. Dmitriev, S. M. Borisov, H. Düssmann, S. Sun, B. J. Müller, J. Prehn, V. P. Baklaushev, I. Klimant, and D. B. Papkovsky, “Versatile conjugated polymer nanoparticles for high-resolution O2 Imaging in cells and 3D tissue models,” ACS Nano 9(5), 5275–5288 (2015).
[Crossref] [PubMed]

Fang, F. C.

H. C. Su, H. F. Chen, F. C. Fang, C. C. Liu, C. C. Wu, K. T. Wong, Y. H. Liu, and S. M. Peng, “Solid-state white light-emitting electrochemical cells using iridium-based cationic transition metal complexes,” J. Am. Chem. Soc. 130(11), 3413–3419 (2008).
[Crossref] [PubMed]

Fukuzumi, S.

Y. You, S. Lee, T. Kim, K. Ohkubo, W. S. Chae, S. Fukuzumi, G. J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Y. You, S. Lee, T. Kim, K. Ohkubo, W.-S. Chae, S. Fukuzumi, G.-J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Ghedini, M.

A. Ionescu, E. I. Szerb, Y. J. Yadav, A. M. Talarico, M. Ghedini, and N. Godbert, “Orotate containing anionic luminescent iridium(III) complexes and their use in soft salts,” Dalton Trans. 43(2), 784–789 (2014).
[Crossref] [PubMed]

Gigmes, D.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

Gill, M. R.

E. Baggaley, M. R. Gill, N. H. Green, D. Turton, I. V. Sazanovich, S. W. Botchway, C. Smythe, J. W. Haycock, J. A. Weinstein, and J. A. Thomas, “Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA,” Angew. Chem. Int. Ed. Engl. 53(13), 3367–3371 (2014).
[Crossref] [PubMed]

Godbert, N.

A. Ionescu, E. I. Szerb, Y. J. Yadav, A. M. Talarico, M. Ghedini, and N. Godbert, “Orotate containing anionic luminescent iridium(III) complexes and their use in soft salts,” Dalton Trans. 43(2), 784–789 (2014).
[Crossref] [PubMed]

Goubard, F.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

Green, N. H.

E. Baggaley, M. R. Gill, N. H. Green, D. Turton, I. V. Sazanovich, S. W. Botchway, C. Smythe, J. W. Haycock, J. A. Weinstein, and J. A. Thomas, “Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA,” Angew. Chem. Int. Ed. Engl. 53(13), 3367–3371 (2014).
[Crossref] [PubMed]

Gu, L.

L. Gu, D. J. Hall, Z. Qin, E. Anglin, J. Joo, D. J. Mooney, S. B. Howell, and M. J. Sailor, “In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles,” Nat. Commun. 4, 2326 (2013).
[Crossref] [PubMed]

Guerlin, A.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

Gunaratne, H. Q. N.

A. P. de Silva, H. Q. N. Gunaratne, T. Gunnlaugsson, A. J. M. Huxley, C. P. McCoy, J. T. Rademacher, and T. E. Rice, “Signaling Recognition Events with Fluorescent Sensors and Switches,” Chem. Rev. 97(5), 1515–1566 (1997).
[Crossref] [PubMed]

Gunnlaugsson, T.

A. P. de Silva, H. Q. N. Gunaratne, T. Gunnlaugsson, A. J. M. Huxley, C. P. McCoy, J. T. Rademacher, and T. E. Rice, “Signaling Recognition Events with Fluorescent Sensors and Switches,” Chem. Rev. 97(5), 1515–1566 (1997).
[Crossref] [PubMed]

Guo, S.

P. Tao, W. L. Li, J. Zhang, S. Guo, Q. Zhao, H. Wang, B. Wei, S. J. Liu, X. H. Zhou, Q. Yu, B. S. Xu, and W. Huang, “Facile synthesis of highly efficient lepidine-based phosphorescent iridium(III) complexes for yellow and white organic light-emitting diodes,” Adv. Funct. Mater. 26(6), 881–894 (2016).
[Crossref]

S. Guo, T. Huang, S. Liu, K. Y. Zhang, H. Yang, J. Han, Q. Zhao, and W. Huang, “Luminescent ion pairs with tunable emission colors for light-emitting devices and electrochromic switches,” Chem. Sci. (Camb.) (2016), doi:.
[Crossref]

Hafner, A.

M. Mauro, K. C. Schuermann, R. Prétôt, A. Hafner, P. Mercandelli, A. Sironi, and L. De Cola, “Complex iridium(III) salts: luminescent porous crystalline materials,” Angew. Chem. Int. Ed. Engl. 49(7), 1222–1226 (2010).
[Crossref] [PubMed]

Hall, D. J.

L. Gu, D. J. Hall, Z. Qin, E. Anglin, J. Joo, D. J. Mooney, S. B. Howell, and M. J. Sailor, “In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles,” Nat. Commun. 4, 2326 (2013).
[Crossref] [PubMed]

Han, J.

S. Guo, T. Huang, S. Liu, K. Y. Zhang, H. Yang, J. Han, Q. Zhao, and W. Huang, “Luminescent ion pairs with tunable emission colors for light-emitting devices and electrochromic switches,” Chem. Sci. (Camb.) (2016), doi:.
[Crossref]

Han, J. H.

M. H. Lee, J. H. Han, J. H. Lee, N. Park, R. Kumar, C. Kang, and J. S. Kim, “Two-color probe to monitor a wide range of pH values in cells,” Angew. Chem. Int. Ed. Engl. 52(24), 6206–6209 (2013).
[Crossref] [PubMed]

Haycock, J. W.

E. Baggaley, M. R. Gill, N. H. Green, D. Turton, I. V. Sazanovich, S. W. Botchway, C. Smythe, J. W. Haycock, J. A. Weinstein, and J. A. Thomas, “Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA,” Angew. Chem. Int. Ed. Engl. 53(13), 3367–3371 (2014).
[Crossref] [PubMed]

S. W. Botchway, M. Charnley, J. W. Haycock, A. W. Parker, D. L. Rochester, J. A. Weinstein, and J. A. G. Williams, “Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes,” Proc. Natl. Acad. Sci. U.S.A. 105(42), 16071–16076 (2008).
[Crossref] [PubMed]

He, B.

K. H. Leung, H. Z. He, B. He, H. J. Zhong, S. Lin, Y. T. Wang, D. L. Ma, and C. H. Leung, “Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe,” Chem. Sci. (Camb.) 6(4), 2166–2171 (2015).
[Crossref]

He, H. Z.

K. H. Leung, H. Z. He, B. He, H. J. Zhong, S. Lin, Y. T. Wang, D. L. Ma, and C. H. Leung, “Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe,” Chem. Sci. (Camb.) 6(4), 2166–2171 (2015).
[Crossref]

Ho, C. L.

Y. Ma, H. Liang, Y. Zeng, H. R. Yang, C. L. Ho, W. J. Xu, Q. Zhao, W. Huang, and W. Y. Wong, “Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations,” Chem. Sci. (Camb.) 7(5), 3338–3346 (2016).
[Crossref]

L. Ying, C. L. Ho, H. Wu, Y. Cao, and W. Y. Wong, “White polymer light-emitting devices for solid-state lighting: materials, devices, and recent progress,” Adv. Mater. 26(16), 2459–2473 (2014).
[Crossref] [PubMed]

W. Y. Wong and C. L. Ho, “Heavy metal organometallic electrophosphors derived from multi-component chromophores,” Coord. Chem. Rev. 253(13), 1709–1758 (2009).
[Crossref]

Howell, S. B.

L. Gu, D. J. Hall, Z. Qin, E. Anglin, J. Joo, D. J. Mooney, S. B. Howell, and M. J. Sailor, “In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles,” Nat. Commun. 4, 2326 (2013).
[Crossref] [PubMed]

Huang, C.

Q. Zhao, F. Li, and C. Huang, “Phosphorescent chemosensors based on heavy-metal complexes,” Chem. Soc. Rev. 39(8), 3007–3030 (2010).
[Crossref] [PubMed]

Huang, C. H.

Z. Q. Chen, Z. Q. Bian, and C. H. Huang, “Functional IrIII complexes and their applications,” Adv. Mater. 22(13), 1534–1539 (2010).
[Crossref] [PubMed]

Huang, T.

S. Guo, T. Huang, S. Liu, K. Y. Zhang, H. Yang, J. Han, Q. Zhao, and W. Huang, “Luminescent ion pairs with tunable emission colors for light-emitting devices and electrochromic switches,” Chem. Sci. (Camb.) (2016), doi:.
[Crossref]

Huang, W.

Y. Ma, H. Liang, Y. Zeng, H. R. Yang, C. L. Ho, W. J. Xu, Q. Zhao, W. Huang, and W. Y. Wong, “Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations,” Chem. Sci. (Camb.) 7(5), 3338–3346 (2016).
[Crossref]

P. Tao, W. L. Li, J. Zhang, S. Guo, Q. Zhao, H. Wang, B. Wei, S. J. Liu, X. H. Zhou, Q. Yu, B. S. Xu, and W. Huang, “Facile synthesis of highly efficient lepidine-based phosphorescent iridium(III) complexes for yellow and white organic light-emitting diodes,” Adv. Funct. Mater. 26(6), 881–894 (2016).
[Crossref]

S. Liu, H. Liang, K. Y. Zhang, Q. Zhao, X. Zhou, W. Xu, and W. Huang, “A multifunctional phosphorescent iridium(III) complex for specific nucleus staining and hypoxia monitoring,” Chem. Commun. (Camb.) 51(37), 7943–7946 (2015).
[Crossref] [PubMed]

K. Y. Zhang, J. Zhang, Y. Liu, S. Liu, P. Zhang, Q. Zhao, Y. Tang, and W. Huang, “Core–shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy,” Chem. Sci. (Camb.) 6(1), 301–307 (2015).
[Crossref]

S. Liu, J. Zhang, D. Shen, H. Liang, X. Liu, Q. Zhao, and W. Huang, “Reaction-based phosphorescent nanosensor for ratiometric and time-resolved luminescence imaging of fluoride in live cells,” Chem. Commun. (Camb.) 51(64), 12839–12842 (2015).
[Crossref] [PubMed]

Q. Zhao, X. B. Zhou, T. Y. Cao, K. Y. Zhang, L. J. Yang, S. J. Liu, H. Liang, H. R. Yang, F. Y. Li, and W. Huang, “Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging,” Chem. Sci. (Camb.) 6(3), 1825–1831 (2015).
[Crossref]

W. Xu, X. Zhao, W. Lv, H. Yang, S. Liu, H. Liang, Z. Tu, H. Xu, W. Qiao, Q. Zhao, and W. Huang, “Rational design of phosphorescent chemodosimeter for reaction-based one- and two-photon and time-resolved luminescent imaging of biothiols in living cells,” Adv. Healthc. Mater. 3(5), 658–669 (2014).
[Crossref] [PubMed]

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
[Crossref] [PubMed]

C. Shi, H. Sun, X. Tang, W. Lv, H. Yan, Q. Zhao, J. Wang, and W. Huang, “Variable photophysical properties of phosphorescent iridium(III) complexes triggered by closo- and nido-carborane substitution,” Angew. Chem. Int. Ed. Engl. 52(50), 13434–13438 (2013).
[Crossref] [PubMed]

W. J. Xu, S. J. Liu, T. C. Ma, Q. Zhao, A. Pertegas, D. Tordera, H. J. Bolink, S. H. Ye, X. M. Liu, S. Sun, and W. Huang, “p–n Metallophosphor based on cationic iridium(III) complex for solid-state light-emitting electrochemical cells,” J. Mater. Chem. 21(36), 13999–14007 (2011).
[Crossref]

Y. Ma, S. J. Liu, H. R. Yang, Y. Q. Wu, C. J. Yang, X. M. Liu, Q. Zhao, H. Z. Wu, J. C. Liang, F. Y. Li, and W. Huang, “Water-soluble phosphorescent iridium(III) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells,” J. Mater. Chem. 21(47), 18974–18982 (2011).
[Crossref]

S. Guo, T. Huang, S. Liu, K. Y. Zhang, H. Yang, J. Han, Q. Zhao, and W. Huang, “Luminescent ion pairs with tunable emission colors for light-emitting devices and electrochromic switches,” Chem. Sci. (Camb.) (2016), doi:.
[Crossref]

Huang, X.

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
[Crossref] [PubMed]

Huo, F.

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
[Crossref] [PubMed]

Huxley, A. J. M.

A. P. de Silva, H. Q. N. Gunaratne, T. Gunnlaugsson, A. J. M. Huxley, C. P. McCoy, J. T. Rademacher, and T. E. Rice, “Signaling Recognition Events with Fluorescent Sensors and Switches,” Chem. Rev. 97(5), 1515–1566 (1997).
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Ionescu, A.

A. Ionescu, E. I. Szerb, Y. J. Yadav, A. M. Talarico, M. Ghedini, and N. Godbert, “Orotate containing anionic luminescent iridium(III) complexes and their use in soft salts,” Dalton Trans. 43(2), 784–789 (2014).
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Jares-Erijman, E. A.

E. A. Jares-Erijman and T. M. Jovin, “FRET imaging,” Nat. Biotechnol. 21(11), 1387–1395 (2003).
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Jenkins, G.

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
[Crossref] [PubMed]

Jhon, G. J.

Y. You, S. Lee, T. Kim, K. Ohkubo, W. S. Chae, S. Fukuzumi, G. J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Jhon, G.-J.

Y. You, S. Lee, T. Kim, K. Ohkubo, W.-S. Chae, S. Fukuzumi, G.-J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Joo, J.

L. Gu, D. J. Hall, Z. Qin, E. Anglin, J. Joo, D. J. Mooney, S. B. Howell, and M. J. Sailor, “In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles,” Nat. Commun. 4, 2326 (2013).
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Jovin, T. M.

E. A. Jares-Erijman and T. M. Jovin, “FRET imaging,” Nat. Biotechnol. 21(11), 1387–1395 (2003).
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Kang, C.

M. H. Lee, J. H. Han, J. H. Lee, N. Park, R. Kumar, C. Kang, and J. S. Kim, “Two-color probe to monitor a wide range of pH values in cells,” Angew. Chem. Int. Ed. Engl. 52(24), 6206–6209 (2013).
[Crossref] [PubMed]

Kim, J. S.

M. H. Lee, J. S. Kim, and J. L. Sessler, “Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules,” Chem. Soc. Rev. 44(13), 4185–4191 (2015).
[Crossref] [PubMed]

M. H. Lee, J. H. Han, J. H. Lee, N. Park, R. Kumar, C. Kang, and J. S. Kim, “Two-color probe to monitor a wide range of pH values in cells,” Angew. Chem. Int. Ed. Engl. 52(24), 6206–6209 (2013).
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Kim, T.

Y. You, S. Lee, T. Kim, K. Ohkubo, W.-S. Chae, S. Fukuzumi, G.-J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
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Y. You, S. Lee, T. Kim, K. Ohkubo, W. S. Chae, S. Fukuzumi, G. J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Klimant, I.

R. I. Dmitriev, S. M. Borisov, H. Düssmann, S. Sun, B. J. Müller, J. Prehn, V. P. Baklaushev, I. Klimant, and D. B. Papkovsky, “Versatile conjugated polymer nanoparticles for high-resolution O2 Imaging in cells and 3D tissue models,” ACS Nano 9(5), 5275–5288 (2015).
[Crossref] [PubMed]

D. Aigner, R. I. Dmitriev, S. M. Borisov, D. B. Papkovsky, and I. Klimant, “pH-sensitive perylene bisimide probes for live cell fluorescence lifetime imaging,” J. Mater. Chem. B Mater. Biol. Med. 2(39), 6792–6801 (2014).
[Crossref]

Kumar, R.

M. H. Lee, J. H. Han, J. H. Lee, N. Park, R. Kumar, C. Kang, and J. S. Kim, “Two-color probe to monitor a wide range of pH values in cells,” Angew. Chem. Int. Ed. Engl. 52(24), 6206–6209 (2013).
[Crossref] [PubMed]

Lee, J. H.

M. H. Lee, J. H. Han, J. H. Lee, N. Park, R. Kumar, C. Kang, and J. S. Kim, “Two-color probe to monitor a wide range of pH values in cells,” Angew. Chem. Int. Ed. Engl. 52(24), 6206–6209 (2013).
[Crossref] [PubMed]

Lee, M. H.

M. H. Lee, J. S. Kim, and J. L. Sessler, “Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules,” Chem. Soc. Rev. 44(13), 4185–4191 (2015).
[Crossref] [PubMed]

M. H. Lee, J. H. Han, J. H. Lee, N. Park, R. Kumar, C. Kang, and J. S. Kim, “Two-color probe to monitor a wide range of pH values in cells,” Angew. Chem. Int. Ed. Engl. 52(24), 6206–6209 (2013).
[Crossref] [PubMed]

Lee, S.

Y. You, S. Lee, T. Kim, K. Ohkubo, W.-S. Chae, S. Fukuzumi, G.-J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Y. You, S. Lee, T. Kim, K. Ohkubo, W. S. Chae, S. Fukuzumi, G. J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Lee, S. M. Y.

Z. Mao, M. Wang, J. Liu, L. J. Liu, S. M. Y. Lee, C. H. Leung, and D. L. Ma, “A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish,” Chem. Commun. (Camb.) 52(24), 4450–4453 (2016).
[Crossref] [PubMed]

Leung, C. H.

Z. Mao, M. Wang, J. Liu, L. J. Liu, S. M. Y. Lee, C. H. Leung, and D. L. Ma, “A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish,” Chem. Commun. (Camb.) 52(24), 4450–4453 (2016).
[Crossref] [PubMed]

K. H. Leung, H. Z. He, B. He, H. J. Zhong, S. Lin, Y. T. Wang, D. L. Ma, and C. H. Leung, “Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe,” Chem. Sci. (Camb.) 6(4), 2166–2171 (2015).
[Crossref]

D. L. Ma, D. S. H. Chan, and C. H. Leung, “Group 9 organometallic compounds for therapeutic and bioanalytical applications,” Acc. Chem. Res. 47(12), 3614–3631 (2014).
[Crossref] [PubMed]

Leung, K. H.

K. H. Leung, H. Z. He, B. He, H. J. Zhong, S. Lin, Y. T. Wang, D. L. Ma, and C. H. Leung, “Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe,” Chem. Sci. (Camb.) 6(4), 2166–2171 (2015).
[Crossref]

Li, F.

Q. Zhao, F. Li, and C. Huang, “Phosphorescent chemosensors based on heavy-metal complexes,” Chem. Soc. Rev. 39(8), 3007–3030 (2010).
[Crossref] [PubMed]

Li, F. Y.

Q. Zhao, X. B. Zhou, T. Y. Cao, K. Y. Zhang, L. J. Yang, S. J. Liu, H. Liang, H. R. Yang, F. Y. Li, and W. Huang, “Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging,” Chem. Sci. (Camb.) 6(3), 1825–1831 (2015).
[Crossref]

Y. Ma, S. J. Liu, H. R. Yang, Y. Q. Wu, C. J. Yang, X. M. Liu, Q. Zhao, H. Z. Wu, J. C. Liang, F. Y. Li, and W. Huang, “Water-soluble phosphorescent iridium(III) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells,” J. Mater. Chem. 21(47), 18974–18982 (2011).
[Crossref]

Li, W. L.

P. Tao, W. L. Li, J. Zhang, S. Guo, Q. Zhao, H. Wang, B. Wei, S. J. Liu, X. H. Zhou, Q. Yu, B. S. Xu, and W. Huang, “Facile synthesis of highly efficient lepidine-based phosphorescent iridium(III) complexes for yellow and white organic light-emitting diodes,” Adv. Funct. Mater. 26(6), 881–894 (2016).
[Crossref]

Liang, H.

Y. Ma, H. Liang, Y. Zeng, H. R. Yang, C. L. Ho, W. J. Xu, Q. Zhao, W. Huang, and W. Y. Wong, “Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations,” Chem. Sci. (Camb.) 7(5), 3338–3346 (2016).
[Crossref]

S. Liu, J. Zhang, D. Shen, H. Liang, X. Liu, Q. Zhao, and W. Huang, “Reaction-based phosphorescent nanosensor for ratiometric and time-resolved luminescence imaging of fluoride in live cells,” Chem. Commun. (Camb.) 51(64), 12839–12842 (2015).
[Crossref] [PubMed]

S. Liu, H. Liang, K. Y. Zhang, Q. Zhao, X. Zhou, W. Xu, and W. Huang, “A multifunctional phosphorescent iridium(III) complex for specific nucleus staining and hypoxia monitoring,” Chem. Commun. (Camb.) 51(37), 7943–7946 (2015).
[Crossref] [PubMed]

Q. Zhao, X. B. Zhou, T. Y. Cao, K. Y. Zhang, L. J. Yang, S. J. Liu, H. Liang, H. R. Yang, F. Y. Li, and W. Huang, “Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging,” Chem. Sci. (Camb.) 6(3), 1825–1831 (2015).
[Crossref]

W. Xu, X. Zhao, W. Lv, H. Yang, S. Liu, H. Liang, Z. Tu, H. Xu, W. Qiao, Q. Zhao, and W. Huang, “Rational design of phosphorescent chemodosimeter for reaction-based one- and two-photon and time-resolved luminescent imaging of biothiols in living cells,” Adv. Healthc. Mater. 3(5), 658–669 (2014).
[Crossref] [PubMed]

Liang, J. C.

Y. Ma, S. J. Liu, H. R. Yang, Y. Q. Wu, C. J. Yang, X. M. Liu, Q. Zhao, H. Z. Wu, J. C. Liang, F. Y. Li, and W. Huang, “Water-soluble phosphorescent iridium(III) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells,” J. Mater. Chem. 21(47), 18974–18982 (2011).
[Crossref]

Lin, S.

K. H. Leung, H. Z. He, B. He, H. J. Zhong, S. Lin, Y. T. Wang, D. L. Ma, and C. H. Leung, “Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe,” Chem. Sci. (Camb.) 6(4), 2166–2171 (2015).
[Crossref]

Lin, W.

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
[Crossref] [PubMed]

Lippard, S. J.

Y. You, S. Lee, T. Kim, K. Ohkubo, W. S. Chae, S. Fukuzumi, G. J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Y. You, S. Lee, T. Kim, K. Ohkubo, W.-S. Chae, S. Fukuzumi, G.-J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Liu, C. C.

H. C. Su, H. F. Chen, F. C. Fang, C. C. Liu, C. C. Wu, K. T. Wong, Y. H. Liu, and S. M. Peng, “Solid-state white light-emitting electrochemical cells using iridium-based cationic transition metal complexes,” J. Am. Chem. Soc. 130(11), 3413–3419 (2008).
[Crossref] [PubMed]

Liu, J.

Z. Mao, M. Wang, J. Liu, L. J. Liu, S. M. Y. Lee, C. H. Leung, and D. L. Ma, “A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish,” Chem. Commun. (Camb.) 52(24), 4450–4453 (2016).
[Crossref] [PubMed]

Liu, L. J.

Z. Mao, M. Wang, J. Liu, L. J. Liu, S. M. Y. Lee, C. H. Leung, and D. L. Ma, “A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish,” Chem. Commun. (Camb.) 52(24), 4450–4453 (2016).
[Crossref] [PubMed]

Liu, S.

S. Liu, H. Liang, K. Y. Zhang, Q. Zhao, X. Zhou, W. Xu, and W. Huang, “A multifunctional phosphorescent iridium(III) complex for specific nucleus staining and hypoxia monitoring,” Chem. Commun. (Camb.) 51(37), 7943–7946 (2015).
[Crossref] [PubMed]

K. Y. Zhang, J. Zhang, Y. Liu, S. Liu, P. Zhang, Q. Zhao, Y. Tang, and W. Huang, “Core–shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy,” Chem. Sci. (Camb.) 6(1), 301–307 (2015).
[Crossref]

S. Liu, J. Zhang, D. Shen, H. Liang, X. Liu, Q. Zhao, and W. Huang, “Reaction-based phosphorescent nanosensor for ratiometric and time-resolved luminescence imaging of fluoride in live cells,” Chem. Commun. (Camb.) 51(64), 12839–12842 (2015).
[Crossref] [PubMed]

W. Xu, X. Zhao, W. Lv, H. Yang, S. Liu, H. Liang, Z. Tu, H. Xu, W. Qiao, Q. Zhao, and W. Huang, “Rational design of phosphorescent chemodosimeter for reaction-based one- and two-photon and time-resolved luminescent imaging of biothiols in living cells,” Adv. Healthc. Mater. 3(5), 658–669 (2014).
[Crossref] [PubMed]

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
[Crossref] [PubMed]

S. Guo, T. Huang, S. Liu, K. Y. Zhang, H. Yang, J. Han, Q. Zhao, and W. Huang, “Luminescent ion pairs with tunable emission colors for light-emitting devices and electrochromic switches,” Chem. Sci. (Camb.) (2016), doi:.
[Crossref]

Liu, S. J.

P. Tao, W. L. Li, J. Zhang, S. Guo, Q. Zhao, H. Wang, B. Wei, S. J. Liu, X. H. Zhou, Q. Yu, B. S. Xu, and W. Huang, “Facile synthesis of highly efficient lepidine-based phosphorescent iridium(III) complexes for yellow and white organic light-emitting diodes,” Adv. Funct. Mater. 26(6), 881–894 (2016).
[Crossref]

Q. Zhao, X. B. Zhou, T. Y. Cao, K. Y. Zhang, L. J. Yang, S. J. Liu, H. Liang, H. R. Yang, F. Y. Li, and W. Huang, “Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging,” Chem. Sci. (Camb.) 6(3), 1825–1831 (2015).
[Crossref]

Y. Ma, S. J. Liu, H. R. Yang, Y. Q. Wu, C. J. Yang, X. M. Liu, Q. Zhao, H. Z. Wu, J. C. Liang, F. Y. Li, and W. Huang, “Water-soluble phosphorescent iridium(III) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells,” J. Mater. Chem. 21(47), 18974–18982 (2011).
[Crossref]

W. J. Xu, S. J. Liu, T. C. Ma, Q. Zhao, A. Pertegas, D. Tordera, H. J. Bolink, S. H. Ye, X. M. Liu, S. Sun, and W. Huang, “p–n Metallophosphor based on cationic iridium(III) complex for solid-state light-emitting electrochemical cells,” J. Mater. Chem. 21(36), 13999–14007 (2011).
[Crossref]

Liu, X.

S. Liu, J. Zhang, D. Shen, H. Liang, X. Liu, Q. Zhao, and W. Huang, “Reaction-based phosphorescent nanosensor for ratiometric and time-resolved luminescence imaging of fluoride in live cells,” Chem. Commun. (Camb.) 51(64), 12839–12842 (2015).
[Crossref] [PubMed]

Liu, X. M.

Y. Ma, S. J. Liu, H. R. Yang, Y. Q. Wu, C. J. Yang, X. M. Liu, Q. Zhao, H. Z. Wu, J. C. Liang, F. Y. Li, and W. Huang, “Water-soluble phosphorescent iridium(III) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells,” J. Mater. Chem. 21(47), 18974–18982 (2011).
[Crossref]

W. J. Xu, S. J. Liu, T. C. Ma, Q. Zhao, A. Pertegas, D. Tordera, H. J. Bolink, S. H. Ye, X. M. Liu, S. Sun, and W. Huang, “p–n Metallophosphor based on cationic iridium(III) complex for solid-state light-emitting electrochemical cells,” J. Mater. Chem. 21(36), 13999–14007 (2011).
[Crossref]

Liu, Y.

K. Y. Zhang, J. Zhang, Y. Liu, S. Liu, P. Zhang, Q. Zhao, Y. Tang, and W. Huang, “Core–shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy,” Chem. Sci. (Camb.) 6(1), 301–307 (2015).
[Crossref]

Liu, Y. H.

H. C. Su, H. F. Chen, F. C. Fang, C. C. Liu, C. C. Wu, K. T. Wong, Y. H. Liu, and S. M. Peng, “Solid-state white light-emitting electrochemical cells using iridium-based cationic transition metal complexes,” J. Am. Chem. Soc. 130(11), 3413–3419 (2008).
[Crossref] [PubMed]

Lv, W.

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
[Crossref] [PubMed]

W. Xu, X. Zhao, W. Lv, H. Yang, S. Liu, H. Liang, Z. Tu, H. Xu, W. Qiao, Q. Zhao, and W. Huang, “Rational design of phosphorescent chemodosimeter for reaction-based one- and two-photon and time-resolved luminescent imaging of biothiols in living cells,” Adv. Healthc. Mater. 3(5), 658–669 (2014).
[Crossref] [PubMed]

C. Shi, H. Sun, X. Tang, W. Lv, H. Yan, Q. Zhao, J. Wang, and W. Huang, “Variable photophysical properties of phosphorescent iridium(III) complexes triggered by closo- and nido-carborane substitution,” Angew. Chem. Int. Ed. Engl. 52(50), 13434–13438 (2013).
[Crossref] [PubMed]

Ma, D. L.

Z. Mao, M. Wang, J. Liu, L. J. Liu, S. M. Y. Lee, C. H. Leung, and D. L. Ma, “A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish,” Chem. Commun. (Camb.) 52(24), 4450–4453 (2016).
[Crossref] [PubMed]

K. H. Leung, H. Z. He, B. He, H. J. Zhong, S. Lin, Y. T. Wang, D. L. Ma, and C. H. Leung, “Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe,” Chem. Sci. (Camb.) 6(4), 2166–2171 (2015).
[Crossref]

D. L. Ma, D. S. H. Chan, and C. H. Leung, “Group 9 organometallic compounds for therapeutic and bioanalytical applications,” Acc. Chem. Res. 47(12), 3614–3631 (2014).
[Crossref] [PubMed]

Ma, T. C.

W. J. Xu, S. J. Liu, T. C. Ma, Q. Zhao, A. Pertegas, D. Tordera, H. J. Bolink, S. H. Ye, X. M. Liu, S. Sun, and W. Huang, “p–n Metallophosphor based on cationic iridium(III) complex for solid-state light-emitting electrochemical cells,” J. Mater. Chem. 21(36), 13999–14007 (2011).
[Crossref]

Ma, Y.

Y. Ma, H. Liang, Y. Zeng, H. R. Yang, C. L. Ho, W. J. Xu, Q. Zhao, W. Huang, and W. Y. Wong, “Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations,” Chem. Sci. (Camb.) 7(5), 3338–3346 (2016).
[Crossref]

Y. Ma, S. J. Liu, H. R. Yang, Y. Q. Wu, C. J. Yang, X. M. Liu, Q. Zhao, H. Z. Wu, J. C. Liang, F. Y. Li, and W. Huang, “Water-soluble phosphorescent iridium(III) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells,” J. Mater. Chem. 21(47), 18974–18982 (2011).
[Crossref]

Mao, Z.

Z. Mao, M. Wang, J. Liu, L. J. Liu, S. M. Y. Lee, C. H. Leung, and D. L. Ma, “A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish,” Chem. Commun. (Camb.) 52(24), 4450–4453 (2016).
[Crossref] [PubMed]

Mauro, M.

M. Mauro, K. C. Schuermann, R. Prétôt, A. Hafner, P. Mercandelli, A. Sironi, and L. De Cola, “Complex iridium(III) salts: luminescent porous crystalline materials,” Angew. Chem. Int. Ed. Engl. 49(7), 1222–1226 (2010).
[Crossref] [PubMed]

Mayer, C. R.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

McCoy, C. P.

A. P. de Silva, H. Q. N. Gunaratne, T. Gunnlaugsson, A. J. M. Huxley, C. P. McCoy, J. T. Rademacher, and T. E. Rice, “Signaling Recognition Events with Fluorescent Sensors and Switches,” Chem. Rev. 97(5), 1515–1566 (1997).
[Crossref] [PubMed]

Mercandelli, P.

M. Mauro, K. C. Schuermann, R. Prétôt, A. Hafner, P. Mercandelli, A. Sironi, and L. De Cola, “Complex iridium(III) salts: luminescent porous crystalline materials,” Angew. Chem. Int. Ed. Engl. 49(7), 1222–1226 (2010).
[Crossref] [PubMed]

Miomandre, F.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

Monti, F.

R. D. Costa, E. Ortí, H. J. Bolink, F. Monti, G. Accorsi, and N. Armaroli, “Luminescent ionic transition-metal complexes for light-emitting electrochemical cells,” Angew. Chem. Int. Ed. Engl. 51(33), 8178–8211 (2012).
[Crossref] [PubMed]

Mooney, D. J.

L. Gu, D. J. Hall, Z. Qin, E. Anglin, J. Joo, D. J. Mooney, S. B. Howell, and M. J. Sailor, “In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles,” Nat. Commun. 4, 2326 (2013).
[Crossref] [PubMed]

Müller, B. J.

R. I. Dmitriev, S. M. Borisov, H. Düssmann, S. Sun, B. J. Müller, J. Prehn, V. P. Baklaushev, I. Klimant, and D. B. Papkovsky, “Versatile conjugated polymer nanoparticles for high-resolution O2 Imaging in cells and 3D tissue models,” ACS Nano 9(5), 5275–5288 (2015).
[Crossref] [PubMed]

Nam, W.

Y. You, S. Lee, T. Kim, K. Ohkubo, W. S. Chae, S. Fukuzumi, G. J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Y. You, S. Lee, T. Kim, K. Ohkubo, W.-S. Chae, S. Fukuzumi, G.-J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Nasr, G.

G. Nasr, A. Guerlin, F. Dumur, L. Beouch, E. Dumas, G. Clavier, F. Miomandre, F. Goubard, D. Gigmes, D. Bertin, G. Wantz, and C. R. Mayer, “Iridium(III) soft salts from dinuclear cationic and mononuclear anionic complexes for OLED devices,” Chem. Commun. (Camb.) 47(38), 10698–10700 (2011).
[Crossref] [PubMed]

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Y. Ma, S. J. Liu, H. R. Yang, Y. Q. Wu, C. J. Yang, X. M. Liu, Q. Zhao, H. Z. Wu, J. C. Liang, F. Y. Li, and W. Huang, “Water-soluble phosphorescent iridium(III) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells,” J. Mater. Chem. 21(47), 18974–18982 (2011).
[Crossref]

Yang, L. J.

Q. Zhao, X. B. Zhou, T. Y. Cao, K. Y. Zhang, L. J. Yang, S. J. Liu, H. Liang, H. R. Yang, F. Y. Li, and W. Huang, “Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging,” Chem. Sci. (Camb.) 6(3), 1825–1831 (2015).
[Crossref]

Ye, S. H.

W. J. Xu, S. J. Liu, T. C. Ma, Q. Zhao, A. Pertegas, D. Tordera, H. J. Bolink, S. H. Ye, X. M. Liu, S. Sun, and W. Huang, “p–n Metallophosphor based on cationic iridium(III) complex for solid-state light-emitting electrochemical cells,” J. Mater. Chem. 21(36), 13999–14007 (2011).
[Crossref]

Ying, L.

L. Ying, C. L. Ho, H. Wu, Y. Cao, and W. Y. Wong, “White polymer light-emitting devices for solid-state lighting: materials, devices, and recent progress,” Adv. Mater. 26(16), 2459–2473 (2014).
[Crossref] [PubMed]

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Y. You, S. Lee, T. Kim, K. Ohkubo, W. S. Chae, S. Fukuzumi, G. J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Y. You, S. Lee, T. Kim, K. Ohkubo, W.-S. Chae, S. Fukuzumi, G.-J. Jhon, W. Nam, and S. J. Lippard, “Phosphorescent sensor for biological mobile zinc,” J. Am. Chem. Soc. 133(45), 18328–18342 (2011).
[Crossref] [PubMed]

Y. You and S. Y. Park, “Inter-ligand energy transfer and related emission change in the cyclometalated heteroleptic iridium complex: facile and efficient color tuning over the whole visible range by the ancillary ligand structure,” J. Am. Chem. Soc. 127(36), 12438–12439 (2005).
[Crossref] [PubMed]

Yu, Q.

P. Tao, W. L. Li, J. Zhang, S. Guo, Q. Zhao, H. Wang, B. Wei, S. J. Liu, X. H. Zhou, Q. Yu, B. S. Xu, and W. Huang, “Facile synthesis of highly efficient lepidine-based phosphorescent iridium(III) complexes for yellow and white organic light-emitting diodes,” Adv. Funct. Mater. 26(6), 881–894 (2016).
[Crossref]

Zeng, Y.

Y. Ma, H. Liang, Y. Zeng, H. R. Yang, C. L. Ho, W. J. Xu, Q. Zhao, W. Huang, and W. Y. Wong, “Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations,” Chem. Sci. (Camb.) 7(5), 3338–3346 (2016).
[Crossref]

Zhang, J.

P. Tao, W. L. Li, J. Zhang, S. Guo, Q. Zhao, H. Wang, B. Wei, S. J. Liu, X. H. Zhou, Q. Yu, B. S. Xu, and W. Huang, “Facile synthesis of highly efficient lepidine-based phosphorescent iridium(III) complexes for yellow and white organic light-emitting diodes,” Adv. Funct. Mater. 26(6), 881–894 (2016).
[Crossref]

S. Liu, J. Zhang, D. Shen, H. Liang, X. Liu, Q. Zhao, and W. Huang, “Reaction-based phosphorescent nanosensor for ratiometric and time-resolved luminescence imaging of fluoride in live cells,” Chem. Commun. (Camb.) 51(64), 12839–12842 (2015).
[Crossref] [PubMed]

K. Y. Zhang, J. Zhang, Y. Liu, S. Liu, P. Zhang, Q. Zhao, Y. Tang, and W. Huang, “Core–shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy,” Chem. Sci. (Camb.) 6(1), 301–307 (2015).
[Crossref]

Zhang, K. Y.

S. Liu, H. Liang, K. Y. Zhang, Q. Zhao, X. Zhou, W. Xu, and W. Huang, “A multifunctional phosphorescent iridium(III) complex for specific nucleus staining and hypoxia monitoring,” Chem. Commun. (Camb.) 51(37), 7943–7946 (2015).
[Crossref] [PubMed]

Q. Zhao, X. B. Zhou, T. Y. Cao, K. Y. Zhang, L. J. Yang, S. J. Liu, H. Liang, H. R. Yang, F. Y. Li, and W. Huang, “Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging,” Chem. Sci. (Camb.) 6(3), 1825–1831 (2015).
[Crossref]

K. Y. Zhang, J. Zhang, Y. Liu, S. Liu, P. Zhang, Q. Zhao, Y. Tang, and W. Huang, “Core–shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy,” Chem. Sci. (Camb.) 6(1), 301–307 (2015).
[Crossref]

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
[Crossref] [PubMed]

S. Guo, T. Huang, S. Liu, K. Y. Zhang, H. Yang, J. Han, Q. Zhao, and W. Huang, “Luminescent ion pairs with tunable emission colors for light-emitting devices and electrochromic switches,” Chem. Sci. (Camb.) (2016), doi:.
[Crossref]

Zhang, P.

K. Y. Zhang, J. Zhang, Y. Liu, S. Liu, P. Zhang, Q. Zhao, Y. Tang, and W. Huang, “Core–shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy,” Chem. Sci. (Camb.) 6(1), 301–307 (2015).
[Crossref]

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Y. Ma, H. Liang, Y. Zeng, H. R. Yang, C. L. Ho, W. J. Xu, Q. Zhao, W. Huang, and W. Y. Wong, “Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations,” Chem. Sci. (Camb.) 7(5), 3338–3346 (2016).
[Crossref]

P. Tao, W. L. Li, J. Zhang, S. Guo, Q. Zhao, H. Wang, B. Wei, S. J. Liu, X. H. Zhou, Q. Yu, B. S. Xu, and W. Huang, “Facile synthesis of highly efficient lepidine-based phosphorescent iridium(III) complexes for yellow and white organic light-emitting diodes,” Adv. Funct. Mater. 26(6), 881–894 (2016).
[Crossref]

K. Y. Zhang, J. Zhang, Y. Liu, S. Liu, P. Zhang, Q. Zhao, Y. Tang, and W. Huang, “Core–shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy,” Chem. Sci. (Camb.) 6(1), 301–307 (2015).
[Crossref]

S. Liu, H. Liang, K. Y. Zhang, Q. Zhao, X. Zhou, W. Xu, and W. Huang, “A multifunctional phosphorescent iridium(III) complex for specific nucleus staining and hypoxia monitoring,” Chem. Commun. (Camb.) 51(37), 7943–7946 (2015).
[Crossref] [PubMed]

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[Crossref] [PubMed]

Q. Zhao, X. B. Zhou, T. Y. Cao, K. Y. Zhang, L. J. Yang, S. J. Liu, H. Liang, H. R. Yang, F. Y. Li, and W. Huang, “Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging,” Chem. Sci. (Camb.) 6(3), 1825–1831 (2015).
[Crossref]

W. Xu, X. Zhao, W. Lv, H. Yang, S. Liu, H. Liang, Z. Tu, H. Xu, W. Qiao, Q. Zhao, and W. Huang, “Rational design of phosphorescent chemodosimeter for reaction-based one- and two-photon and time-resolved luminescent imaging of biothiols in living cells,” Adv. Healthc. Mater. 3(5), 658–669 (2014).
[Crossref] [PubMed]

H. Sun, S. Liu, W. Lin, K. Y. Zhang, W. Lv, X. Huang, F. Huo, H. Yang, G. Jenkins, Q. Zhao, and W. Huang, “Smart responsive phosphorescent materials for data recording and security protection,” Nat. Commun. 5, 3601 (2014).
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[Crossref]

Y. Ma, S. J. Liu, H. R. Yang, Y. Q. Wu, C. J. Yang, X. M. Liu, Q. Zhao, H. Z. Wu, J. C. Liang, F. Y. Li, and W. Huang, “Water-soluble phosphorescent iridium(III) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells,” J. Mater. Chem. 21(47), 18974–18982 (2011).
[Crossref]

Q. Zhao, F. Li, and C. Huang, “Phosphorescent chemosensors based on heavy-metal complexes,” Chem. Soc. Rev. 39(8), 3007–3030 (2010).
[Crossref] [PubMed]

S. Guo, T. Huang, S. Liu, K. Y. Zhang, H. Yang, J. Han, Q. Zhao, and W. Huang, “Luminescent ion pairs with tunable emission colors for light-emitting devices and electrochromic switches,” Chem. Sci. (Camb.) (2016), doi:.
[Crossref]

Zhao, X.

W. Xu, X. Zhao, W. Lv, H. Yang, S. Liu, H. Liang, Z. Tu, H. Xu, W. Qiao, Q. Zhao, and W. Huang, “Rational design of phosphorescent chemodosimeter for reaction-based one- and two-photon and time-resolved luminescent imaging of biothiols in living cells,” Adv. Healthc. Mater. 3(5), 658–669 (2014).
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K. Y. Zhang, J. Zhang, Y. Liu, S. Liu, P. Zhang, Q. Zhao, Y. Tang, and W. Huang, “Core–shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy,” Chem. Sci. (Camb.) 6(1), 301–307 (2015).
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Y. Ma, H. Liang, Y. Zeng, H. R. Yang, C. L. Ho, W. J. Xu, Q. Zhao, W. Huang, and W. Y. Wong, “Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations,” Chem. Sci. (Camb.) 7(5), 3338–3346 (2016).
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S. Guo, T. Huang, S. Liu, K. Y. Zhang, H. Yang, J. Han, Q. Zhao, and W. Huang, “Luminescent ion pairs with tunable emission colors for light-emitting devices and electrochromic switches,” Chem. Sci. (Camb.) (2016), doi:.
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Figures (6)

Fig. 1
Fig. 1 (a) Classification of phosphorescent iridium(III) complexes. (b) Design strategy of phosphorescent ion-paired iridium(III) complexes for ratiometric biodetection.
Fig. 2
Fig. 2 (a) Chemical structure and sensing mechanism of C1. Changes in UV-vis absorption (b) and phosphorescence spectra (c) of C1 in CH3CN/H2O (3:2, v/v) with various amounts of Cys. Inset in (c): Emission image of C1 in the absence (left) and presence (right) of Cys.
Fig. 3
Fig. 3 Calculated orbital distributions of C1 and C1-Cys.
Fig. 4
Fig. 4 Luminescence images of C1 in Hela cells before (a) and after (b) treatment of NEM. (c) Photoluminescence lifetime image of C1 in Hela cells. (d-f) Time-gated luminescence images of C1 in Hela cells with different delayed time.
Fig. 5
Fig. 5 (a) Chemical structure and sensing mechanism of ion-paired complex A1C1. (b) Changes in phosphorescence emission spectra of A1C1 in CH3CN/H2O (3:2, v/v) with various amounts of Cys. Inset in (b): Emission image of A1C1 in the absence (left) and presence (right) of Cys. (c) Titration curve plotted with phosphorescence emission intensity at 560 nm over that at 485 nm as a function of Cys equivalent.
Fig. 6
Fig. 6 Luminescence images of Hela cells incubated with A1C1 before and after treatment of NEM observed at emission channels of (a,e) 450–520 nm and (b,f) 530–630 nm (λex = 405 nm). (c,g) Ratio of emission intensity at 530–630 nm to that at 450–520 nm. (d,h) Photoluminescence lifetime images (λex = 405 nm).

Tables (1)

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Table 1 Calculated singlet and triplet states of C1 and C1-Cys.

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